Ling Sum Liu
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View article: Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation Open
The development of selective ligands to target DNA G-quadruplexes (G4s) and i-motifs (iMs) has revealed their relevance in transcriptional regulation. However, most of these ligands are unable to target individual G4s or iMs in the genome,…
View article: Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages
Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages Open
We synthesized new para-dialkylaminonitrobiphenyl (ANBP) derivatives, s-ANBP and t-ANBP, functionalized with dimethyltrityl and phosphoramidite groups for incorporation into DNA backbones as photocleavable linkers via solid-phase sy…
View article: Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation Open
The development of selective ligands to target DNA G-quadruplexes (G4s) and i-motifs (iMs) has revealed their relevance in transcriptional regulation. However, most of these ligands are unable to target individual G4s or iMs in the genome,…
View article: TNA‐Mediated Antisense Strategy to Knockdown Akt Genes for Triple‐Negative Breast Cancer Therapy
TNA‐Mediated Antisense Strategy to Knockdown Akt Genes for Triple‐Negative Breast Cancer Therapy Open
Triple‐negative breast cancer (TNBC) remains a significant challenge in terms of treatment, with limited efficacy of chemotherapy due to side effects and acquired drug resistance. In this study, a threose nucleic acid (TNA)‐mediated antise…
View article: Recent progress in stimuli‐responsive DNA‐based logic gates: Design, working principles and biological applications
Recent progress in stimuli‐responsive DNA‐based logic gates: Design, working principles and biological applications Open
Stimuli‐responsive DNA‐based logic gates have emerged as a promising field at the intersection of synthetic biology and nanotechnology. These gates exploit the unique properties of DNA molecules to perform programmable computational operat…
View article: An Ultra-Stable Threose Nucleic Acid-Based Biosensors for Rapid and Sensitive Nucleic Acid Detection and in Vivo Imaging
An Ultra-Stable Threose Nucleic Acid-Based Biosensors for Rapid and Sensitive Nucleic Acid Detection and in Vivo Imaging Open
View article: Specific and Sensitive in Vitro and in Vivo Nucleic Acid Detection and Imaging Using Graphene Oxide-Based Biosensors Composed of Unnatural Synthetic Threose Nucleic Acid as Capture Probes
Specific and Sensitive in Vitro and in Vivo Nucleic Acid Detection and Imaging Using Graphene Oxide-Based Biosensors Composed of Unnatural Synthetic Threose Nucleic Acid as Capture Probes Open
View article: Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations
Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations Open
In this study, we synthesized two phosphoramidites based on 2,7-bis-{4-nitro-8-[3-(2-propyl)-styryl]}-9,9-bis-[1-(3,6-dioxaheptyl)]-fluorene (BNSF) and 4,4'-bis-{8-[4-nitro-3-(2-propyl)-styryl]}-3,3'-di-methoxybiphenyl (BNSMB) structures a…
View article: Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery
Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery Open
Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scien…
View article: Biologically stable threose nucleic acid-based probes for real-time microRNA detection and imaging in living cells
Biologically stable threose nucleic acid-based probes for real-time microRNA detection and imaging in living cells Open
View article: Facile construction of a DNA tetrahedron in unconventional ladder-like arrangements at room temperature
Facile construction of a DNA tetrahedron in unconventional ladder-like arrangements at room temperature Open
An isothermal assembly of DNA tetrahedron at room temperature in a quantitative yield.