Liming Tang
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View article: LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBPα Axis
LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBPα Axis Open
Our findings reveal that LRRFIP1 plays a crucial inhibitory role in WAD by negatively regulating the E2F6/C/EBPα axis. This discovery not only enriches our understanding of the molecular networks governing WAD but also holds great promise …
View article: Identification of SDC4 as a potential target for obesity via integrated analysis of the lncRNA-miRNA-mRNA network in visceral adipose tissue
Identification of SDC4 as a potential target for obesity via integrated analysis of the lncRNA-miRNA-mRNA network in visceral adipose tissue Open
Obesity is a major global health issue. This study aimed to elucidate its molecular mechanisms by analysing the expression of lncRNAs, miRNAs, and mRNAs in visceral adipose tissue. Through integrated transcriptome sequencing and bioinforma…
View article: Predicting biliary stricture after liver transplantation based on CT imaging features combined with clinicopathological factors
Predicting biliary stricture after liver transplantation based on CT imaging features combined with clinicopathological factors Open
The nomogram based on independent risk factors effectively identified patients at high risk of BS post-liver transplantation.
View article: Phonon-limited carrier mobility modeling of two-dimensional semiconductors based on first principles
Phonon-limited carrier mobility modeling of two-dimensional semiconductors based on first principles Open
Two-dimensional semiconductors are set to form the foundation of next-generation electronic and optoelectronic devices such as field-effect transistors, solar cells, and light-emitting devices. carrier mobility is one of the key properties…
View article: Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression
Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression Open
Introduction: Lung adenocarcinoma remains a significant public health concern, necessitating novel therapeutic approaches. Neuregulin 4 (NRG4), a secreted protein of the epidermal growth factor family, is recognized for its roles in metabo…
View article: Effect of weight loss following Roux-en-Y gastric bypass on cancer risk: A Mendelian randomization study
Effect of weight loss following Roux-en-Y gastric bypass on cancer risk: A Mendelian randomization study Open
Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss and the prevention or promotion of cancer. We investigated the causa…
View article: Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study
Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study Open
Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non‐di…
View article: Causal relationship between inflammatory cytokines, metabolites and arrhythmia: a mendelian randomization study
Causal relationship between inflammatory cytokines, metabolites and arrhythmia: a mendelian randomization study Open
Background This study aims to explore the causal relationships between inflammatory cytokines (ICs), metabolites, and the risk of arrhythmia through Mendelian Randomization (MR) analysis. Methods The causal associations were analyzed using…
View article: Sodium Orthovanadate Mitigates Nonalcoholic Fatty Liver Disease by Enhancing Autophagy
Sodium Orthovanadate Mitigates Nonalcoholic Fatty Liver Disease by Enhancing Autophagy Open
Sodium orthovanadate (SOV) has been investigated in recent research for its therapeutic efficacy in treating metabolic disorders. Considering the rising prevalence of non-alcoholic fatty liver disease (NAFLD), the effects of SOV on NAFLD r…
View article: Trends and risk factors analysis of aortic aneurysm mortality in China over thirty years: based on the global burden of disease 2019 data
Trends and risk factors analysis of aortic aneurysm mortality in China over thirty years: based on the global burden of disease 2019 data Open
Objectives This study aims to analyse the variation in mortality burden of aortic aneurysms (AAs) and explore the associated risk factors based on Global Burden of Disease (GBD) 2019 data, investigating the mortality burden of AA in China.…
View article: Potential value and advances in research on bone mineral density (BMD) measurement in the auxiliary clinical assessment of hepatocellular carcinoma
Potential value and advances in research on bone mineral density (BMD) measurement in the auxiliary clinical assessment of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide and its prognosis is highly heterogeneous, being related not only to underlying chronic liver disease but also to the severity of cancer cachexia. Nutriti…
View article: Analysis of prognostic factors and construction of prognostic models for invasive lobular carcinoma of the breast
Analysis of prognostic factors and construction of prognostic models for invasive lobular carcinoma of the breast Open
Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) account for most cases of breast cancer. However, there is ongoing debate about any potential variations in overall survival (OS) between ILC and IDC. This study aimed to…
View article: Zinc Deficiency After Bariatric Surgery: A Systematic Review and Meta-analysis
Zinc Deficiency After Bariatric Surgery: A Systematic Review and Meta-analysis Open
Bariatric surgery has become an effective method for treating severe obesity and its related complications. While the effectiveness and safety of BS have been widely confirmed, micronutrient deficiency has emerged as a long-term complicati…
View article: Analysis of prognostic factors and construction of prognostic models for breast invasive lobular carcinoma
Analysis of prognostic factors and construction of prognostic models for breast invasive lobular carcinoma Open
Purpose: Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) account for most breast cancers. However, there is ongoing controversy regarding the differences in overall survival (OS) between ILC and IDC. The aim of this st…
View article: <scp>YTHDF1</scp> mediates <scp><i>N</i>‐methyl‐<i>N</i></scp>‐nitrosourea‐induced gastric carcinogenesis by controlling <scp>HSPH1</scp> translation
<span>YTHDF1</span> mediates <span><i>N</i>‐methyl‐<i>N</i></span>‐nitrosourea‐induced gastric carcinogenesis by controlling <span>HSPH1</span> translation Open
YT521‐B homology (YTH) domain family (YTHDF) proteins serve as readers that directly recognise m6A modifications. In this study, we aim to probe the role of YTHDF1 in environmental carcinogen‐induced malignant transformation of gastric cel…
View article: Correlations between depressive disorder, obstructive sleep apnea, and hypothalamic inflammation
Correlations between depressive disorder, obstructive sleep apnea, and hypothalamic inflammation Open
Obesity is a significant public health concern in China, with a 2.5-fold increase in prevalence over the past 30 years. This increase corresponds to a rise in the prevalence of obstructive sleep apnea (OSA). This study aims to investigate …
View article: Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma
Involvement and targeted intervention of benzo(a)pyrene-regulated apoptosis related proteome modification and muti-drug resistance in hepatocellular carcinoma Open
During the development of hepatocellular carcinoma (HCC), the mutual adaptation and interaction of HCC cells and the microenvironment play an important role. Benzo(a)pyrene (B[a]P) is a common environmental pollutant, which can induce the …
View article: Histone Deacetylase Inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1
Histone Deacetylase Inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1 Open
Metastasis leads to high mortality of lung adenocarcinoma patients. Histone deacetylases are reliable targets of anti-tumor drugs, and histone deacetylase inhibitors (HDACi) have become a hot field of anti-tumor drug research. However, the…
View article: Screening of Biomarkers in Liver Tissue after Bariatric Surgery Based on WGCNA and SVM-RFE Algorithms
Screening of Biomarkers in Liver Tissue after Bariatric Surgery Based on WGCNA and SVM-RFE Algorithms Open
As the most common chronic liver disease around the world, nonalcoholic fatty liver disease (NAFLD) has a close connection with obesity, diabetes, and metabolic syndrome. Bariatric surgery (BS) is considered to be the most effective treatm…