Explanipedia

Histone acetylation homeodynamics navigates cell survival and apoptosis Open

Kang Li, Ling Tian, Wenxin Cao, Jiahui Zhang, Wenhao Zhang , et al. · 2025

The balance between inhibitor of apoptosis proteins (IAPs) and pro-apoptotic proteins (PAPs) tightly and precisely regulates cellular homeostasis. However, the epigenetic mechanism by which this balance is maintained in vivo remains largel…

Advances in Quantitative Techniques for Mapping RNA Modifications Open

Ling Tian, Bharathi Vallabhaneni, Yie‐Hwa Chang · 2025

RNA modifications are essential regulators of gene expression and cellular function, modulating RNA stability, splicing, translation, and localization. Dysregulation of these modifications has been linked to cancer, neurodegenerative disor…

Health literacy relates to self-regulation of eating behavior through physical activity and self-efficacy pathways Open

Yuanwei Lu, Ling Tian, Xiong Ke · 2025

The mechanisms by which health literacy (HL), a key factor in promoting individual health behaviors, including self-regulation of eating behaviors (SREB), relates to dietary self-regulation in adults remain unclear. Specifically, further r…

A Review on the Synthetic Methods for the BODIPY Core Open

Ruihan Yang, Hao Guan, Jiayan Jin, Tianran Zheng, Limin He , et al. · 2025

Boron-dipyrromethene (BODIPY) has attracted extensive research attention in recent years due to its excellent photophysical properties, good chemical stability, and structural tunability, demonstrating broad application in fields such as f…

TFAP2A induces cisplatin resistance via BNIP3-mediated mitophagy in non-small cell lung cancer Open

Lili Guo, Xiaohua Yang, Hai-Zhen Jin, Ling Tian · 2025

TFAP2A overexpresses significantly in NSCLC, and promotes cisplatin resistance through BNIP3-mediated mitophagy.

Targeted search for an individual SMBHB in NANOGrav 15-year and EPTA DR2 data sets Open

Ling Tian, Yan-Chen Bi, Yu-Mei Wu, Qing-Guo Huang · 2025

While pulsar timing array (PTA) collaborations have reported evidence for a stochastic gravitational wave background (GWB), the detection of continuous gravitational waves (GWs) from a confirmed supermassive black hole binary (SMBHB) would…

20E-induced Kr-h1 expression facilitates developmental transitions depending on chromosome accessibility of BR-C enhancers Open

Shihui Long, Yongyu Qiu, Lin Tong, Shu‐Min Huang, Wenhao Zhang , et al. · 2025

Transcription factors and histone modification-mediated chromatin accessibility coordinately regulate spatiotemporal expression of genes that control growth and development. It is well documented that juvenile hormone-activated Kr-h1 antag…

Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects Open

Ling Tian, Qien Zhong, Yonggong Yang, Wenmei Wu, Yang Xiao , et al. · 2025

Population genomics of Vitis pseudoreticulata reveals the genetic basis of fungal resistance in grapevine Open

Zhen Zhang, Wénwén Liú, Tianhao Zhang, Zhuyifu Chen, Mengyan Zhang , et al. · 2025

The genomic and epigenomic landscapes of hemizygous genes across crops with contrasting reproductive systems Open

Yanling Peng, Yiwen Wang, Yuting Liu, Xinyue Fang, Lin Cheng , et al. · 2025

Hemizygous genes, which are present on only one of the two homologous chromosomes of diploid organisms, have been mainly studied in the context of sex chromosomes and sex-linked genes. However, these genes can also occur on the autosomes o…

Combined early palliative care for non-small-cell lung cancer patients: a randomized controlled trial in Chongqing, China Open

Mengting Chen, Huiqing Yu, Liejun Yang, Yang Hong, Haoyang Cao , et al. · 2023

Purpose More effective approaches are needed to improve the prognosis of non-small-cell lung cancer (NSCLC) patients. Thus, we used the E-warm model to assess how early integration of interdisciplinary palliative care was related to the qu…

Leukocyte associated immunoglobulin-like receptor 1 modulates immune response to Staphylococcus aureus infection Open

Hannah K. Dorando, Helen E. Rich, Helen Warheit-Niemi, Evan C. Mutic, Kelly Tomaszewski , et al. · 2023

Immunity is a balance of maximal pathogen defense with minimal host damage. Inhibitory immune receptors are important for maintaining this balance. We recently identified elevated levels of leukocyte-associated immunoglobulin (Ig)-like rec…

An anoikis-related gene signature predicts prognosis and reveals immune infiltration in hepatocellular carcinoma Open

Chen Yang, Qiao-xin Lin, Yiting Xu, Fang-jing Qian, Chen-jing Lin , et al. · 2023

Background Hepatocellular carcinoma (HCC) is a global health burden with poor prognosis. Anoikis, a novel programmed cell death, has a close interaction with metastasis and progression of cancer. In this study, we aimed to construct a nove…

Cytoskeleton Protein BmACT1 Is Potential for the Autophagic Function and Nuclear Localization of BmAtg4b in Bombyx mori Open

Qiuqin Ma, Jianhao Deng, Hanbo Li, Zhijun Huang, Ling Tian · 2023

Homologs of Autophagy-related (Atg) protein 4 are reported to cleave LC3 protein and facilitate autophagy occurrence differently in mammals, whereas their functions have not been investigated in insects. Three homologs, including BmAtg4a a…

The Gut Bacterial Community of Cold-Tolerant Black Soldier Fly ( Hermetia Illucens ) Larvae Open

Chong Ma, Zhijun Huang, Xingbao Feng, Ying Cui, Xinyu Duan , et al. · 2023

Morphofunctional characterization of hemocytes in black soldier fly larvae Open

Daniele Bruno, Aurora Montali, Marzia Bruna Gariboldi, Anna Katarzyna Wrońska, Agata Kaczmarek , et al. · 2022

In insects, the cell‐mediated immune response involves an active role of hemocytes in phagocytosis, nodulation, and encapsulation. Although these processes have been well documented in multiple species belonging to different insect orders,…

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness Open

Fu-rao Liu, Mingjie Jiang, Zhu Mei, Chen-jing Lin, Ling Tian · 2022

A Novel Mcl-1 Inhibitor Synergizes with Venetoclax to Induce Apoptosis in Cancer Cells Open

Tianming Zhao, Huien Zhan, Shurong Xie, Cheng Jiang, Shengbin Lin , et al. · 2022

Background Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in treatment of hematologic malignancies. Mcl-1, another anti-…

Transcription and Post-translational Regulation of Autophagy in Insects Open

Rongsong Li, Yang Xiao, Kang Li, Ling Tian · 2022

Autophagy attracts great attention, and numerous progresses have been obtained in the last two decades. Autophagy is implicated in mammalian neurodegenerative diseases, tumorigenesis, as well as development in insects. The regulatory mecha…

Transcriptional and Post-Transcriptional Regulation of Autophagy Open

Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li , et al. · 2022

Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient depriva…

Anticancer Benefit of Metformin in Patients With Early-Stage Pancreatic Cancer: A Retrospective Cohort Study Open

Yang Chen, Fang-jing Qian, Zhiqiang Ye, Wenxia Xie, You-di He , et al. · 2022

Background: Epidemiologic studies have produced conflicting results on the effects of metformin on pancreatic cancer. This study aimed to observe and analyze whether metformin use is associated with better prognosis in pancreatic cancer. M…

Correction to: microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings Open

Chi Fang, Chenyun Dai, Zhu Mei, Mingjie Jiang, Dian-na Gu , et al. · 2021

Insights Into the Immune Response of the Black Soldier Fly Larvae to Bacteria Open

Daniele Bruno, Aurora Montali, Maristella Mastore, Maurizio Francesco Brivio, Amr A. Mohamed , et al. · 2021

In insects, a complex and effective immune system that can be rapidly activated by a plethora of stimuli has evolved. Although the main cellular and humoral mechanisms and their activation pathways are highly conserved across insects, the …

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype Open

Ling Tian, Monique Chavez, Gue Su Chang, Nichole Helton, Casey Katerndahl , et al. · 2021

Kdm6a/Utx , a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome ( Uty ) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse a…

Prognostic significance of platelet lymphocyte ratio in patients with melanoma Open

Enwen Wang, Hui Huang, Long Tang, Ling Tian, Liejun Yang , et al. · 2021

Background: The aim of this study was to systematically evaluate the prognostic role of platelet lymphocyte ratio (PLR) in patients with melanoma through performing a meta-analysis. Methods: PubMed, EMBASE, Web of Science, and China Nation…

Kdm6a Deficiency Restricted to Mouse Hematopoietic Cells Causes an Age- and Sex-dependent Myelodysplastic Syndrome-Like Phenotype Open

Ling Tian, Monique Chavez, Gue Su Chang, Nichole Helton, Casey Katerndahl , et al. · 2021

Kdm6a/Utx , a gene on the X chromosome, encodes a histone K27me3 demethylase that has an orthologue on the Y chromosome ( Uty )[1]. We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyelocytic …

P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8–PE ubiquitin-like system Open

Wenmei Wu, Kang Li, Sanyou Guo, Jing Xu, Qiuqin Ma , et al. · 2021

Protein acetylation plays potential roles in regulating autophagy occurrence. However, it varies greatly between yeast and mammals, and has not been thoroughly investigated in other organisms. Here, we reported that the components of BmAtg…

Transcriptome analysis reveals potential function of long non-coding RNAs in 20-hydroxyecdysone regulated autophagy in Bombyx mori Open

Huili Qiao, Jingya Wang, Yuanzhuo Wang, Juanjuan Yang, Bofan Wei , et al. · 2021

Background 20-hydroxyecdysone (20E) plays important roles in insect molting and metamorphosis. 20E-induced autophagy has been detected during the larval–pupal transition in different insects. In Bombyx mori , autophagy is induced by 20E in…

Global Impact of COVID-19 on Stroke Care and IV Thrombolysis Open

Raul G. Nogueira, Muhammad M. Qureshi, Mohamad Abdalkader, Sheila Cristina Ouriques Martins, Hiroshi Yamagami , et al. · 2021

The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declin…

Knockdown of SNORA47 Inhibits the Tumorigenesis of NSCLC via Mediation of PI3K/Akt Signaling Pathway Open

Huiqing Yu, Ling Tian, Liejun Yang, Shihong Liu, Sixiong Wang , et al. · 2021

Background Non-small cell lung cancer (NSCLC) is a frequently diagnosed aggressive cancer all over the world. Small nucleolar RNAs (snoRNAs) are a group of non-coding mediatory RNAs. A previous report indicated that small nucleolar RNA 47 …

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