Lindsey Shapiro
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View article: Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model
Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model Open
Voltage-gated sodium channel genes are an important family of human epilepsy genes. De novo missense mutations in SCN8A (encoding Na v 1.6) are associated with a spectrum of clinical presentation, including multiple seizure types, movement…
View article: Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease
Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease Open
Numerous SCN8A mutations have been identified, of which, the majority are de novo missense variants. Most mutations result in epileptic encephalopathy; however, some are associated with less severe phenotypes. Mouse models generated by kno…
View article: Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice Open
View article: Nanoparticle encapsulated oxytocin increases resistance to induced seizures and restores social behavior in Scn1a-derived epilepsy
Nanoparticle encapsulated oxytocin increases resistance to induced seizures and restores social behavior in Scn1a-derived epilepsy Open
View article: Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice
Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice Open
Objective The endocannabinoid system (ECS) is comprised of cannabinoid receptors 1 and 2 (CB1R and CB2R), endogenous ligands, and regulatory enzymes, and serves to regulate several important physiological functions throughout the brain and…
View article: Habits and characteristics of arboreal snakes worldwide: arboreality constrains body size but does not affect lineage diversification
Habits and characteristics of arboreal snakes worldwide: arboreality constrains body size but does not affect lineage diversification Open
Arboreal lifestyles represent common and major habitat shifts among snakes. Major habitat shifts are often facilitated by particular traits that confer advantages in the new environment. Although studies have examined the habits and charac…
View article: PD33-12 IN VIVO EVALUATION OF FUNCTIONALIZED MUSCLE SCAFFOLDS FOR RECONSTRUCTION
PD33-12 IN VIVO EVALUATION OF FUNCTIONALIZED MUSCLE SCAFFOLDS FOR RECONSTRUCTION Open
You have accessJournal of UrologyStem Cell Research: Stem Cell Research I1 Apr 2018PD33-12 IN VIVO EVALUATION OF FUNCTIONALIZED MUSCLE SCAFFOLDS FOR RECONSTRUCTION Lindsey Shapiro, Young Min Ju, John Jackson, James Yoo, Anthony Atala, and …
View article: The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice
The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice Open
A number of mutations in genes that encode ubiquitously expressed RNA-binding proteins cause tissue specific disease. Many of these diseases are neurological in nature revealing critical roles for this class of proteins in the brain. We re…