Lindsey A. Lee
YOU?
Author Swipe
View article: Supplementary Figures 9-10 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures 9-10 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Schematic of transposon insertions in Nat10(S9) and transgene expression in livers of Fah-deficient mice after hydrodynamic injection with Nat10/shp53(S10)
View article: Supplementary Tables S7-18 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Tables S7-18 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Tables of mice(S7); CIS genes(S8); insertions(S9); human HCC CIS gene alterations(S10); steatosis-enriched CIS(S11); pathways altered in HCC(S12-18)
View article: Supplementary Figure S8 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figure S8 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary Figure S8 shows transposon insertions in CIS genes predict expression changes in human HCC
View article: Supplementary Tables S1-6 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Tables S1-6 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.
View article: Supplementary Tables S7-18 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Tables S7-18 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Tables of mice(S7); CIS genes(S8); insertions(S9); human HCC CIS gene alterations(S10); steatosis-enriched CIS(S11); pathways altered in HCC(S12-18)
View article: Supplementary Figures S1 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S1 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary Figure S1 shows FOXA1 and FOXA2 repression in steatotic mouse livers
View article: Supplementary Tables S1-6 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Tables S1-6 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.
View article: Supplementary Figures S2-4 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S2-4 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Transposon insertion profiles from animals with tumors sharing 0-2(S2), 3(S3), or >3(S4) insertions
View article: Supplementary Figures S1 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S1 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary Figure S1 shows FOXA1 and FOXA2 repression in steatotic mouse livers
View article: Supplementary Figure S8 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figure S8 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Supplementary Figure S8 shows transposon insertions in CIS genes predict expression changes in human HCC
View article: Data from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Data from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using S…
View article: Supplementary Figures S11-13 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S11-13 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
View article: Supplementary Figures S11-13 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S11-13 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
View article: Supplementary Figures S5-7 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S5-7 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Oncoprints showing steatosis-associated CIS gene amplifications, deep deletions, and mutations occurring in at least 5% of all(S5), steatosis-associated(S6), and alcohol-associated(S7) TCGA HCC cases
View article: Supplementary Figures S2-4 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S2-4 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Transposon insertion profiles from animals with tumors sharing 0-2(S2), 3(S3), or >3(S4) insertions
View article: Supplementary Figures S5-7 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures S5-7 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Oncoprints showing steatosis-associated CIS gene amplifications, deep deletions, and mutations occurring in at least 5% of all(S5), steatosis-associated(S6), and alcohol-associated(S7) TCGA HCC cases
View article: Data from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Data from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using S…
View article: Supplementary Figures 9-10 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Supplementary Figures 9-10 from <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Schematic of transposon insertions in Nat10(S9) and transgene expression in livers of Fah-deficient mice after hydrodynamic injection with Nat10/shp53(S10)
View article: Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b
Distinct effects of two hearing loss–associated mutations in the sarcomeric myosin MYH7b Open
View article: Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains Open
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations …
View article: Author response: Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Author response: Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The design of compound…
View article: Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles
Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles Open
View article: Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains Open
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations …
View article: Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart
Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart Open
Background Although the roles of alpha‐myosin heavy chain (α‐MyHC) and beta‐myosin heavy chain (β‐MyHC) proteins in cardiac contractility have long been appreciated, the biological contribution of another closely related sarcomeric myosin …
View article: Functional Differences in MYH7b That Contribute to Distinct Biological Roles across Species and in Health and Disease
Functional Differences in MYH7b That Contribute to Distinct Biological Roles across Species and in Health and Disease Open
View article: Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy
Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy Open
Background In mammals, muscle contraction is controlled by a family of 10 sarcomeric myosin motors. The expression of one of its members, MYH 7b, is regulated by alternative splicing, and while the protein is restricted to specialized musc…
View article: The ancient sarcomeric myosins found in specialized muscles
The ancient sarcomeric myosins found in specialized muscles Open
View article: <i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
<i>Sleeping Beauty</i> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors Open
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Slee…
View article: Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function
Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function Open
View article: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia
Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia Open
Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes are among the most common in human cancer and frequently occur in acute myeloid leukemia (AML). An inducible NRAS(V12)-driven AML mouse model has estab…