Lindsey J. Broadwell
YOU?
Author Swipe
View article: Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart
Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart Open
Background: Abnormalities in Ca 2+ homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca 2+ homeostasis in cardiomyocytes. Alternative splicing of a single triadin gene produces multip…
View article: Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists
Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists Open
Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an …
View article: Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart
Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart Open
Background Although the roles of alpha‐myosin heavy chain (α‐MyHC) and beta‐myosin heavy chain (β‐MyHC) proteins in cardiac contractility have long been appreciated, the biological contribution of another closely related sarcomeric myosin …
View article: Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart
Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart Open
Myosin heavy chain 7b (MYH7b) is an ancient member of the myosin heavy chain motor protein family that is expressed in striated muscles. In mammalian cardiac muscle, MYH7b RNA is expressed along with two other myosin heavy chains, β-myosin…
View article: Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain
Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain Open
Mycobacterium tuberculosis harbors over 160 genes encoding PE/PPE proteins, several of which have roles in the pathogen’s virulence. A number of PE/PPE proteins are secreted via Type VII secretion systems known as the ESX secretion systems…
View article: Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart
Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart Open
Myosin heavy chain 7b (MYH7b) is an ancient member of the myosin heavy chain motor protein family that is expressed in striated muscles. In mammalian cardiac muscle, MYH7b RNA is expressed along with two other myosin heavy chains, β-myosin…