Lihua Xie
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View article: Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition
Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition Open
Smoking promotes TGF-β1-induced small airway remodeling in COPD by driving EMT. Smad7 suppresses this process.
View article: Cuproptosis: mechanisms and links with Alzheimer’s disease
Cuproptosis: mechanisms and links with Alzheimer’s disease Open
Copper, an essential trace element in the human body, plays a crucial role in various metabolic processes, and its homeostasis imbalance is increasingly recognized as being associated with the pathology of Alzheimer’s disease (AD). Notably…
View article: Liu-pao Tea as a Source of Botanical Oviposition Attractants for Aedes Mosquitoes
Liu-pao Tea as a Source of Botanical Oviposition Attractants for Aedes Mosquitoes Open
Oviposition attractants can enhance both the surveillance and control of container-breeding Aedes mosquitoes. Although green tea has been reported to attract Ae. aegypti, the specific bioactive botanical compounds responsible remain uniden…
View article: Efficacy, pharmacokinetics, and safety of nebulized HL231 inhalation solution in patients with chronic obstructive pulmonary disease: a randomized trial
Efficacy, pharmacokinetics, and safety of nebulized HL231 inhalation solution in patients with chronic obstructive pulmonary disease: a randomized trial Open
This study was registered at Chinese Clinical Trials Registration (ChiCTR2300068316) and clinicaltrials.gov (NCT06619210, retrospectively registered).
View article: Association between iron homeostasis and prognosis in patients with chronic obstructive pulmonary disease: a retrospective analysis from MIMIC-IV database
Association between iron homeostasis and prognosis in patients with chronic obstructive pulmonary disease: a retrospective analysis from MIMIC-IV database Open
Introduction Accumulating evidence indicates that inflammatory responses can alter iron-related biomarkers, such as serum iron, ferritin, transferrin, and total iron-binding capacity (TIBC). However, in the context of chronic obstructive p…
View article: Synthesis and Properties of Trinitromethyl‐1 <i>H</i> ‐1,2,4‐Triazole Bridging Nitropyrazole Energetic Salts
Synthesis and Properties of Trinitromethyl‐1 <i>H</i> ‐1,2,4‐Triazole Bridging Nitropyrazole Energetic Salts Open
The polynitroazole plays an important role in the design of high‐energy density materials. A series of nitrogen‐rich salts based on trinitromethyl‐substituted 1 H ‐1,2,4‐triazole bridging nitropyrazole was prepared. These newly synthesized…
View article: Short-Term Effectiveness of Ustekinumab in Crohn’s Disease: Results from a Real-World Retrospective Multicenter Study in China
Short-Term Effectiveness of Ustekinumab in Crohn’s Disease: Results from a Real-World Retrospective Multicenter Study in China Open
Ustekinumab is effective in the short-term treatment of CD patients in China, with first line treatment superior to second line treatment and faster than second line treatment.
View article: Clinical characteristics of Chlamydia psittaci pneumonia and predictors analysis of severe patients: a retrospective observational study
Clinical characteristics of Chlamydia psittaci pneumonia and predictors analysis of severe patients: a retrospective observational study Open
Background With this study, we aimed to explore the clinical features, laboratory examinations, imaging features, and severe predictors of Chlamydia psittaci pneumonia to identify the disease early, shorten the course of illness, and impro…
View article: MicroRNA-21 plays a role in exacerbating chronic obstructive pulmonary disease by regulating necroptosis and apoptosis in bronchial epithelial cells
MicroRNA-21 plays a role in exacerbating chronic obstructive pulmonary disease by regulating necroptosis and apoptosis in bronchial epithelial cells Open
Our findings suggest that miR-21 contributes to the worsening of chronic obstructive pulmonary disease by modulating necroptosis and apoptosis in bronchial epithelial cells, providing a new theoretical basis for the pathogenesis of chronic…
View article: Do CRP gene variants and smoking elevate recurrent stroke risk in minor ischemic stroke patients?
Do CRP gene variants and smoking elevate recurrent stroke risk in minor ischemic stroke patients? Open
The rs2808632 and rs3093059 polymorphisms independently and interactively contribute to an increased risk of recurrent minor stroke. Furthermore, the interaction between rs3093059 SNP and smoking status significantly influenced stroke recu…
View article: Angiographic Microvascular Resistance Is an Independent Predictor of Adverse Clinical Outcomes After Transcatheter Aortic Valve Replacement
Angiographic Microvascular Resistance Is an Independent Predictor of Adverse Clinical Outcomes After Transcatheter Aortic Valve Replacement Open
Background The coronary microcirculatory resistance index plays a crucial role in predicting patient prognosis. Coronary angiography‐based methods for assessing coronary microcirculatory function offer advantages such as simplicity and cos…
View article: Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi‐Center PANDA III Trial
Functional Complete Revascularization as Determined by an Optimized Scoring System After Revascularization: A Post Hoc Analysis from Multi‐Center PANDA III Trial Open
Functional complete revascularization (CR) after percutaneous coronary intervention (PCI) as determined by classic residual functional SYNTAX score (c‐rFSS) has been associated with improved prognosis. In this study, the c‐rFSS algorithm i…
View article: COPD-ES Questionnaire Based COPD Patients Management in Stable Phrase Improves Disease Group Classification
COPD-ES Questionnaire Based COPD Patients Management in Stable Phrase Improves Disease Group Classification Open
The study highlights the importance of patient-centered education with our COPD-ES questionnaire in improving COPD management outcomes.
View article: Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking
Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking Open
These findings suggest that melatonin can diminish lung tissue damage, apoptosis, and inflammatory responses induced by passive smoking, as well as decrease the expression of lung cancer-related genes. Further experimental investigations i…
View article: Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking
Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking Open
Background Passive smoke has a significant impact on lung function and constitutes a critical public health issue, as smoking generates free radicals that damage the lungs and other tissues. Currently, limited research exists on whether th…
View article: Do CRP Gene Variants and Smoking Elevate Recurrent Stroke Risk in Minor Ischemic Stroke Patients?
Do CRP Gene Variants and Smoking Elevate Recurrent Stroke Risk in Minor Ischemic Stroke Patients? Open
Background Minor ischemic strokes, though initially presenting with limited symptoms, carry a significant risk of recurrence, potentially leading to severe disability. However, the association of CRP gene variations in predicting the risk …
View article: Identification of early predictive biomarkers for severe cytokine release syndrome in pediatric patients with chimeric antigen receptor T-cell therapy
Identification of early predictive biomarkers for severe cytokine release syndrome in pediatric patients with chimeric antigen receptor T-cell therapy Open
CAR-T cell therapy is a revolutionary new treatment for hematological malignancies, but it can also result in significant adverse effects, with cytokine release syndrome (CRS) being the most common and potentially life-threatening. The ide…
View article: A Novel Edge Laplacian-based Approach for Adaptive Formation Control of Uncertain Multi-agent Systems with Unified Relative Error Performance
A Novel Edge Laplacian-based Approach for Adaptive Formation Control of Uncertain Multi-agent Systems with Unified Relative Error Performance Open
For most existing prescribed performance formation control methods, performance requirements are not directly imposed on the relative states between agents but on the consensus error, which lacks a clear physical interpretation of their so…
View article: Textbook outcomes in patients with a cesarean scar pregnancy: A comprehensive analysis from a single Eastern center
Textbook outcomes in patients with a cesarean scar pregnancy: A comprehensive analysis from a single Eastern center Open
Background Quality medical care is crucial in evaluating clinical results. This study assessed the value of medical quality control using the comprehensive indicator "textbook outcome" (TO) in patients with a cesarean scar pregnancy (CSP).…
View article: Traditional Chinese medicine lowering lipid levels and cardiovascular events across baseline lipid levels among coronary heart disease: a meta-analysis of randomized controlled trials
Traditional Chinese medicine lowering lipid levels and cardiovascular events across baseline lipid levels among coronary heart disease: a meta-analysis of randomized controlled trials Open
Background Dyslipidemia is a critical driver in the development of coronary heart disease (CHD), which further exacerbates the risk of major adverse cardiovascular events (MACEs). Chinese herbal medicine (CHM) plays an important role in th…
View article: Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition
Smad7 ameliorate small airway remodeling in COPD by modulating epithelial-mesenchymal transition Open
Small airway remodeling is widely recognized as one of the major pathological changes 11 in chronic obstructive pulmonary disease (COPD), yet the underlying mechanisms remain 12 unclear. In the present study, we observed higher levels of e…
View article: Robust mixed H2/H-infinity control of 2-dimensional systems in Roesser model
Robust mixed H2/H-infinity control of 2-dimensional systems in Roesser model Open
The H2 performance specification for one-dimensional systems has been known to be analytically and practically meaningful and widely used in the analysis and design of control and filtering systems. However, it is still of little use in th…
View article: Impact of Relative Improvement in Quantitative Flow Ratio on Clinical Outcomes After Percutaneous Coronary Intervention ― A Subanalysis of the PANDA III Trial ―
Impact of Relative Improvement in Quantitative Flow Ratio on Clinical Outcomes After Percutaneous Coronary Intervention ― A Subanalysis of the PANDA III Trial ― Open
Relative improvement of coronary physiology assessed by QRR showed applicability in prognostication. Categorical classification of coronary physiology could provide information for risk stratification of CAD patients.
View article: Quantitative flow ratio as a continuous predictor of myocardial infarction
Quantitative flow ratio as a continuous predictor of myocardial infarction Open
The present study demonstrated a continuous, inverse relationship between the QFR value of a vessel and its subsequent risk for MI, and PCI, compared to medical therapy, reduced this risk beginning at a QFR value of 0.64. These novel findi…