Explanipedia

Multi-omics reveals gut microbiota-mediated environmental adaptation in Mallards and domesticated Shaoxing ducks Open

Zhang Chun-yuan, Xuge Wang, Linfang Wang, Pan Li, Bao Ying , et al. · 2025

Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation Open

Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-Ting Tsai, Yi-Hsuan Cheng , et al. · 2025

Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating SNCA/α-syn (synuclein alpha) inclusions, remains el…

New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia Open

Linfang Wang, Shuanglong Yi, Shiping Zhang, Yu-Ting Tsai, Yi-Hsuan Cheng , et al. · 2025

We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present evidence here that lack of glial …

dAux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to α-synuclein degradation Open

Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-ting Tsai, Honglei Wang , et al. · 2023

Glia serve as double-edged swords to modulate neuropathology in Parkinson’s disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating α-synuclein (α-syn) inclus…

A new regulator of autophagy initiation in glia Open

Linfang Wang, Shiping Zhang, Shuanglong Yi, Margaret S. Ho · 2023

Macroautophagy/autophagy is the major degradation pathway in neurons for eliminating damaged proteins and organelles in Parkinson disease (PD). Like neurons, glial cells are important contributors to PD, yet how autophagy is executed in gl…

Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Cheng Jin, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Cheng Jin, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease Open

Shuanglong Yi, Linfang Wang, Margaret T. Ho, Shiping Zhang · 2023

JOURNAL/nrgr/04.03/01300535-202405000-00047/inline-graphic1/v/2023-09-28T063346Z/r/image-tiff Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits, dopaminergic neuron loss, and brain accumulation …

Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans Open

Cheng Jin, Zhipeng Wang, Pengyu Li, Jielin Tang, Tao Jiao , et al. · 2023

The intricate interaction between spermatogonial stem cell (SSC) and testicular niche is essential for maintaining SSC homeostasis; however, this interaction remains largely uncharacterized. In this study, to characterize the underlying si…

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia Open

Shiping Zhang, Shuanglong Yi, Linfang Wang, Shuhua Li, Honglei Wang , et al. · 2023

Autophagy is a major means for the elimination of protein inclusions in neurons in neurodegenerative diseases such as Parkinson’s disease (PD). Yet, the mechanism of autophagy in the other brain cell type, glia, is less well characterized …

Reviewer #2 (Public Review): Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Jin Cheng, Pengyu Li, Yiran Li, Tang Jielin , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

Author Response: Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Cheng Jin, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Jin Cheng, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

Reviewer #1 (Public Review): Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Jin Cheng, Pengyu Li, Yiran Li, Tang Jielin , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

FOXC2 marks and maintains the primitive spermatogonial stem cells subpopulation in the adult testis Open

Zhipeng Wang, Cheng Jin, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

In adult mammals, spermatogenesis embodies the complex transition from spermatogonial stem cells (SSCs) to spermatozoa. This process is initiated by the dynamic transition among a series of SSCs subpopulations. However, it remains elusive …

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Cheng Jin, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2023

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

Identification of quiescent FOXC2 + spermatogonial stem cells in adult mammals Open

Zhipeng Wang, Jin Cheng, Pengyu Li, Yiran Li, Jielin Tang , et al. · 2022

In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations. Their individual identities a…

Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective Open

Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S. Ho, Shiping Zhang · 2022

Parkinson’s disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such as anosmia, depress…

A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival Open

Linfang Wang, Honglei Wang, Margaret S. Ho · 2021

Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common cause of familial and sporadic Parkinson’s disease (PD). A plethora of evidence has indicated a role for LRRK2 in endolysosomal trafficking in neurons, while LRRK2 fun…

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia Open

Shiping Zhang, Shuanglong Yi, Linfang Wang, Shuhua Li, Honglei Wang , et al. · 2021

Autophagy is a major means for the elimination of protein inclusions in neurons in neurodegenerative diseases such as Parkinson’s disease (PD). Yet, the mechanism of autophagy in the other brain cell type, glia, is less well characterized …

VAMP7-dependent mitochondria-lysosome contacts contribute to glial mitochondrial dynamics and dopaminergic neuron survival Open

Honglei Wang, Linfang Wang, Shuanglong Yi, Shiping Zhang, Margaret S. Ho · 2021

Summary Disrupted mitochondrial dynamics in neurons are linked to neurodegenerative diseases, but their regulation in glia remains poorly understood. Here, we show that the R-SNARE protein VAMP7 regulates the untethering of mitochondria–ly…

Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body Open

Mengying Yang, Honglei Wang, Changyan Chen, Shiping Zhang, Mengxiao Wang , et al. · 2021

Significance Brain function relies on tasks executed by different types of neurons generated via diverse mechanisms. Combining a series of genetic, cellular, and behavioral approaches, we identify a two-step glia-to-neuron signal that regu…

Distinctive Alteration of Neuropeptide Y Expression Responsible for Neuro-Proliferation Following Zebrafish Spinal Cord Injury Open

Chun Cui, Linfang Wang, Shu-Bing Huang, Peng Zhao, Yong Q. Chen , et al. · 2021

In strong contrast to the limited repair within the mammalian central nervous system, the spinal cord of adult zebrafish is capable of regeneration following injury. Understanding the mechanism underlying neural regeneration and functional…

Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression‐Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress Open

Yiqiang Hu, Ranyang Tao, Linfang Wang, Lang Chen, Ze Lin , et al. · 2021

Oxidative stress is relevant in compression‐induced nucleus pulposus (NP) cell apoptosis and intervertebral disc (IVD) degeneration. Exosomes derived from bone mesenchymal stem cells (BMSCs‐Exos) are key secretory products of MSCs, with im…

The phosphorylation of the Smad2/3 linker region by nemo-like kinase regulates TGF-β signaling Open

Junbo Liang, Yanchi Zhou, Ning Zhang, Dingding Wang, Xiao‐Wen Cheng , et al. · 2021

Panoramic transcriptome analysis and functional screening of long noncoding RNAs in mouse spermatogenesis Open

Kai Li, Jiayue Xu, Yanyun Luo, Dingfeng Zou, Ruiqin Han , et al. · 2020

Long noncoding RNAs (lncRNAs) have emerged as diverse functional regulators involved in mammalian development; however, large-scale functional investigation of lncRNAs in mammalian spermatogenesis in vivo is lacking. Here, we delineated th…

Effects of Urbanization on Water Quality and the Macrobenthos Community Structure in the Fenhe River, Shanxi Province, China Open

Linfang Wang, Hua Li, Jinhua Dang, Ying Zhao, Zhu Yuen , et al. · 2020

The relationships between land use types, water and sediment parameters, and macrobenthos community structures in the upper and middle reaches of the Fenhe River and urbanization intensity were studied. Samples were collected from 23 sampl…

Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansion In Vitro Open

Ou Jinhuan, Yiran Li, Zhipeng Wang, Jin Cheng, Kai Li , et al. · 2020

Objective To discover critical genes contributing to the stemness and maintenance of spermatogonial stem cells (SSCs) and provide new insights into the function of the leucine-rich repeat (LRR) family member Lrrc34 (leucine-rich repeat-con…

A long noncoding RNA binding to QKI-5 regulates germ cell apoptosis via p38 MAPK signaling pathway Open

Kai Li, Shunshun Zhong, Yanyun Luo, Dingfeng Zou, Mengzhen Li , et al. · 2019

Pyocyanin induces NK92 cell apoptosis via mitochondrial damage and elevated intracellular Ca2+ Open

Ting Li, Xiaoyuan Huang, Zhechen Yuan, Linfang Wang, Miaobo Chen , et al. · 2018

Pseudomonas aeruginosa-derived pigment pyocyanin (PCN) has been proved to induce cell apoptosis mediated by the generation of reactive oxygen species (ROS), which has been studied mainly in epithelial cells and neutrophils. However, we pre…

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