Explanipedia

The synergy of morphokinetic parameters and sHLA-G in cleavage embryo enhancing implantation rates Open

Chunyan Jiang, Menghui Geng, Can Zhang, Hong She, Dalin Wang , et al. · 2024

Objective: This study aimed to assess the relationship between implantation and soluble HLA-G (sHLA-G) expression in cleavage embryo culture medium (ECM) in conjunction with early developmental kinetics determined by time-lapse imaging (TL…

The Biological Characteristics of Long Cell-Free DNA in Spent Embryos Culture Medium as Noninvasive Biomarker in In-Vitro Embryo Selection Open

Min Pan, Huajuan Shi, Ting Qi, Qinyu Ge, Lingbo Cai , et al. · 2024

Establishing a human embryonic stem cell line (SKLRMe005-A) from a blastocyst with congenital heart disease (CHD) Open

Chuyu Li, Xiaohan Dong, Yu-Ting Lin, Xueping Sun, Lingbo Cai , et al. · 2023

GATA binding protein 6 (GATA6) is an important transcription factor of cardiovascular endothelial cells, has the potential to regulate the process of cardiac development. Consequently, its abnormal expression is related to congenital heart…

Dynamic Expression of Cell-Free RNA in Preimplantation Embryo Basing Agarose Amplification Open

Huajuan Shi, Min Pan, Yuqi Sheng, Ting Qi, Yuqing Sun , et al. · 2023

A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst Open

Huajuan Shi, Min Pan, Erteng Jia, Wenxiang Lu, Ying Zhou , et al. · 2023

The rate of pregnancy can be affected by many factors in assisted reproductive technology (ART), and one of which is the quality of embryos. Therefore, selecting the embryos with high potential is crucial for the outcome. Fifteen spent bla…

Majority of transferred mosaic embryos developed healthy live births revealed by a preclinical study using embryonic morphology assessment and noninvasive PGT-A on cell-free DNA in blastocoel fluid Open

Lingbo Cai, Qiao Zeng, Chao Gao, Wei Wu, Jiandong Shen , et al. · 2022

Extracellular cell-free RNA profile in human large follicles and small follicles Open

Huajuan Shi, Min Pan, Yuqi Sheng, Erteng Jia, Ying Wang , et al. · 2022

Background: Previous studies have shown that a large number of valuable and functional cell-free RNAs (cfRNAs) were found in follicular fluid. However, the species and characteristics of follicular fluid cfRNAs have not been reported. Furt…

Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation Open

Wenqi Hu, Haitao Zeng, Yanan Shi, Chuanchuan Zhou, Jiana Huang , et al. · 2022

Single-Cell Quantitative Proteomic Analysis of Human Oocyte Maturation Revealed High Heterogeneity in In Vitro–Matured Oocytes Open

Yueshuai Guo, Lingbo Cai, Xiaofei Liu, Long Ma, Hao Zhang , et al. · 2022

Oocyte maturation is pertinent to the success of in vitro maturation (IVM), which is used to overcome female infertility, and produced over 5000 live births worldwide. However, the quality of human IVM oocytes has not been investigated at …

Nucleoporin37 may play a role in early embryo development in human and mice Open

Yawen Peng, Jiandong Shen, Yan Gao, Wangjuan Dai, Shuang Liang , et al. · 2022

Maternal-effect genes (MEGs) play an important role in maintaining the survival and development of mammalian embryos at the cleavage stage after fertilization. Despite long-term efforts, the MEGs that regulate preimplantation embryo develo…

Establishment of human embryonic stem cell (SKLRMe001-A)carrying Azoospermic factor c (AZFc) deletions Open

Chuyu Li, Lingbo Cai, Juan Dong, Ning Song, Jing Zhou , et al. · 2021

Sorbitol accumulation decreases oocyte quality in aged mice by altering the intracellular redox balance Open

Yuexin Zhang, Zhengjie Yan, Hanwen Liu, Lingjun Li, Chun Yuan , et al. · 2021

Sorbitol is a product of glucose metabolism through the polyol pathway. Many studies have demonstrated that excessive sorbitol can disrupt the intracellular redox balance. However, we still know very little about the impact of excessive in…

The integrity of cfDNA in follicular fluid and spent medium from embryo culture is associated with embryo grade in patients undergoing in vitro fertilization Open

Min Pan, Huajuan Shi, Zhiyu Liu, Juan Dong, Lingbo Cai , et al. · 2021

A novel mutation of <i>AMHR2</i> in two brothers with persistent Müllerian duct syndrome and their intracytoplasmic sperm injection outcome Open

Jianzheng Fang, Gao Gao, Jinyong Liu, Lingbo Cai, Yugui Cui , et al. · 2021

Background Persistent Müllerian duct syndrome (PMDS) is defined as the presence of Müllerian duct derivatives in an otherwise normally virilized 46, XY male. It is usually caused by homozygous or compound heterozygous mutations in either t…

Analysis of IVF/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate Open

Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai , et al. · 2021

Objective To study the influence of endometriosis activity on the pregnancy outcomes of patients with recurrent implantation failure (RIF) in in-vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles. The pregnancy outcome…

A novel homozygous nonsense mutation in zona pellucida 1 (ZP1) causes human female empty follicle syndrome Open

Jing Wang, Xiaoyu Yang, Xueping Sun, Long Ma, Yaoxue Yin , et al. · 2021

The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway Open

Qiqi Cao, Chun Zhao, Congjing Wang, Lingbo Cai, Meng Xia , et al. · 2021

PAT1 homolog 2 (PATL2), encoding an RNA-binding protein, is a repressor involved in the translational regulation of maternal mRNAs during oocyte maturation. Previous studies have reported mutations in PATL2 those led to female infertility …

Intracytoplasmic sperm injection outcomes in patients with orgasmic dysfunction and anejaculation by percutaneous epididymal sperm aspiration (PESA) Open

Jianzheng Fang, Li Shu, Lingbo Cai, Yugui Cui, Jiayin Liu , et al. · 2020

Like TESA, PESA is an appropriate and convenient way to obtain sperm for ICSI for patients with orgasmic dysfunction and anejaculation. Performing ICSI with sperm from the cauda epididymis can achieve favorable clinical pregnancy and live …

Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes Open

Yi Qian, Chao Meng, Lingbo Cai, Yugui Cui, Jiayin Liu , et al. · 2020

Our results provide evidence that higher expression of antioxidants, such as Prdx4, in the FF of IVF patients tends to indicate a higher likelihood of pregnancy through an oocyte quality mechanism.

Coenzyme Q10 supplementation of human oocyte in vitro maturation reduces postmeiotic aneuploidies Open

Long Ma, Lingbo Cai, Mengting Hu, Jing Wang, Jiazi Xie , et al. · 2020

Expression of Target Genes in Cumulus Cells Derived from Human Oocytes with and without Blastocyst Formation Open

Tuan-Ping Zhou, Di Zhang, Lingbo Cai, Yixin Xu, Shao Li , et al. · 2019

Objective: The transcriptional profile of cumulus cells (CCs) during oocyte maturation provides information for predicting oocyte developmental competence. Our previous study using a mouse model indicated that there were nine different gen…

Homozygous missense mutation Arg207Cys in the WEE2 gene causes female infertility and fertilization failure Open

Xiaoyu Yang, Li Shu, Lingbo Cai, Xueping Sun, Yugui Cui , et al. · 2019

Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels Open

Andi Li, Lu Zhang, Jiajia Jiang, Nan Yang, Ying Liu , et al. · 2018

Polycystic ovary syndrome (PCOS) is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandrogenemia. The microenviron…

Establishment of human-embryonic-stem-cell line from mosaic trisomy 9 embryo Open

Boxian Huang, Chunyan Jiang, Aiqin Chen, Yugui Cui, Jiazi Xie , et al. · 2015

Our study showed that chromosomally aberrant embryos could generate a normal hESC line, which would be useful in investigating gene function and embryo development.

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