Lingfeng Zhong
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View article: Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity
Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity Open
Objectives Although extensive research on septic cardiomyopathy has been conducted, effective therapies are still limited. Ubiquitin‐specific peptidase 20 (USP20), a deubiquitinating enzyme, is critical in regulating protein ubiquitination…
View article: Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination
Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination Open
Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates the role and mechanism of deubiquitinating enzyme (DUB) ubiquitin‐specific protea…
View article: Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes
Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes Open
Background Myocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐spe…
View article: Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3-CARM1 axis
Cardiomyocyte-enriched USP20 ameliorates pathological cardiac hypertrophy by targeting STAT3-CARM1 axis Open
Pathological cardiac hypertrophy can lead to heart failure. The molecular mechanisms underlying pathological cardiac hypertrophy remain undefined. This study aimed to examine the role and molecular mechanisms of a deubiquitinating enzyme (…
View article: Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF-κB Axis
Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF-κB Axis Open
BACKGROUND: Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is a vital factor in determining the fate of atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis is a programmed cell death,…
View article: Multicomponent comprehensive confirms that erythroferrone is a molecular biomarker of pan-cancer
Multicomponent comprehensive confirms that erythroferrone is a molecular biomarker of pan-cancer Open
All vertebrates organisms produce erythroferrone, a secretory hormone with structure-related functions during iron homeostasis. However, limited knowledge exists regarding the effect of this hormone on the occurrence and progression of can…
View article: Compressor Performance Prediction Based on the Interpolation Method and Support Vector Machine
Compressor Performance Prediction Based on the Interpolation Method and Support Vector Machine Open
Compressors are important components in various power systems in the field of energy and power. In practical applications, compressors often operate under non-design conditions. Therefore, accurate calculation on performance under various …
View article: Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis
Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis Open
Pyroptosis serves a crucial function in various types of ischemia and reperfusion injuries. Oridonin, a tetracycline diterpene derived from Rabdosia rubescens, can significantly inhibit the aggregation of NLRP3-mediated inflammasome. This …
View article: Effects of Low Pressure Injection on Fuel Atomization and Mixture Formation for Heavy Fuel Engines
Effects of Low Pressure Injection on Fuel Atomization and Mixture Formation for Heavy Fuel Engines Open
The application of direct injection (DI) technology can effectively improve the atomization effect of heavy fuel to reduce the fuel loss of heavy fuel engines (HFE). The fuel spray characteristics directly affect the combustion performance…
View article: GSDMD (Gasdermin D) Mediates Pathological Cardiac Hypertrophy and Generates a Feed-Forward Amplification Cascade via Mitochondria-STING (Stimulator of Interferon Genes) Axis
GSDMD (Gasdermin D) Mediates Pathological Cardiac Hypertrophy and Generates a Feed-Forward Amplification Cascade via Mitochondria-STING (Stimulator of Interferon Genes) Axis Open
Background: Cardiac hypertrophy is initially an adaptive response of cardiomyocytes to neurohumoral or hemodynamic stimuli. Evidence indicates that Ang II (angiotensin II) or pressure overload causes GSDMD (gasdermin D) activation in cardi…
View article: Bicyclol Attenuates Obesity-induced Cardiomyopathy via Inhibiting NF-κB and MAPK Signaling Pathways
Bicyclol Attenuates Obesity-induced Cardiomyopathy via Inhibiting NF-κB and MAPK Signaling Pathways Open
Purpose: Schisandra is a well-known traditional Chinese medicine in East Asia. As a traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol is well known for its significant anti-inflammatory effect. Chr…
View article: Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy
Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy Open
Cardiac hypertrophy is an adaptive cardiac response that accommodates the variable hemodynamic demands of the human body during extended periods of preload or afterload increase. In recent years, an increasing number of studies have pointe…
View article: GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation
GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation Open
Myocardial dysfunction is a serious consequence of sepsis and contributes to high mortality. Currently, the molecular mechanism of myocardial dysfunction induced by sepsis remains unclear. In the present study, we investigated the role of …
View article: IDDF2021-ABS-0208 Development of an automatic system to fast quantify marking and incision during endoscopic submucosal dissection
IDDF2021-ABS-0208 Development of an automatic system to fast quantify marking and incision during endoscopic submucosal dissection Open
Background Facilitating accurate location of marking points and circumferential incision in the mucosa at a certain distance outside the boundary of the lesion is important to ensure the quality of endoscopic submucosal dissection (ESD). H…