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View article: Metal uptake systems underpin <i>Enterococcus faecalis</i> virulence in both non-diabetic and diabetic wound infection models
Metal uptake systems underpin <i>Enterococcus faecalis</i> virulence in both non-diabetic and diabetic wound infection models Open
Wound infections remain an important medical problem, which is aggravated by the prevalence of multidrug-resistant bacteria. Among them, Enterococcus faecalis is a major pathogen of surgical site incisional and diabetic chronic wounds, but…
View article: Metal Uptake Systems Underpin <i>Enterococcus faecalis</i> Virulence in Both Non-Diabetic and Diabetic Wound Infection Models
Metal Uptake Systems Underpin <i>Enterococcus faecalis</i> Virulence in Both Non-Diabetic and Diabetic Wound Infection Models Open
Wound infections remain an important medical problem, which is aggravated by the prevalence of multidrug resistant bacteria. Among them, Enterococcus faecalis is a major pathogen of surgical site incisional and of diabetic chronic wounds, …
View article: A Novel Digital PCR Assay for Accurate Detection and Differentiation of Focal and Non-Focal Subtypes of Mesenchymal–Epithelial Transition (MET) Gene Amplification in Lung Cancer
A Novel Digital PCR Assay for Accurate Detection and Differentiation of Focal and Non-Focal Subtypes of Mesenchymal–Epithelial Transition (MET) Gene Amplification in Lung Cancer Open
Background/Objectives: Mesenchymal–epithelial transition (MET) gene amplification is a critical biomarker in non-small cell lung cancer (NSCLC), significantly influencing treatment decisions and prognostic evaluations. However, current det…
View article: Role of sortase-assembled Ebp pili in <i>Enterococcus faecalis</i> adhesion to iron oxides and its impact on extracellular electron transfer
Role of sortase-assembled Ebp pili in <i>Enterococcus faecalis</i> adhesion to iron oxides and its impact on extracellular electron transfer Open
Enterococcus faecalis sortase-assembled endocarditis and biofilm-associated pili (Ebp) are virulence factors implicated in enterococcal biofilm-associated infections and gastrointestinal colonization. We previously showed that E. faecalis …
View article: Genome-wide analysis of <i>Enterococcus faecalis</i> genes that facilitate interspecies competition with <i>Lactobacillus crispatus</i>
Genome-wide analysis of <i>Enterococcus faecalis</i> genes that facilitate interspecies competition with <i>Lactobacillus crispatus</i> Open
Enterococci are opportunistic pathogens notorious for causing a variety of infections. While both Enterococcus faecalis and Lactobacillus crispatus are commensal residents of the vaginal tract, the molecular mechanisms that enable E. faeca…
View article: A Novel Digital PCR Assay for Accurate Detection and Differentiation of Focal and Non-Focal Subtypes of <i>MET</i> Amplification in Lung Cancer
A Novel Digital PCR Assay for Accurate Detection and Differentiation of Focal and Non-Focal Subtypes of <i>MET</i> Amplification in Lung Cancer Open
Mesenchymal–epithelial transition (MET) gene amplification is a critical biomarker in non-small cell lung cancer (NSCLC), significantly influencing treatment decisions and prognostic evaluations. However, current detection methods such as …
View article: Genome-wide analysis of<i>Enterococcus faecalis</i>genes that facilitate interspecies competition with<i>Lactobacillus crispatus</i>
Genome-wide analysis of<i>Enterococcus faecalis</i>genes that facilitate interspecies competition with<i>Lactobacillus crispatus</i> Open
Enterococci are opportunistic pathogens notorious for causing a variety of infections. While both Enterococcus faecalis and Lactobacillus crispatus are commensal residents of the vaginal tract, the molecular mechanisms that enable E. faeca…
View article: Trivalent immunization with metal-binding proteins confers protection against enterococci in a mouse infection model
Trivalent immunization with metal-binding proteins confers protection against enterococci in a mouse infection model Open
Enterococcus faecalis is ranked among the top five bacterial pathogens responsible for catheter-associated urinary tract infections, wound infections, secondary root canal infections, and infective endocarditis. Previously, we showed that …
View article: An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis
An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis Open
Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS) arising from exposure to the mammalian immune system and environmental stresses. Here we report the discovery of an ROS-sensing RNA-modifying enzyme th…
View article: Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence
Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence Open
Among the unfavorable conditions bacteria encounter within the host is restricted access to essential trace metals such as iron. To overcome iron deficiency, bacteria deploy multiple strategies to scavenge iron from host tissues, with abun…
View article: Identification of Multiple Iron Uptake Mechanisms in<i>Enterococcus faecalis</i>and Their Relationship to Virulence
Identification of Multiple Iron Uptake Mechanisms in<i>Enterococcus faecalis</i>and Their Relationship to Virulence Open
Among the unfavorable conditions bacteria encounter within the host is restricted access to essential trace metals such as iron. To overcome iron deficiency, bacteria deploy multiple strategies to scavenge iron from host tissues with abund…
View article: An RNA modification enzyme directly senses reactive oxygen species for translational regulation in<i>Enterococcus faecalis</i>
An RNA modification enzyme directly senses reactive oxygen species for translational regulation in<i>Enterococcus faecalis</i> Open
Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS) arising from exposure to the mammalian immune system and environmental stresses. Here we report the discovery of an ROS-sensing RNA-modifying enzyme th…
View article: Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions
Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions Open
Many infections are polymicrobial and biofilm-associated in nature. Iron is essential for many metabolic processes and plays an important role in controlling infections, where the host restricts iron as a defense mechanism against invading…
View article: The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms
Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms Open
Enterococcus faecalis is often co-isolated with Pseudomonas aeruginosa in polymicrobial biofilm-associated infections of wounds and the urinary tract. As a defense strategy, the host innately restricts iron availability at infection sites.…
View article: The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of <i>Enterococcus faecalis</i> Virulence
The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of <i>Enterococcus faecalis</i> Virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: c-di-AMP Is Essential for the Virulence of <i>Enterococcus faecalis</i>
c-di-AMP Is Essential for the Virulence of <i>Enterococcus faecalis</i> Open
Second messenger nucleotides are produced by bacteria in response to environmental stimuli and play a major role in the regulation of processes associated with bacterial fitness, including but not limited to osmoregulation, envelope homeos…
View article: c-di-AMP is essential for the virulence of <i>Enterococcus faecalis</i>
c-di-AMP is essential for the virulence of <i>Enterococcus faecalis</i> Open
Second messenger nucleotides are produced by bacteria in response to environmental stimuli and play a major role in the regulation of processes associated with bacterial fitness, including but not limited to osmoregulation, envelope homeos…
View article: The composition and function of<i>Enterococcus faecalis</i>membrane vesicles
The composition and function of<i>Enterococcus faecalis</i>membrane vesicles Open
Membrane vesicles (MVs) contribute to various biological processes in bacteria, including virulence factor delivery, host immune evasion, and cross-species communication. MVs are frequently being discharged from the surface of both Gram-ne…
View article: The composition and function of<i>Enterococcus faecalis</i>membrane vesicles
The composition and function of<i>Enterococcus faecalis</i>membrane vesicles Open
Membrane vesicles (MVs) contribute to various biological processes in bacteria, including virulence factor delivery, antimicrobial resistance, host immune evasion and cross-species communication. MVs are frequently released from the surfac…
View article: Enterococcus faecalis Manganese Exporter MntE Alleviates Manganese Toxicity and Is Required for Mouse Gastrointestinal Colonization
Enterococcus faecalis Manganese Exporter MntE Alleviates Manganese Toxicity and Is Required for Mouse Gastrointestinal Colonization Open
Bacterial pathogens encounter a variety of nutritional environments in the human host, including nutrient metal restriction and overload. Uptake of manganese (Mn) is essential for Enterococcus faecalis growth and virulence; however, it is …
View article: <i>Enterococcus faecalis</i>manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization
<i>Enterococcus faecalis</i>manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization Open
Bacterial pathogens encounter a variety of nutritional environments in the human host, including nutrient metal restriction and overload. Uptake of manganese (Mn) is essential for Enterococcus faecalis growth and virulence; however, it is …
View article: Correction for Keogh et al., “Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism”
Correction for Keogh et al., “Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism” Open
Volume 9, issue 2, e00626-17, 2018, [https://doi.org/10.1128/mBio.00626-17][1]. The following funding information and acknowledgment should have appeared in the article.
Artur Matysik was supported by the National Medical Research Council…
View article: Role of sortase-assembled Ebp pili in<i>Enterococcus faecalis</i>adhesion to iron oxides and its impact on extracellular electron transfer
Role of sortase-assembled Ebp pili in<i>Enterococcus faecalis</i>adhesion to iron oxides and its impact on extracellular electron transfer Open
Enterococcus faecalis sortase-assembled endocarditis and biofilm-associated pili (Ebp) are a virulence factor implicated in enterococcal biofilm-associated infections and gastrointestinal colonization. We previously showed that E. faecalis…
View article: Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism
Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism Open
Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated …
View article: The role of iron in Enterococcus faecalis biofilm formation
The role of iron in Enterococcus faecalis biofilm formation Open
Enterococcal biofilm-associated infections are a major challenge in hospitals due to their tolerance to host defenses and their intrinsic and acquired antimicrobial resistance. Enterococcus faecalis is a member of the gut microbiota and is…
View article: Student Adoption Of Facebook Private Groups For Mobile Learning In Hong Kong
Student Adoption Of Facebook Private Groups For Mobile Learning In Hong Kong Open
Mobile learning using Facebook is increasingly used by faculty in universities to improve student engagement. This study examines the determinants influencing students’ acceptance of Facebook for mobile learning. Seven determinants were id…
View article: Extracellular Electron Transfer Powers<i>Enterococcus faecalis</i>Biofilm Metabolism
Extracellular Electron Transfer Powers<i>Enterococcus faecalis</i>Biofilm Metabolism Open
Enterococci are important human commensals and significant opportunistic pathogens associated with endocarditis, urinary tract infections, wound and surgical site infections, and medical device associated infections. These infections often…