Lingfei Kong
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View article: Case Report: Hydroxychloroquine-induced generalized pustular psoriasis in a pediatric patient with systemic lupus erythematosus
Case Report: Hydroxychloroquine-induced generalized pustular psoriasis in a pediatric patient with systemic lupus erythematosus Open
Hydroxychloroquine (HCQ) therapy is the main treatment for systemic lupus erythematosus (SLE); however, rare adverse effects, including generalized pustular psoriasis (GPP), have been predominantly reported in adults. We herein report the …
View article: Research on Measurement of Coal–Water Slurry Solid–Liquid Two-Phase Flow Based on a Coriolis Flow Meter and a Neural Network
Research on Measurement of Coal–Water Slurry Solid–Liquid Two-Phase Flow Based on a Coriolis Flow Meter and a Neural Network Open
The development of coal–water slurry (CWS), a new type of coal-based chemical product in China, has garnered increasing attention as a potential substitute for petroleum resources. The Coriolis mass flow meter is widely used in industrial …
View article: Identifying pyroptosis-related prognostic genes in the co-occurrence of lung adenocarcinoma and COPD via bioinformatics analysis
Identifying pyroptosis-related prognostic genes in the co-occurrence of lung adenocarcinoma and COPD via bioinformatics analysis Open
View article: Metformin suppresses breast cancer cell proliferation and liver metastasis by up-regulating miR-34a
Metformin suppresses breast cancer cell proliferation and liver metastasis by up-regulating miR-34a Open
View article: Artificial intelligence model predicts M2 macrophage levels and HCC prognosis with only globally labeled pathological images
Artificial intelligence model predicts M2 macrophage levels and HCC prognosis with only globally labeled pathological images Open
Background and aims The levels of M2 macrophages are significantly associated with the prognosis of hepatocellular carcinoma (HCC), however, current detection methods in clinical settings remain challenging. Our study aims to develop a wea…
View article: Identification of varieties of wheat seeds based on multispectral imaging combined with improved YOLOv5
Identification of varieties of wheat seeds based on multispectral imaging combined with improved YOLOv5 Open
View article: Pan-cancer exploration of PNO1: A prospective prognostic biomarker with ties to immune infiltration
Pan-cancer exploration of PNO1: A prospective prognostic biomarker with ties to immune infiltration Open
The partner of NOB1 homolog (PNO1) is an RNA-binding protein that participates in ribosome biogenesis and protein modification. The functions of this molecule are largely unknown in cancers, particularly breast cancer. We employed bioinfor…
View article: Metformin reduces basal subpopulation and attenuates mammary epithelial cell stemness in FVB/N mice
Metformin reduces basal subpopulation and attenuates mammary epithelial cell stemness in FVB/N mice Open
Metformin shows promise in breast cancer prevention, but its underlying mechanisms remain unclear. This study investigated the impact of metformin on the repopulation dynamics of mammary epithelial cells (MECs) and the signaling pathways i…
View article: Stable peptide-assembled nanozyme mimicking dual antifungal actions
Stable peptide-assembled nanozyme mimicking dual antifungal actions Open
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against antimicrobial resistance but suffer from low efficiency and poor stability. Here, we develop peptide nanozymes which mimic the mode of…
View article: Mathematical Model for COVID-19
Mathematical Model for COVID-19 Open
Since the end of 2019, novel coronavirus has started to spread around the world and continue to mutate. From the initial Alpha to Delta and Omicron, it continues to affect our economic, social and spiritual life. In the process of preventi…
View article: Identification of varieties of wheat seeds based on multispectral imaging combined with improved YOLOv5
Identification of varieties of wheat seeds based on multispectral imaging combined with improved YOLOv5 Open
The identification of seed variety is important in wheat production because the growth and yield are highly related with its variety. Traditional discrimination methods for wheat seed varieties were suffered with time consuming and contami…
View article: H-ferritin-nanocaged gadolinium nanoparticles for ultra-sensitive MR molecular imaging
H-ferritin-nanocaged gadolinium nanoparticles for ultra-sensitive MR molecular imaging Open
Rationale: Magnetic resonance imaging (MRI) is a powerful diagnostic technology by providing high-resolution imaging. Although MRI is sufficiently valued in its resolving morphology, it has poor sensitivity for tracking biomarkers. …
View article: Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats
Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats Open
View article: Distribution mechanism of dominant genera and species of bacteria under different river velocity
Distribution mechanism of dominant genera and species of bacteria under different river velocity Open
Flow velocity as the basic hydrodynamic condition significantly affects bacterial proliferation and biofilm formation, yet how different flow velocity influences the attachment and distribution of dominant bacteria in different ecological …
View article: Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity
Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity Open
Amyloid-like assembly is not only associated with pathological events, but also leads to the development of novel nanomaterials with unique properties. Herein, using Fmoc diphenylalanine peptide (Fmoc–F–F) as a minimalistic model, we found…
View article: Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas
Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas Open
View article: Genomic alterations of oligodendrogliomas at distant recurrence
Genomic alterations of oligodendrogliomas at distant recurrence Open
Background Oligodendroglioma is known for its relatively better prognosis and responsiveness to radiotherapy and chemotherapy. However, little is known about the evolution of genetic changes as oligodendroglioma progresses. Methods In this…
View article: Lipid Mediators Metabolic Chaos of Asthmatic Mice Reversed by Rosmarinic Acid
Lipid Mediators Metabolic Chaos of Asthmatic Mice Reversed by Rosmarinic Acid Open
Background and objective: Asthma is a common chronic inflammatory disease of the airways with no known cure. Lipid mediators (LMs) are a kind of inflammatory signaling molecules which are believed to be involved in the development of asthm…
View article: Study of Internal Exposure Biomarkers of Polycyclic Aromatic Hydrocarbons
Study of Internal Exposure Biomarkers of Polycyclic Aromatic Hydrocarbons Open
Due to the high exposure toxicity and individual variability of polycyclic aromatic hydrocarbons (PAHs), it is difficult to accurately characterize the actual exposure of exposed individuals through external exposure detection. In this stu…
View article: The influence of Hyssopus cuspidatus Boriss extract on lipid mediators metabolism network in asthmatic mice
The influence of Hyssopus cuspidatus Boriss extract on lipid mediators metabolism network in asthmatic mice Open
Current drugs do not provide an absolute cure or modify the course of asthma. Hyssopus cuspidatus Boriss extract (SXCF) has been used as Uyghur medicine for several years to treat bronchial asthma. However, very limited research has been c…
View article: Reconstructive types effect the prognosis of patients with tumors in the central and nipple portion of breast cancer? An analysis based on SEER database
Reconstructive types effect the prognosis of patients with tumors in the central and nipple portion of breast cancer? An analysis based on SEER database Open
Introduction The impact of different types of reconstruction, including tissue reconstruction, implant reconstruction and combined reconstruction, on patient survival were not illustrated completely. We tried to investigate the impact of p…
View article: Identification of Wheat Varieties Based on Multispectral Imaging Combined with Improved Yolov5
Identification of Wheat Varieties Based on Multispectral Imaging Combined with Improved Yolov5 Open
View article: Clinicopathological characterization of ten patients with primary malignant melanoma of the esophagus and literature review
Clinicopathological characterization of ten patients with primary malignant melanoma of the esophagus and literature review Open
The correct diagnosis of PMME before surgery is low, and physicians should pay more attention to avoid a misdiagnosis or missed diagnosis. Extended lymph node dissection should be emphasized in surgery for PMME even though the tumor is con…
View article: Gastric mucosal precancerous lesions in <i>Helicobacter pylori</i>-infected pediatric patients in central China: A single-center, retrospective investigation
Gastric mucosal precancerous lesions in <i>Helicobacter pylori</i>-infected pediatric patients in central China: A single-center, retrospective investigation Open
In children and adolescents, gastric mucosal precancerous lesions occurred in 4.33% of H. pylori-infected patients in central China. These cases included atrophic gastritis, intestinal metaplasia, and dysplasia. The data revealed an…
View article: Real‐time longitudinal analysis of human gliomas reveals in vivo genome evolution and therapeutic impact under standardized treatment
Real‐time longitudinal analysis of human gliomas reveals in vivo genome evolution and therapeutic impact under standardized treatment Open
The molecular characterization of glioma genes is essential for properly managing and treating this heterogeneous disease.1, 2 However, the true in vivo evolution of the genome of glioma patients during treatment and its impact on clinical…
View article: Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma
Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma Open
View article: Tracking Glioma Evolution in human brain for precision medicine by integrating real-time in vivo tumour genomes
Tracking Glioma Evolution in human brain for precision medicine by integrating real-time in vivo tumour genomes Open
Background: Targeted therapy of glioma is unsatisfactory due to the variable heterogeneity of tumors. We tracked glioma genomic alterations in vivo to provide a boost to precision medicine. Methods: We collected tumor tissue samples from g…
View article: piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner
piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner Open
View article: FGFR1 Overexpression Induces Cancer Cell Stemness and Enhanced Akt/Erk-ER Signaling to Promote Palbociclib Resistance in Luminal A Breast Cancer Cells
FGFR1 Overexpression Induces Cancer Cell Stemness and Enhanced Akt/Erk-ER Signaling to Promote Palbociclib Resistance in Luminal A Breast Cancer Cells Open
Resistance to CDK4/6 inhibitors (CDKis) is emerging as a clinical challenge. Identification of the factors contributing to CDKi resistance, with mechanistic insight, is of pivotal significance. Recent studies linked aberrant FGFR signaling…
View article: Integrating real‐time in vivo tumour genomes for longitudinal analysis and management of glioma recurrence
Integrating real‐time in vivo tumour genomes for longitudinal analysis and management of glioma recurrence Open
Tumour recurrence is the leading cause of glioma mortality. Current therapies based on excised tumour tissues cannot be lastingly effective due to the waning representativeness of in vitro primary tumours for the in vivo glioma caused by t…