Yan Li
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View article: Metformin for the treatment of unruptured vertebrobasilar dissecting aneurysm (METTLE): study protocol for a double-blinded randomised controlled trial
Metformin for the treatment of unruptured vertebrobasilar dissecting aneurysm (METTLE): study protocol for a double-blinded randomised controlled trial Open
NCT06405971. Registered on May 9, 2024.
View article: Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma
Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma Open
Our study suggests that CDKN2A has an oncogenic role in ccRCC and may serve as a potential therapeutic target.
View article: Leptin as a key driver for organ fibrogenesis
Leptin as a key driver for organ fibrogenesis Open
Leptin, a hormone primarily secreted by adipocytes, regulates energy balance and systemic metabolism through its interaction with the leptin receptor (LEPR). Beyond these functions, leptin signaling has been implicated in the pathogenesis …
View article: An ensemble machine learning-based risk stratification tool for 30-day mortality prediction in critically ill cardiovascular patients
An ensemble machine learning-based risk stratification tool for 30-day mortality prediction in critically ill cardiovascular patients Open
The ensemble ML model outperformed conventional prognostic tools in predicting 30-day mortality, with SHR augmenting traditional tools but not the ensemble ML model. This approach offers a reliable, interpretable framework for risk stratif…
View article: Non-invasive prediction of invasive lung adenocarcinoma and high-risk histopathological characteristics in resectable early-stage adenocarcinoma by [18F]FDG PET/CT radiomics-based machine learning models: a prospective cohort Study
Non-invasive prediction of invasive lung adenocarcinoma and high-risk histopathological characteristics in resectable early-stage adenocarcinoma by [18F]FDG PET/CT radiomics-based machine learning models: a prospective cohort Study Open
Background: Precise preoperative discrimination of invasive lung adenocarcinoma (IA) from preinvasive lesions (adenocarcinoma in situ [AIS]/minimally invasive adenocarcinoma [MIA]) and prediction of high-risk histopathological features are…
View article: Ultrasound characteristics of endometrial receptivity in patients with intrauterine adhesion following endometrial polyp surgery and their impact on pregnancy
Ultrasound characteristics of endometrial receptivity in patients with intrauterine adhesion following endometrial polyp surgery and their impact on pregnancy Open
Objective This study endeavors to investigate the ultrasound characteristics of endometrial receptivity (ER) in patients with intrauterine adhesion (IUA) following endometrial polyp surgery and their impact on pregnancy. Methods Sixty pati…
View article: The efficacy and safety of inhaled peptide YKYY017 for COVID-19 patients with mild illness: a phase 2 randomized controlled trial
The efficacy and safety of inhaled peptide YKYY017 for COVID-19 patients with mild illness: a phase 2 randomized controlled trial Open
YKYY017 is a SARS-CoV-2 membrane fusion inhibitor. We report efficacy and safety of inhaled YKYY017 for COVID-19 patients with mild to moderate illness from a phase 2 trial (ChiCTR2300075467). 239 patients aged 18-75 years with mostly mild…
View article: Fecal microbiota transplantation: A promising treatment strategy for chronic liver disease
Fecal microbiota transplantation: A promising treatment strategy for chronic liver disease Open
Chronic liver disease has become a global health crisis, with increasing incidence and mortality rates placing a substantial burden on healthcare systems worldwide. A key factor in the progression of chronic liver disease is intestinal mic…
View article: Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study
Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study Open
Objectives The relationships between the triglyceride-glucose (TyG) index, TyG-related parameters of different obesity phenotypes and the risk of type 2 diabetes (T2D) remain unclear. We aimed to determine associations between TyG index, o…
View article: Association between body composition in early pregnancy and the risk of gestational diabetes mellitus
Association between body composition in early pregnancy and the risk of gestational diabetes mellitus Open
Background Gestational diabetes mellitus (GDM) is a common complication during pregnancy that poses serious health risks to both mothers and their offspring. Risk factors for GDM, such as obesity, have been extensively reported. However, t…
View article: Cholesterol metabolism and its role in type 2 diabetes mellitus development
Cholesterol metabolism and its role in type 2 diabetes mellitus development Open
Cholesterol has increasingly been recognized for its pivotal role in the regulation of glucose metabolism. It influences the pathophysiological processes of type 2 diabetes mellitus (T2DM) by affecting pancreatic β-cell function and promot…
View article: Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals
Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals Open
To evaluate the relationship between metformin and the outcome of coronavirus disease 2019 (COVID-19) infection. The study included 413 patients with type 2 diabetes among the 5217 patients enrolled in a COVID-19 study, and analyzed whethe…
View article: Study on the multidrug resistance and transmission factors of Staphylococcus aureus at the ‘animal–environment–human’ interface in the broiler feeding cycle
Study on the multidrug resistance and transmission factors of Staphylococcus aureus at the ‘animal–environment–human’ interface in the broiler feeding cycle Open
Multidrug-resistant Staphylococcus aureus ( S. aureus ) poses an increasingly serious threat to agricultural safety and public health. Based on the concept of “One Health,” this study analyzed the multidrug resistance and transmission fact…
View article: Effect of conjugative transfer of antibiotic resistance genes mediated by plasmids on the microecology of different intestinal segments
Effect of conjugative transfer of antibiotic resistance genes mediated by plasmids on the microecology of different intestinal segments Open
Introduction The conjugative transfer of antibiotic resistance genes (ARGs) mediated by plasmids occurred in different intestinal segments of mice was explored. Methods The location of ARG donor bacteria and ARGs was investigated by qPCR, …
View article: Study on the Mechanisms of Glrα3 in Pain Sensitization of Endometriosis
Study on the Mechanisms of Glrα3 in Pain Sensitization of Endometriosis Open
Endometriosis, often associated with chronic pelvic pain, can lead to anxiety and depression. This study investigates the role and mechanism of Glycine receptor alpha 3 (Glrα3) in the central sensitization of pain in endometriosis, aiming …
View article: WITHDRAWN: Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals
WITHDRAWN: Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals Open
To evaluate the relationship between metformin and the outcome of COVID-19 infection. The study included 413 patients with type 2 diabetes among the 5,217 patients enrolled in a COVID-19 study, and analyzed whether receiving metformin ther…
View article: Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters Open
Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and application of therapeutics remain…
View article: Diagnostic and grading criteria for androgenetic alopecia using dermoscopy
Diagnostic and grading criteria for androgenetic alopecia using dermoscopy Open
Objectives To establish accurate and objective dermoscopic diagnostic criteria and grading standards for males and females with androgenetic alopecia (AGA). Methods Twenty patients each with AGA, diffuse alopecia areata, telogen effluvium,…
View article: Prevalence and factors influencing long COVID among primary healthcare workers after epidemic control policy adjustment in Jiangsu, China
Prevalence and factors influencing long COVID among primary healthcare workers after epidemic control policy adjustment in Jiangsu, China Open
Objective: This study aims to evaluate the prevalence of long COVID infections and their influencing factors among primary HCWs after epidemic control policy adjustment in Jiangsu. Methods: A self-designed questionnaire was administered th…
View article: <i>In situ</i> vaccination caused by diverse irradiation-driven cell death programs
<i>In situ</i> vaccination caused by diverse irradiation-driven cell death programs Open
Interest surrounding the effect of irradiation on immune activation has exponentially grown within the last decade. This includes work regarding mechanisms of the abscopal effect and the success achieved by combination of radiotherapy and …
View article: Risk factors for postpartum posttraumatic stress disorder after emergency admission
Risk factors for postpartum posttraumatic stress disorder after emergency admission Open
Emergency cesarean section, admission to the emergency department after midnight, and cervical dilation were identified as independent risk factors for postpartum PTSD, while analgesic pump use was a protective factor. These findings provi…