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View article: Enhancing patient stratification methods for medication review during acute admissions
Enhancing patient stratification methods for medication review during acute admissions Open
Medication review in the hospital is an effective tool for identifying inappropriate prescribing, but not every patient can receive one due to resource constraints. Thus, it is important to identify patients who stand to benefit most from …
View article: Soluble urokinase plasminogen activator receptor and interleukin‐6 improves prediction of all‐cause mortality and major adverse cardiovascular events in Type 1 diabetes
Soluble urokinase plasminogen activator receptor and interleukin‐6 improves prediction of all‐cause mortality and major adverse cardiovascular events in Type 1 diabetes Open
Background Type 1 diabetes (T1D) increases premature mortality risk, with cardiovascular disease being the leading cause. Chronic inflammation may play a role. Associations between inflammatory biomarkers and mortality are not well‐known i…
View article: Executive function and soluble urokinase-type plasminogen activator receptor (suPAR): a longitudinal study of midlife adults
Executive function and soluble urokinase-type plasminogen activator receptor (suPAR): a longitudinal study of midlife adults Open
Executive function (EF) declines with age. Declines in EF are associated with adverse outcomes, but there is substantial inter-individual variability in rate and magnitude of decline. Evidence suggests that systemic inflammation may contri…
View article: Soluble urokinase plasminogen activator receptor ( <scp>suPAR</scp> ) as a prognostic biomarker in acutely admitted patients with atrial fibrillation
Soluble urokinase plasminogen activator receptor ( <span>suPAR</span> ) as a prognostic biomarker in acutely admitted patients with atrial fibrillation Open
Background Atrial fibrillation (AF) is associated with a higher incidence of stroke, heart failure, and mortality. Risk assessment of clinical outcomes in patients hospitalized acutely with AF remains a challenge. Purpose To investigate if…
View article: Association between interleukin-6, suPAR, and hsCRP with subclinical left ventricular dysfunction in type 1 diabetes: The Thousand & 1 study
Association between interleukin-6, suPAR, and hsCRP with subclinical left ventricular dysfunction in type 1 diabetes: The Thousand & 1 study Open
Inflammatory biomarkers are independently associated with subclinical left ventricular dysfunction. Chronic inflammation may contribute to the development of myocardial dysfunction in T1D.
View article: Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial) Open
Introduction Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. Despite this, the treatment gap is wide compared with other mental health disorders. Treatment options are sparse, with only three Food …
View article: Prospective and External Validation of Machine Learning Models for Short- and Long-Term Mortality in Acutely Admitted Patients Using Blood Tests
Prospective and External Validation of Machine Learning Models for Short- and Long-Term Mortality in Acutely Admitted Patients Using Blood Tests Open
Background: Predicting mortality in emergency departments (EDs) using machine learning models presents challenges, particularly in balancing simplicity with performance. This study aims to develop models that are both simple and effective …
View article: Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases Open
Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic agent for the treatment of age-related chronic diseases. Senotherapeutics target senescen…
View article: A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge
A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge Open
Soluble urokinase plasminogen activator receptor (suPAR) is a marker of systemic chronic inflammation. Elevated suPAR levels are associated with adverse clinical outcomes, but a small subset of patients with low suPAR also experience poor …
View article: Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests.
Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests. Open
The application of machine learning (ML) models in emergency departments (EDs) to predict short- and long-term mortality encounters challenges, particularly in balancing simplicity with performance. This study addresses this gap by develop…
View article: 1ISG-002 PHARMACIST RISK STRATIFICATION: a characterisation of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge
1ISG-002 PHARMACIST RISK STRATIFICATION: a characterisation of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge Open
Background and Importance Soluble urokinase plasminogen activator receptor (suPAR) is a marker of systemic chronic inflammation thought to reflect overall disease burden. suPAR has been suggested as a prognostic marker in clinical settings…
View article: Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests
Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests Open
View article: SuPAR, biomarkers of inflammation, and severe outcomes in patients hospitalized for COVID‐19: The International Study of Inflammation in COVID‐19
SuPAR, biomarkers of inflammation, and severe outcomes in patients hospitalized for COVID‐19: The International Study of Inflammation in COVID‐19 Open
Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome. The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown. We conducted a prospective multicenter observational study of adult patien…
View article: Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood Open
View article: Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort
Socioenvironmental Adversity and Adolescent Psychotic Experiences: Exploring Potential Mechanisms in a UK Longitudinal Cohort Open
Background and Hypothesis Children exposed to socioenvironmental adversities (eg, urbanicity, pollution, neighborhood deprivation, crime, and family disadvantage) are more likely to subsequently develop subclinical psychotic experiences du…
View article: Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels
Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels Open
View article: Self-rated health and chronic inflammation are related and independently associated with hospitalization and long-term mortality in the general population
Self-rated health and chronic inflammation are related and independently associated with hospitalization and long-term mortality in the general population Open
The subjective indicator of health self-rated health (SRH) and the chronic inflammation biomarker soluble urokinase plasminogen activator receptor (suPAR) are both robust predictors of healthcare use and mortality. However, the possible re…
View article: Childhood Adversity and Midlife Health: Shining a Light on the Black Box of Psychosocial Mechanisms
Childhood Adversity and Midlife Health: Shining a Light on the Black Box of Psychosocial Mechanisms Open
View article: Improving risk indexes for Alzheimer’s disease and related dementias for use in midlife
Improving risk indexes for Alzheimer’s disease and related dementias for use in midlife Open
Knowledge of a person’s risk for Alzheimer’s disease and related dementias (ADRDs) is required to triage candidates for preventive interventions, surveillance, and treatment trials. ADRD risk indexes exist for this purpose, but each includ…
View article: Systematic Review and Meta-Analysis of the Effect of Adverse Childhood Experiences (ACEs) on Brain-Derived Neurotrophic Factor (BDNF) Levels
Systematic Review and Meta-Analysis of the Effect of Adverse Childhood Experiences (ACEs) on Brain-Derived Neurotrophic Factor (BDNF) Levels Open
There is continued interest in identifying dysregulated biomarkers that mediate associations between adverse childhood experiences (ACEs) and negative long-term health outcomes. However, little is known regarding how ACE exposure modulates…
View article: Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID‐19
Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID‐19 Open
Background Venous thromboembolism (VTE) contributes significantly to COVID‐19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels of soluble urokinase plasminogen activator receptor (…
View article: Soluble urokinase plasminogen activator receptor and decline in kidney function among patients without kidney disease
Soluble urokinase plasminogen activator receptor and decline in kidney function among patients without kidney disease Open
Background Hospitalized patients are at an increased risk of developing kidney disease after discharge, often despite the absence of any clinical indicators during hospitalization. Soluble urokinase plasminogen activator receptor (suPAR) i…
View article: Longitudinal associations between adolescents’ individualised risk for depression and inflammation in a UK cohort study
Longitudinal associations between adolescents’ individualised risk for depression and inflammation in a UK cohort study Open
Inflammation is associated with poor physical and mental health including major depressive disorder (MDD). Moreover, there is evidence that childhood adversity - a risk factor for MDD - becomes biologically embedded via elevated inflammati…
View article: Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation Open
Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases. But currently, there are no recognized standard bio…
View article: Risk of Malnutrition upon Admission and after Discharge in Acutely Admitted Older Medical Patients: A Prospective Observational Study
Risk of Malnutrition upon Admission and after Discharge in Acutely Admitted Older Medical Patients: A Prospective Observational Study Open
There is a lack of knowledge about malnutrition and risk of malnutrition upon admission and after discharge in older medical patients. This study aimed to describe prevalence, risk factors, and screening tools for malnutrition in older med…
View article: Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: A longitudinal cohort study
Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: A longitudinal cohort study Open
Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammat…
View article: The effect of the employment of experienced physicians in the Emergency Department on quality of care and equality—a quasi-experimental retrospective cohort study
The effect of the employment of experienced physicians in the Emergency Department on quality of care and equality—a quasi-experimental retrospective cohort study Open
Background Increasing acute admissions in Emergency Departments (EDs) negatively affect quality of care, safety and flow. Thus, the Danish Health Authorities recommend the presence of experienced physicians in the ED. In 2016, consultant-l…
View article: Using soluble urokinase plasminogen activator receptor to stratify patients for medication review in the emergency department
Using soluble urokinase plasminogen activator receptor to stratify patients for medication review in the emergency department Open
Aims To investigate whether the association between levels of medication use (including polypharmacy and potentially inappropriate medications [PIMs]) and health outcomes such as readmission and mortality is dependent on baseline soluble u…
View article: Linking stressful life events and chronic inflammation using suPAR (soluble urokinase plasminogen activator receptor)
Linking stressful life events and chronic inflammation using suPAR (soluble urokinase plasminogen activator receptor) Open
View article: Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor Open