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View article: Peptide-grafted nanogels for sustained endothelin and bradykinin blockade in osteoarthritis
Peptide-grafted nanogels for sustained endothelin and bradykinin blockade in osteoarthritis Open
Osteoarthritis (OA) is a widespread cause of physical disability and chronic pain, yet it lacks a pharmacological cure due to the difficulty of delivering drugs to avascular cartilage. We recently developed peptide-grafted nanogels for int…
View article: Growth differentiation factor 5 improves meniscal healing in a pilot study on rats
Growth differentiation factor 5 improves meniscal healing in a pilot study on rats Open
Purpose Meniscus injuries are common, but failed repairs remain an issue. The aim of this study was to demonstrate, in an in vivo rat model, the ability of growth differentiation factor 5 (GDF5) to improve meniscal tear healing. Methods Ei…
View article: Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route
Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route Open
View article: Endothelin and Bradykinin Long-Term Antagonisms by Peptide-Grafted Nanogels for the Treatment of Osteoarthritis: A Proof-of-Concept Study
Endothelin and Bradykinin Long-Term Antagonisms by Peptide-Grafted Nanogels for the Treatment of Osteoarthritis: A Proof-of-Concept Study Open
View article: Bioinspired Bottlebrush Polymers Effectively Alleviate Frictional Damage Both In Vitro and In Vivo
Bioinspired Bottlebrush Polymers Effectively Alleviate Frictional Damage Both In Vitro and In Vivo Open
Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, ce…
View article: In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration
In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration Open
View article: NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes
NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes Open
View article: Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer’s Disease Treatment
Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer’s Disease Treatment Open
Background and Purpose: The activation of 5-HT4 receptors with agonists has emerged as a valuable therapeutic strategy to treat Alzheimer’s disease (AD) by enhancing the nonamyloidogenic pathway. Here, the potential therapeutic effects of …
View article: Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL‐1
Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL‐1 Open
Drimane sesquiterpenoid dialdehydes are natural compounds with antiproliferative properties. Nevertheless, their mode of action has not yet been discovered. Herein, we demonstrate that various drimanes are potent inhibitors of MCL‐1 and BC…
View article: Design of Non-Haemolytic Nanoemulsions for Intravenous Administration of Hydrophobic APIs
Design of Non-Haemolytic Nanoemulsions for Intravenous Administration of Hydrophobic APIs Open
Among advanced formulation strategies, nanoemulsions are considered useful drug-delivery systems allowing to improve the solubility and the bioavailability of lipophilic drugs. To select safe excipients for nanoemulsion formulation and to …
View article: 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi Open