Li Kang
YOU?
Author Swipe
View article: Eplerenone improves kidney function and cardiac performance in obese male mice
Eplerenone improves kidney function and cardiac performance in obese male mice Open
Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated card…
View article: Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice
Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice Open
Objective: Obesity induces hypothyroidism with unknown mechanisms. This study investigates the role of (Receptor for Hyaluronan-Mediated Motility (RHAMM) in obesity-associated thyroid dysfunction, focusing on hepatic oxidative stress. Meth…
View article: The functional divergence of plant ESCRT components TOL3, SNF7.1, and VPS4 during salt stress response
The functional divergence of plant ESCRT components TOL3, SNF7.1, and VPS4 during salt stress response Open
Salinity, a major abiotic stressor, impacts protein trafficking and alters transport routes. The endosomal sorting complex required for transport (ESCRT)is a key player for membrane protein sorting and is increasingly recognized as pivotal…
View article: Comprehensive Measurement of the Reactor Antineutrino Spectrum and Flux at Daya Bay
Comprehensive Measurement of the Reactor Antineutrino Spectrum and Flux at Daya Bay Open
This Letter reports the precise measurement of reactor antineutrino spectrum and flux based on the full data set of 4.7 million inverse-beta-decay (IBD) candidates collected at Daya Bay near detectors. Expressed in terms of the IBD yield p…
View article: O‐linked β‐N‐acetylglucosamine (O‐<scp>GlcNAc</scp>) modification: Emerging pathogenesis and a therapeutic target of diabetic nephropathy
O‐linked β‐N‐acetylglucosamine (O‐<span>GlcNAc</span>) modification: Emerging pathogenesis and a therapeutic target of diabetic nephropathy Open
Aims O‐Linked β‐N‐acetylglucosamine (O‐GlcNAc) modification, a unique post‐translational modification of proteins, is elevated in diabetic nephropathy. This review aims to summarize the current knowledge on the mechanisms by which O‐GlcNAc…
View article: Characterization of chicken <i>Relaxin3</i> gene: mRNA expression and response to reproductive hormone treatment in ovarian granulosa cells, and single nucleotide polymorphisms associated with egg laying traits in hens
Characterization of chicken <i>Relaxin3</i> gene: mRNA expression and response to reproductive hormone treatment in ovarian granulosa cells, and single nucleotide polymorphisms associated with egg laying traits in hens Open
As a protein structurally similar to insulin, relaxin3 (RLN3) plays a role in promoting arousal, suppressing depressive or anxious behaviors. Two studies revealed the increase of RLN3 expression during chicken follicle selection. In this s…
View article: A Novel Role of Hyaluronan and its Membrane Receptors, CD44 and RHAMM in Obesity-Related Glomerulopathy
A Novel Role of Hyaluronan and its Membrane Receptors, CD44 and RHAMM in Obesity-Related Glomerulopathy Open
Obesity-related glomerulopathy (ORG) contributes to diabetic nephropathy and kidney cancer, leading to chronic/end-stage kidney disease. To date, treatments for ORG are limited because of incomplete understanding of the disease pathogenesi…
View article: Limiting extracellular matrix expansion in diet-induced obese mice reduces cardiac insulin resistance and prevents myocardial remodelling
Limiting extracellular matrix expansion in diet-induced obese mice reduces cardiac insulin resistance and prevents myocardial remodelling Open
View article: Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways
Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways Open
CD44, a cell surface adhesion receptor and stem cell biomarker, is recently implicated in chronic metabolic diseases. Ablation of CD44 ameliorates adipose tissue inflammation and insulin resistance in obesity. Here, we investigated cell ty…
View article: Search for a sub-eV sterile neutrino using Daya Bay's full dataset
Search for a sub-eV sterile neutrino using Daya Bay's full dataset Open
This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, w…
View article: P4 Genetic deletion of hyaluronan receptor RHAMM improves glucose tolerance and cardiac performance in vivo
P4 Genetic deletion of hyaluronan receptor RHAMM improves glucose tolerance and cardiac performance in vivo Open
Extracellular matrix (ECM) remodelling has recently emerged as an important contributor to insulin resistance. Systemic insulin resistance is associated with abnormalities in cardiac function. However, the role of cardiac ECM remodelling …
View article: AKT1 as a Therapeutic Target for Platinum-Resistant SOX2 Positive Ovarian Cancer Cells
AKT1 as a Therapeutic Target for Platinum-Resistant SOX2 Positive Ovarian Cancer Cells Open
View article: Oral Delivery of Lactobacillus Rhamnosus GG Loaded Bilayer Microgels for Targeted Therapy Ofulcerative Colitis
Oral Delivery of Lactobacillus Rhamnosus GG Loaded Bilayer Microgels for Targeted Therapy Ofulcerative Colitis Open
View article: Niaodukang Mixture Inhibits Micro-Inflammation in Ckd Rats by Enhancing Mir-146a Levels in Enterogenous Exosomes
Niaodukang Mixture Inhibits Micro-Inflammation in Ckd Rats by Enhancing Mir-146a Levels in Enterogenous Exosomes Open
View article: Latencies to the first interictal epileptiform discharges recorded by the electroencephalography in different epileptic patients
Latencies to the first interictal epileptiform discharges recorded by the electroencephalography in different epileptic patients Open
View article: Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice
Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice Open
Increased deposition of extracellular matrix (ECM) components such as collagens and hyaluronan contributes to the pathogenesis of obesity-associated insulin resistance in muscle, liver, and adipose tissue. Despite the significance of the h…
View article: Characterization of HIV-1 CRF02_AG/A3/G unique recombinant forms identified among children in Larkana, Pakistan
Characterization of HIV-1 CRF02_AG/A3/G unique recombinant forms identified among children in Larkana, Pakistan Open
Co-circulation of different human immunodeficiency virus type 1 HIV-1 subtypes among infected populations can lead to the generation of new recombinants. In Pakistan, subtype A1 and CRF02_AG are the dominant strains circulating among key p…
View article: Deletion of CD44 promotes adipogenesis by regulating PPARɣ and cell cycle-related pathways
Deletion of CD44 promotes adipogenesis by regulating PPARɣ and cell cycle-related pathways Open
CD44, a cell surface adhesion receptor and stem cell biomarker, is recently implicated in chronic metabolic diseases. Ablation of CD44 ameliorates adipose tissue inflammation and insulin resistance in obesity. Here, we investigated cell ty…
View article: Identification of potential biomarkers associated with CD4+ T cell infiltration in myocardial ischemia-reperfusion injury using bioinformation analysis
Identification of potential biomarkers associated with CD4+ T cell infiltration in myocardial ischemia-reperfusion injury using bioinformation analysis Open
In this study, RNA sequencing (RNA-Seq) data at different time points after reperfusion were subjected to a series of bioinformatics methods such as PPI network, WGCNA module, etc., and CLEC5A, a pivotal gene associated with CD4
View article: Extracellular matrix remodelling in obesity and metabolic disorders
Extracellular matrix remodelling in obesity and metabolic disorders Open
Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This revi…
View article: Acute stress induces an inflammation dominated by innate immunity represented by neutrophils in mice
Acute stress induces an inflammation dominated by innate immunity represented by neutrophils in mice Open
It is well known that psychological stress could affect the immune system and then regulate the disease process. Previous studies mostly focused on the effects of chronic stress on diseases and immune cells. How acute stress affects the im…
View article: The membrane receptor CD44: novel insights into metabolism
The membrane receptor CD44: novel insights into metabolism Open
View article: A Method for Assaying of Protein Kinase Activity In Vivo and Its Use in Studies of Signal Transduction in Strawberry Fruit Ripening
A Method for Assaying of Protein Kinase Activity In Vivo and Its Use in Studies of Signal Transduction in Strawberry Fruit Ripening Open
Strawberry (Fragaria × ananassa) fruit ripening is regulated by a complex of cellular signal transduction networks, in which protein kinases are key components. Here, we report a relatively simple method for assaying protein kinase activit…
View article: pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production
pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production Open
Inflammatory factors and type I interferons (IFNs) are key components of host antiviral innate immune responses, which can be released from the pathogen-infected macrophages. African swine fever virus (ASFV) has developed various strategie…
View article: Review for "Comparative transcriptomic analysis of ovaries from high and low egg‐laying Lingyun black‐bone chickens"
Review for "Comparative transcriptomic analysis of ovaries from high and low egg‐laying Lingyun black‐bone chickens" Open
View article: Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice
Adipocyte integrin-linked kinase plays a key role in the development of diet-induced adipose insulin resistance in male mice Open
These data show that adipocyte ILK is important for regulating HF diet-mediated insulin resistance in AT in a manner consistent with AT function.
View article: Additional file 2 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing
Additional file 2 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing Open
Additional file 2. Primers used in this study.
View article: Additional file 5 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing
Additional file 5 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing Open
Additional file 5. Nucleotide sequence similarities between homology units by pairwise alignment.
View article: Additional file 4 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing
Additional file 4 of Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing Open
Additional file 4. Detailed information of the germline Vγ, Jγ, and Cγ gene segments retrieved from genomic sequences of red jungle fowl (GRCg6a).
View article: Collagen 24 α1 Is Increased in Insulin-Resistant Skeletal Muscle and Adipose Tissue
Collagen 24 α1 Is Increased in Insulin-Resistant Skeletal Muscle and Adipose Tissue Open
Aberrant extracellular matrix (ECM) remodelling in muscle, liver and adipose tissue is a key characteristic of obesity and insulin resistance. Despite its emerging importance, the effective ECM targets remain largely undefined due to limit…