Lingfei Hu
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View article: Global Stress Responses Identify the Functionally Divergent Regulators Required for <i>Candida auris</i> Commensalism and Pathogenicity
Global Stress Responses Identify the Functionally Divergent Regulators Required for <i>Candida auris</i> Commensalism and Pathogenicity Open
Given its global distribution and high transmissibility in the environment, Candida auris poses a serious threat to global public health. However, the underlying mechanisms of its adaptive strategies remain poorly understood. Here we delin…
View article: A cell differentiation landscape for monocyte and interstitial macrophage in the lung with diffuse alveolar damage
A cell differentiation landscape for monocyte and interstitial macrophage in the lung with diffuse alveolar damage Open
Diffuse alveolar damage (DAD) is recognized as a deadly type of acute inflammatory lung injury caused by toxic inhalants, but its cellular and molecular pathogenesis remains largely unclear. In this study, by using a mouse model of ricin-i…
View article: The global genomic landscape of hypervirulent <i>Klebsiella pneumoniae</i> from 1932 to 2021
The global genomic landscape of hypervirulent <i>Klebsiella pneumoniae</i> from 1932 to 2021 Open
The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the …
View article: Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia
Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia Open
View article: IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage
IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage Open
Diffuse alveolar damage (DAD), a lethal manifestation of acute lung injury, remains a critical public health concern due to the absence of targeted therapies. However, the underlying cellular and molecular mechanisms responsible for immuno…
View article: Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris
Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris Open
View article: Multi-omics profiling of acute <i>Pseudomonas aeruginosa</i> pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets
Multi-omics profiling of acute <i>Pseudomonas aeruginosa</i> pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets Open
Pseudomonas aeruginosa (PA) is a key pathogen in hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), challenging clinical medicine. This study aims to elucidate the characteristics of the host's innate immun…
View article: Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia
Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia Open
Sonodynamic therapy (SDT) has good feasibility to deeply seated infections, but SDT alone is insufficient being highly effective against multidrug‐resistant (MDR) bacteria. SDT combined with triphenylphosphanium bromide (P + Ph 3 Br − ) is…
View article: Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs
Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs Open
The emergence of multidrug-resistant (MDR) Raoultella isolates is linked to the acquisition of antibiotic resistance genes (ARGs) with plasmids playing a pivotal role in this process. While plasmid-mediated transmission of ARGs in Raoultel…
View article: Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris
Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris Open
The frequent use of antifungal agents has contributed to the emergence of previously rare or unidentified drug-resistant fungal species, such as Candida auris, which presents mortality rates exceeding 40% and antifungal resistance rates su…
View article: Unraveling host-pathogen dynamics in a murine model of septic peritonitis induced by vancomycin-resistant <i>Enterococcus faecium</i>
Unraveling host-pathogen dynamics in a murine model of septic peritonitis induced by vancomycin-resistant <i>Enterococcus faecium</i> Open
Vancomycin-resistant Enterococcus faecium (E. faecium) infection is associated with higher mortality rates. Previous studies have emphasized the importance of innate immune cells and signalling pathways in clearing E. faec…
View article: Mice fatal pneumonia model induced by less-virulent <i>Streptococcus pneumoniae</i> via intratracheal aerosolization
Mice fatal pneumonia model induced by less-virulent <i>Streptococcus pneumoniae</i> via intratracheal aerosolization Open
Aim: Animal models of fatal pneumonia caused by Streptococcus pneumoniae (Spn) have not been reliably generated using many strains of less virulent serotypes.Materials & methods: Pulmonary infection of a less vi…
View article: Changes in the extractability and fractionation of cadmium and copper in a contaminated soil amended with various sugarcane bagasse-based materials
Changes in the extractability and fractionation of cadmium and copper in a contaminated soil amended with various sugarcane bagasse-based materials Open
Heavy-metal contamination in soil has long been a persistent challenge and the utilization of agricultural waste for in-situ stabilization remediation presents a promising approach to tackle this problem. Agricultural wastes exhibit promis…
View article: Comprehensive performance evaluation of six bioaerosol samplers based on an aerosol wind tunnel
Comprehensive performance evaluation of six bioaerosol samplers based on an aerosol wind tunnel Open
Choosing a suitable bioaerosol sampler for atmospheric microbial monitoring has been a challenge to researchers interested in environmental microbiology, especially during a pandemic. However, a comprehensive and integrated evaluation meth…
View article: Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization Open
The COVID-19 pandemic has fostered major advances in vaccination technologies1-4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration4-6. …
View article: Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization Open
The coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs for vaccines that induce mucosal immune responses and single-dose, noninvasive administration. Here, we develop an in…
View article: Frontispiece: Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage (EXP2 3/2023)
Frontispiece: Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage (EXP2 3/2023) Open
This study presents a comprehensive cellular atlas describing the ongoing pulmonary immune responses in the early stages of diffuse alveolar damage. This work indicates a vital role of the hyper-inflammatory fibroblast subset around the br…
View article: Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage
Spatiotemporal single‐cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage Open
Diffuse alveolar damage (DAD) triggers neutrophilic inflammation in damaged tissues of the lung, but little is known about the distinct roles of tissue structural cells in modulating the recruitment of neutrophils to damaged areas. Here, b…
View article: Inhalable vaccine of bacterial culture supernatant extract mediates protection against fatal pulmonary anthrax
Inhalable vaccine of bacterial culture supernatant extract mediates protection against fatal pulmonary anthrax Open
Pulmonary anthrax is the most fatal clinical form of anthrax and currently available injectable vaccines do not provide adequate protection against it. Hence, next-generation vaccines that effectively induce immunity against pulmonary anth…
View article: Time-Course Transcriptome Analysis of the Lungs of Mice Challenged with Aerosols of Methicillin-Resistant Staphylococcus aureus USA300 Clone Reveals Inflammatory Balance
Time-Course Transcriptome Analysis of the Lungs of Mice Challenged with Aerosols of Methicillin-Resistant Staphylococcus aureus USA300 Clone Reveals Inflammatory Balance Open
USA300, a dominant clone of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), is circulating globally and can cause necrotizing pneumonia with high morbidity and mortality. To further reveal the host anti-MRSA infec…
View article: QsvR and OpaR coordinately repress biofilm formation by Vibrio parahaemolyticus
QsvR and OpaR coordinately repress biofilm formation by Vibrio parahaemolyticus Open
Mature biofilm formation by Vibrio parahaemolyticus requires exopolysaccharide (EPS), type IV pili, and capsular polysaccharide (CPS). Production of each is strictly regulated by various control pathways including quorum sensing (QS) and b…
View article: Genomic diversity analysis of IncHI3 plasmids and their derivatives sharing the IncHI3 core backbone
Genomic diversity analysis of IncHI3 plasmids and their derivatives sharing the IncHI3 core backbone Open
Objectives To dissect genomic features of IncHI3 plasmids and their derivatives sharing the IncHI3 core backbone. Methods An extensive genomic comparison was applied to all 20 available sequenced IncHI3 plasmids and their derivatives, incl…
View article: Changes in the Extractability and Fractionation Of Cadmium and Copper in a Contaminated Soil Amended with Various Sugarcane Bagasse-Based Materials
Changes in the Extractability and Fractionation Of Cadmium and Copper in a Contaminated Soil Amended with Various Sugarcane Bagasse-Based Materials Open
View article: Inhalable SARS-CoV-2 vaccines for single-dose dry-powder aerosol immunization and orchestrated mucosal/systemic immune responses
Inhalable SARS-CoV-2 vaccines for single-dose dry-powder aerosol immunization and orchestrated mucosal/systemic immune responses Open
The ongoing coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs of mucosal immune responses and single-dose, non-invasive administration. Here, we develop a SARS-CoV-2 vacci…
View article: Csf2ra deletion attenuates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice
Csf2ra deletion attenuates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice Open
Specific therapeutics are not available for acute lung injury (ALI) induced by ricin toxin (RT). Inhibiting the host immune response in the course of pulmonary ricinosis is hypothesized to be of benefit and can be achieved by impairing gra…
View article: Transcriptomic Analysis of Vibrio parahaemolyticus Underlying the Wrinkly and Smooth Phenotypes
Transcriptomic Analysis of Vibrio parahaemolyticus Underlying the Wrinkly and Smooth Phenotypes Open
We showed that Vibrio parahaemolyticus was able to naturally and reversibly switch between wrinkly and smooth phenotypes and disclosed the gene expression profiles related to wrinkly-smooth switching, showing that the significantly differe…
View article: Expression of Osteopontin and Integrin αvβ3 Receptor in Retina of Diabetic Guinea Pigs with High Myopia
Expression of Osteopontin and Integrin αvβ3 Receptor in Retina of Diabetic Guinea Pigs with High Myopia Open
Introduction: The study aimed to investigate the effect of high myopia on the expression of retinal osteopontin (OPN) and integrin αvβ3 receptor in guinea pigs and determine the relationship between high myopia and diabetic r…
View article: A blaSIM-1 and mcr-9.2 harboring Klebsiella michiganensis strain reported and genomic characteristics of Klebsiella michiganensis
A blaSIM-1 and mcr-9.2 harboring Klebsiella michiganensis strain reported and genomic characteristics of Klebsiella michiganensis Open
As a newly emerging Klebsiella pathogen, more and more Klebsiella michiganensis drug resistant strains have been reported in recent years, which posed serious threats to public health. Here we first reported a multidrug-resistant K. michig…
View article: Innate immune responses against the fungal pathogen Candida auris
Innate immune responses against the fungal pathogen Candida auris Open
View article: Time-Course Transcriptome Analysis of Lungs From Mice Infected With Hypervirulent Klebsiella pneumoniae via Aerosolized Intratracheal Inoculation
Time-Course Transcriptome Analysis of Lungs From Mice Infected With Hypervirulent Klebsiella pneumoniae via Aerosolized Intratracheal Inoculation Open
Hypervirulent Klebsiella pneumoniae (hvKp) can cause life-threatening community-acquired infections among healthy young individuals and is thus of concern for global dissemination. In this study, a mouse model of acute primary hvKp pneumon…