Linda R. Taggart
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View article: Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial
Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial Open
View article: Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial Open
Background Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease antimicrobial resistance. We compared gut microbiome disruption and ARG carriag…
View article: Longitudinal Analysis of Mpox Virus DNA Detectability From Multiple Specimen Types During Acute Illness: A Cohort Study
Longitudinal Analysis of Mpox Virus DNA Detectability From Multiple Specimen Types During Acute Illness: A Cohort Study Open
Background Longitudinal data on the detectability of monkeypox virus (MPXV) genetic material in different specimen types are scarce. Methods We describe MPXV-specific polymerase chain reaction (PCR) results from adults with confirmed mpox …
View article: Impact of extended-infusion piperacillin-tazobactam in a Canadian community hospital
Impact of extended-infusion piperacillin-tazobactam in a Canadian community hospital Open
View article: Detection of SARS-CoV-2 from combined nasal/rectal swabs
Detection of SARS-CoV-2 from combined nasal/rectal swabs Open
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View article: Longitudinal Analysis of Mpox Virus DNA Detectability from Multiple Anatomic Compartments During Acute Illness: A Cohort Study
Longitudinal Analysis of Mpox Virus DNA Detectability from Multiple Anatomic Compartments During Acute Illness: A Cohort Study Open
View article: Trends in hospital antibiotic utilization during the coronavirus disease 2019 (COVID-19) pandemic: A multicenter interrupted time-series analysis
Trends in hospital antibiotic utilization during the coronavirus disease 2019 (COVID-19) pandemic: A multicenter interrupted time-series analysis Open
Objective: To describe the evolution of respiratory antibiotic prescribing during the coronavirus disease 2019 (COVID-19) pandemic across 3 large hospitals that maintained antimicrobial stewardship services throughout the pandemic. Design:…
View article: Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea
Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea Open
While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from Clostridioides difficile (formerly Clostridium difficile) infection (CDI) has not been well studied in large cohorts.…
View article: The development of a quality improvement project to improve infection prevention and management in patients with asplenia or hyposplenia
The development of a quality improvement project to improve infection prevention and management in patients with asplenia or hyposplenia Open
Asplenia and hyposplenia (a/hyposplenia) are associated with increased morbidity and mortality from complications including infection. The recommended measures to reduce the risks associated with infection include patient education, vaccin…
View article: 160. Could Reducing Time to Bacterial Identification From Positive Blood Cultures Improve Outcomes in Bacteremic Patients?
160. Could Reducing Time to Bacterial Identification From Positive Blood Cultures Improve Outcomes in Bacteremic Patients? Open
Background Survival of patients with septic shock is dependent on the timing of effective antibiotic administration. The initial notification by the microbiology lab of a positive blood culture is a key factor in improving patient outcomes…
View article: 2072. Do ID and Non-ID Clinicians Agree on IV to PO Switch Criteria? Results from Phase I of the INForming IV to ORal MEdication Report (INFORMER) Project
2072. Do ID and Non-ID Clinicians Agree on IV to PO Switch Criteria? Results from Phase I of the INForming IV to ORal MEdication Report (INFORMER) Project Open
Background Converting intravenous (IV) antibiotics to an oral (PO) route is an important stewardship activity to reduce patient harm, including extravasation, thrombophlebitis, and catheter-related infections. The INFORMER Project aims to …
View article: 1057. The Impact of Temporary Suspensions of an Antimicrobial Stewardship Audit and Feedback Program on Antimicrobial Utilization of General Internal Medicine Inpatients
1057. The Impact of Temporary Suspensions of an Antimicrobial Stewardship Audit and Feedback Program on Antimicrobial Utilization of General Internal Medicine Inpatients Open
Background A goal of Antimicrobial Stewardship Programs (ASP) is to optimize antimicrobial use; many using audit and feedback (AAF). Although AAF decreases unnecessary target antimicrobial use, it is resource-intensive. As a result, tempor…
View article: Antimicrobial Stewardship and Intensive Care Unit Mortality: A Systematic Review
Antimicrobial Stewardship and Intensive Care Unit Mortality: A Systematic Review Open
Our systematic review did not identify a change in mortality associated with antimicrobial stewardship using audit and feedback in the ICU setting. These results increase our confidence that audit and feedback can be safely implemented in …
View article: Risks of novel therapeutics: gonococcemia in an immune-suppressed patient receiving eculizumab
Risks of novel therapeutics: gonococcemia in an immune-suppressed patient receiving eculizumab Open
KEY POINTS A 23-year-old woman presented to a hemodialysis appointment with a one-day history of fever and rigours. Blood cultures grew Gram-negative diplococci, raising concern for Neisseria species bacteremia. The patient's previous medi…
View article: Can a smartphone app improve medical trainees’ knowledge of antibiotics?
Can a smartphone app improve medical trainees’ knowledge of antibiotics? Open
An antibiogram and treatment algorithm app increased knowledge of prescribing antimicrobials in the context of local antibiotic resistance patterns. These findings reinforce the notion that smartphone apps can be a useful and innovative me…
View article: Antimicrobial Stewardship Among Hospitalized Patients with Influenza Respiratory Tract Infections
Antimicrobial Stewardship Among Hospitalized Patients with Influenza Respiratory Tract Infections Open
Overlap between Influenza and bacterial respiratory illnesses contributes to the inappropriate use of antibiotics. One major study from the United States suggests a significant number of patients are being treated with antibiotics inapprop…
View article: Ciguatera fish poisoning after Caribbean travel
Ciguatera fish poisoning after Caribbean travel Open
A previously healthy 39-year-old Canadian-born man travelled to Havana, Cuba, for one week on business. He stayed in a local home and ate foods prepared by the family. The night before his departure home, he ate two portions of a large fis…
View article: Cumulative Antimicrobial Susceptibility Data from Intensive Care Units at One Institution: Should Data Be Combined?
Cumulative Antimicrobial Susceptibility Data from Intensive Care Units at One Institution: Should Data Be Combined? Open
Cumulative susceptibility test data (CSTD) are used to guide empirical antimicrobial therapy and to track trends in antibiotic resistance. The Clinical and Laboratory Standards Institute recommends reporting CSTD at least annually and sets…
View article: A Retrospective Review of Treatment Appropriateness and Outcomes of Enterobacteriaceae (With Inducible ampC Beta [β]-lactamase) Bacteremias at a Large Academic Medical Centre: Opportunities and Implications for Antimicrobial Stewardship
A Retrospective Review of Treatment Appropriateness and Outcomes of Enterobacteriaceae (With Inducible ampC Beta [β]-lactamase) Bacteremias at a Large Academic Medical Centre: Opportunities and Implications for Antimicrobial Stewardship Open
View article: Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study
Differential outcome of an antimicrobial stewardship audit and feedback program in two intensive care units: a controlled interrupted time series study Open
Audit and feedback antimicrobial stewardship programs can lead to significant reductions in total antimicrobial use in the ICU setting. However, this effect may be context-dependent and further work is needed to determine the ingredients n…