Lindon J. Eaves
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View article: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leverages 13 longitudinal datasets, including 3737 cognitively healthy adults (10,34…
View article: Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes
Meta-analysis of Genome wide Association Studies on Childhood ADHD Symptoms and Diagnosis Reveals 17 Novel Loci and 22 Potential Effector Genes Open
Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder for which genetic factors explain up to 75% of the variance. In this study, we performed a genome-wide association meta-analysis (GWAMA) of ADHD sym…
View article: Vaginal microbiome Lactobacillus crispatus is heritable among European American women
Vaginal microbiome Lactobacillus crispatus is heritable among European American women Open
The diversity and dominant bacterial taxa in the vagina are reported to be influenced by multiple intrinsic and extrinsic factors, including but not limited to pregnancy, contraceptive use, pathogenic states, socioeconomic status, and ance…
View article: Genetic and Environmental Influences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up
Genetic and Environmental Influences on Smoking Behavior across Adolescence and Young Adulthood in the Virginia Twin Study of Adolescent Behavioral Development and the Transitions to Substance Abuse Follow-Up Open
Little is known regarding the underlying relationship between smoking initiation and current quantity smoked during adolescence into young adulthood. It is possible that the influences of genetic and environmental factors on this relations…
View article: Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood
Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood Open
The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse, and dependence increasing across adolescence and peaking in early adulthood. Here, we leverage this temporal patterning to searc…
View article: Genes, Environments, and Developmental Research: Methods for a Multi-Site Study of Early Substance Abuse
Genes, Environments, and Developmental Research: Methods for a Multi-Site Study of Early Substance Abuse Open
The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover…
View article: Genome-wide association meta-analysis of childhood and adolescent internalising symptoms
Genome-wide association meta-analysis of childhood and adolescent internalising symptoms Open
Internalising symptoms in childhood and adolescence are as heritable as adult depression and anxiety, yet little is known of their molecular basis. This genome-wide association meta-analysis of internalising symptoms included repeated obse…
View article: A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents
A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents Open
Introduction. Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation across adolescence. Methods. Mega-analysis of pooled genetically informative dat…
View article: Birmingham and Beyond
Birmingham and Beyond Open
Nick Martin was a doctoral student of mine at the University of Birmingham in the mid 1970s. In this review, I discuss two of Nick’s earliest and most seminal contributions to the field of behavior genetics. First, Martin and Eaves’ (1977)…
View article: Cross-Cultural Comparison of Genetic and Cultural Transmission of Smoking Initiation Using an Extended Twin Kinship Model
Cross-Cultural Comparison of Genetic and Cultural Transmission of Smoking Initiation Using an Extended Twin Kinship Model Open
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic a…
View article: Extended Twin Study of Alcohol Use in Virginia and Australia
Extended Twin Study of Alcohol Use in Virginia and Australia Open
Drinking alcohol is a normal behavior in many societies, and prior studies have demonstrated it has both genetic and environmental sources of variation. Using two very large samples of twins and their first-degree relatives (Australia ≈ 20…
View article: Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts
Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts Open
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in …
View article: Attitudes to Gun Control in an American Twin Sample: Sex Differences in the Causes of Variation
Attitudes to Gun Control in an American Twin Sample: Sex Differences in the Causes of Variation Open
The genetic and social causes of individual differences in attitudes to gun control are estimated in a sample of senior male and female twin pairs in the United States. Genetic and environmental parameters were estimated by weighted least …
View article: Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals
Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals Open
Background Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert their maximum influence during different periods of development. This includes analyses of social-comm…
View article: Genotype × Environment Interaction in Psychiatric Genetics: Deep Truth or Thin Ice?
Genotype × Environment Interaction in Psychiatric Genetics: Deep Truth or Thin Ice? Open
Background: There continues to be significant investment in the detection of genotype × environment interaction (G × E) in psychiatric genetics. The implications of the method of assessment for the genetic analysis of psychiatric disorders…
View article: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 Open
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,…
View article: Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Author response: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 Open
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts.We conducted an individual-based pooled analysis of 40 twin cohorts including 143,3…
View article: A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents
A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents Open
This is the first study to find evidence of genetic factors in liability to SI at ages as young as 12. It also shows the strongest evidence to date for decay of effects of the shared environment from early adolescence to young adulthood. W…
View article: Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study
Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study Open
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.
View article: Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts
Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts Open
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis o…