Lindsay Westlake
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View article: Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets
Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets Open
Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer's underlying biology, bringing hope to inform a patient's prognosis and treatment plan. However, most approaches used in the discovery of subtypes ar…
View article: Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069”
Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069"Douglas L. OrsiDouglas L…
View article: Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists <b>BAY-4931</b> and <b>BAY-0069</b>
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists <b>BAY-4931</b> and <b>BAY-0069</b> Open
The ligand-activated nuclear receptor peroxisome-proliferator-activated receptor-γ (PPARG or PPARγ) represents a potential target for a new generation of cancer therapeutics, especially in muscle-invasive luminal bladder cancer where PPARγ…
View article: Tangent normalization for somatic copy-number inference in cancer genome analysis
Tangent normalization for somatic copy-number inference in cancer genome analysis Open
Motivation Somatic copy-number alterations (SCNAs) play an important role in cancer development. Systematic noise in sequencing and array data present a significant challenge to the inference of SCNAs for cancer genome analyses. As part of…
View article: Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. Open
VOLUME 295 (2020) PAGES 3431–3446 In response to a reviewer's request to change the x axis units of our dose-response curves from µm to m, we mistakenly changed the numbers to mm while labeling as m. The numbers in the original submission …
View article: The Tangent copy-number inference pipeline for cancer genome analyses
The Tangent copy-number inference pipeline for cancer genome analyses Open
Motivation Somatic copy-number alterations (SCNAs) play an important role in cancer development. Systematic noise in sequencing and array data present a significant challenge to the inference of SCNAs for cancer genome analyses. As part of…
View article: The chromatin accessibility landscape of primary human cancers
The chromatin accessibility landscape of primary human cancers Open
Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility…