Linda Hammerich
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View article: Dynamic changes in macrophage populations and resulting alterations in Prostaglandin E2 sensitivity in mice with diet-induced MASH
Dynamic changes in macrophage populations and resulting alterations in Prostaglandin E2 sensitivity in mice with diet-induced MASH Open
View article: Pro-inflammatory secretome from intestinal epithelium recruits regulatory T cells for barrier defence
Pro-inflammatory secretome from intestinal epithelium recruits regulatory T cells for barrier defence Open
Resolution of inflammation, including of colitis, requires carefully coordinated communication between different tissues. While the role of immune cells in colitis is well established, less is known about epithelial communication to its mi…
View article: What must not be named
What must not be named Open
Scientists working with animals must maintain a delicate balance between conducting high-quality science and legal and ethical responsibilities. It is time to openly discuss their workload and emotional burden to improve both animal welfar…
View article: Slamming hepatocellular carcinoma: targeting immunosuppressive macrophages via SLAMF7 reprograms the tumor microenvironment
Slamming hepatocellular carcinoma: targeting immunosuppressive macrophages via SLAMF7 reprograms the tumor microenvironment Open
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and one of the leading causes of cancer-related deaths worldwide due to limited treatment options. The tumor microenvironment (TME), which is usually immunosupp…
View article: Ferroptosis in health and disease
Ferroptosis in health and disease Open
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contain…
View article: CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization
CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization Open
Introduction The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigatio…
View article: Overcoming Resistance to Immune Checkpoint Blockade in Liver Cancer with Combination Therapy: Stronger Together?
Overcoming Resistance to Immune Checkpoint Blockade in Liver Cancer with Combination Therapy: Stronger Together? Open
Primary liver cancer, represented mainly by hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA), is one of the most common and deadliest tumors worldwide. While surgical resection or liver transplantation are the best …
View article: Fluorochrome‐dependent specific changes in spectral profiles using different compensation beads or primary cells in full spectrum cytometry
Fluorochrome‐dependent specific changes in spectral profiles using different compensation beads or primary cells in full spectrum cytometry Open
Full spectrum flow cytometry is a powerful tool for immune monitoring on a single‐cell level and with currently available machines, panels of 40 or more markers per sample are possible. However, with an increased panel size, spectral unmix…
View article: The suppressive tumor microenvironment of AFP-positive hepatocellular carcinoma and its therapeutic implications
The suppressive tumor microenvironment of AFP-positive hepatocellular carcinoma and its therapeutic implications Open
View article: Issue Information
Issue Information Open
View article: Fluorochrome-dependent specific changes in spectral profiles using different compensation beads or human cells in full spectrum cytometry
Fluorochrome-dependent specific changes in spectral profiles using different compensation beads or human cells in full spectrum cytometry Open
Full spectrum flow cytometry is a powerful tool for immune monitoring on a single-cell level and with currently available machines, panels of 40 or more markers per sample are possible. However, with an increased panel size, spectral unmix…
View article: Resolving 31 colors on a standard 3‐laser full spectrum flow cytometer for immune monitoring of human blood samples
Resolving 31 colors on a standard 3‐laser full spectrum flow cytometer for immune monitoring of human blood samples Open
Immune monitoring of patients on a single‐cell level is becoming increasingly important in various diseases. Due to the often very limited availability of human specimens and our increased understanding of the immune systems there is an in…
View article: Data from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Data from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates antitumor efficacy. In contrast to canonical T-cell receptor–induced activation, homeostatic activation yields a distinct phenotype and memory st…
View article: Figure S3 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S3 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Immunotransplant requires double checkpoint blockade
View article: Figure S3 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S3 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Immunotransplant requires double checkpoint blockade
View article: Figure S4 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S4 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Immunotransplant modulates serum cytokines levels
View article: Figure S5 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S5 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Homeostatic activation and inhibition require JAK3-signaling
View article: Data from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Data from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates antitumor efficacy. In contrast to canonical T-cell receptor–induced activation, homeostatic activation yields a distinct phenotype and memory st…
View article: Figure S4 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S4 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Immunotransplant modulates serum cytokines levels
View article: Figure S5 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S5 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Homeostatic activation and inhibition require JAK3-signaling
View article: Figure S2 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S2 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Transfer induces homeostatic inhibition
View article: Figure S1 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S1 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Transfer does not induce homeostatic inhibition on CD4+ T-cells
View article: Figure S1 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S1 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Transfer does not induce homeostatic inhibition on CD4+ T-cells
View article: Figure S2 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade
Figure S2 from Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade Open
Transfer induces homeostatic inhibition
View article: Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease
Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease Open
View article: Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer
Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer Open
Background. Surgical tumor resection is the only potentially curative treatment option for patients with biliary tract cancer (BTC). However, 5-year survival rates are still below 50% mainly due to tumor recurrence. The preoperative identi…
View article: Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity
Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity Open
View article: Inflammatory Cytokines Associated with Diagnosis, Tumor Grade and Prognosis in Patients with Neuroendocrine Tumors
Inflammatory Cytokines Associated with Diagnosis, Tumor Grade and Prognosis in Patients with Neuroendocrine Tumors Open
Background and aims: Inflammatory cytokines represent diagnostic and prognostic biomarkers in manifold cancers. Recent data suggest a pivotal role of these cytokines in different biological processes involved in the development of neuroend…
View article: Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF
Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF Open
View article: Ferroptosis in Cancer Immunotherapy—Implications for Hepatocellular Carcinoma
Ferroptosis in Cancer Immunotherapy—Implications for Hepatocellular Carcinoma Open
Ferroptosis is a recently recognized iron-dependent form of non-apoptotic regulated cell death (RCD) characterized by lipid peroxide accumulation to lethal levels. Cancer cells, which show an increased iron dependency to enable rapid growt…