Lingjing Chen
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View article: Interim analysis of a Phase I/II study of tafasitamab with lenalidomide in patients with relapsed central nervous system lymphoma
Interim analysis of a Phase I/II study of tafasitamab with lenalidomide in patients with relapsed central nervous system lymphoma Open
Introduction The development of novel, effective and well-tolerated biological strategies to treat primary and secondary CNS lymphoma (CNSL) is a significant priority. We are evaluating tafasitamab, a humanized anti-CD19 monoclonal antibod…
View article: Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma
Identification of genomic biomarkers of disease progression and survival in primary CNS lymphoma Open
The determination of the genetic subtypes of primary central nervous system lymphoma (PCNSL) and their relationship to differential chemoimmunotherapeutic response has not been established. There is a particular need for genomic biomarkers…
View article: BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models
BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models Open
There is a significant unmet need for more effective therapeutic strategies for relapsed and refractory primary and secondary CNS lymphomas. Bruton's tyrosine kinase (BTK) is a key driver of NF-kB activation and an important target in prim…
View article: Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma
Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma Open
CNS lymphomas remain among the deadliest forms of Non-Hodgkin lymphoma. Factors contributing to therapeutic resistance include the tumor microenvironment, including tumor-associated macrophages and microglia, which may display an immunosup…
View article: Long-term prescribed drug use in stage I–III rectal cancer patients in Sweden, with a focus on bowel-regulating drugs after surgical and oncological treatment
Long-term prescribed drug use in stage I–III rectal cancer patients in Sweden, with a focus on bowel-regulating drugs after surgical and oncological treatment Open
Purpose To describe long-term prescribed drug use after rectal cancer treatment. Methods We identified 12,871 rectal cancer patients without distant metastasis between 2005 and 2016 and 64,341 matched population comparators using CRCBaSe (…
View article: Invasive pneumococcal disease among the elderly in the later era of paediatric pneumococcal conjugate vaccination—A longitudinal study over 10 years based on public surveillance data in the Nordics
Invasive pneumococcal disease among the elderly in the later era of paediatric pneumococcal conjugate vaccination—A longitudinal study over 10 years based on public surveillance data in the Nordics Open
Background Pneumococcal conjugate vaccines (PCVs) have proven effective in preventing both non-invasive and invasive pneumococcal disease (IPD) in small children and in older age groups. However, long-term observations and country comparis…
View article: Labour market integration among young adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) at working age
Labour market integration among young adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) at working age Open
The aims were to investigate patterns of labour market integration following an adult diagnosis of attention-deficit/hyperactivity disorder (ADHD) and its relation to sociodemographic factors and comorbid disorders. Methods Multiple Swedis…
View article: Supplemental Figure 1 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Supplemental Figure 1 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Supplemental Figure 1. Elevated C3a des-arg concentration in CSF is associated with shorter progression-free survival in newly-diagnosed patients with CNS involvement of aggressive non-Hodgkin’s lymphoma (N=35). The survival for the seve…
View article: Supplementary Figure 1 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Supplementary Figure 1 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Supplementary Figure S1. Annual distribution of patients by extent of annual work loss (0, 1-180, 181-359 and >360 days) from two years before to five years after rectal cancer diagnosis for relapse-free patients without pre-diagnostic wor…
View article: Supplemental Figure 1 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Supplemental Figure 1 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Supplemental Figure 1. Elevated C3a des-arg concentration in CSF is associated with shorter progression-free survival in newly-diagnosed patients with CNS involvement of aggressive non-Hodgkin’s lymphoma (N=35). The survival for the seve…
View article: Data from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Data from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Purpose: To elucidate the mechanistic basis for efficacy of intrathecal rituximab. We evaluated complement activation as well as the pharmacokinetics of intraventricular rituximab in patients who participated in two phase 1 multicenter stu…
View article: Data from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Data from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Background: The number of working-age rectal cancer survivors is increasing due to early detection and improved treatment. However, work loss duration and predictors among them have not been studied thoroughly.Methods: We identified 3,438 …
View article: Data from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Data from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Background: The number of working-age rectal cancer survivors is increasing due to early detection and improved treatment. However, work loss duration and predictors among them have not been studied thoroughly.Methods: We identified 3,438 …
View article: Supplemental Figure 2 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Supplemental Figure 2 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Supplemental Figure 2. Effect of hypothetical brain tissue volume (V3) on rituximab disposition in CSF, serum and brain tissue after intraventricular administration. Figure 2A. V3 = 0 ml. Figure 2B. V3 = 320 ml. Figure 2C. V3 = 5000 ml.
View article: Supplementary Table 1 and Table 2 and Table 3 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Supplementary Table 1 and Table 2 and Table 3 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Supplementary Table S1. Numbers of patients at risk and mean days of work loss for clinical subgroups among relapse-free patients without pre-diagnostic work loss between 2 years before diagnosis and 5 years after diagnosis. Supplementary …
View article: Supplementary Figure 1 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Supplementary Figure 1 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Supplementary Figure S1. Annual distribution of patients by extent of annual work loss (0, 1-180, 181-359 and >360 days) from two years before to five years after rectal cancer diagnosis for relapse-free patients without pre-diagnostic wor…
View article: Data from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Data from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Purpose: To elucidate the mechanistic basis for efficacy of intrathecal rituximab. We evaluated complement activation as well as the pharmacokinetics of intraventricular rituximab in patients who participated in two phase 1 multicenter stu…
View article: Supplemental Figure 2 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma
Supplemental Figure 2 from Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma Open
Supplemental Figure 2. Effect of hypothetical brain tissue volume (V3) on rituximab disposition in CSF, serum and brain tissue after intraventricular administration. Figure 2A. V3 = 0 ml. Figure 2B. V3 = 320 ml. Figure 2C. V3 = 5000 ml.
View article: Supplementary Table 1 and Table 2 and Table 3 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss
Supplementary Table 1 and Table 2 and Table 3 from Work Loss Duration and Predictors Following Rectal Cancer Treatment among Patients with and without Prediagnostic Work Loss Open
Supplementary Table S1. Numbers of patients at risk and mean days of work loss for clinical subgroups among relapse-free patients without pre-diagnostic work loss between 2 years before diagnosis and 5 years after diagnosis. Supplementary …
View article: Differences in all-cause and cause-specific mortality due to external causes and suicide between young adult refugees, non-refugee immigrants and Swedish-born young adults: The role of education and migration-related factors
Differences in all-cause and cause-specific mortality due to external causes and suicide between young adult refugees, non-refugee immigrants and Swedish-born young adults: The role of education and migration-related factors Open
Background International migration has increased during the past years and little is known about the mortality of young adult immigrants and refugees that came to Sweden as children. This study aimed to investigate 1) the risk of all-cause…
View article: Long-term diagnosis-specific sickness absence, disability pension, and healthcare use in 1305 young adult childhood cancer survivors and in 6430 references; a Swedish ten-year prospective cohort study
Long-term diagnosis-specific sickness absence, disability pension, and healthcare use in 1305 young adult childhood cancer survivors and in 6430 references; a Swedish ten-year prospective cohort study Open
Background Childhood cancer survivors (CCS) are at high risk of chronic health conditions. We aimed to explore young adult CCS’ and matched references’ future diagnoses-specific healthcare use, sickness absence (SA), and disability pension…
View article: Sickness absence and disability pension trajectories in childhood cancer survivors and references- a Swedish prospective cohort study
Sickness absence and disability pension trajectories in childhood cancer survivors and references- a Swedish prospective cohort study Open
Background Childhood cancer survivors are at high risk of chronic health conditions. We aimed to explore future long-term sickness absence and disability pension in young adult childhood cancer survivors and matched references. Methods We …
View article: Differences in labour market marginalisation between refugees, non-refugee immigrants and Swedish-born youth: Role of age at arrival and residency duration
Differences in labour market marginalisation between refugees, non-refugee immigrants and Swedish-born youth: Role of age at arrival and residency duration Open
Aims: We investigated if the risk of long-term unemployment (LTU) and disability pension (DP) differs between young refugees and non-refuge immigrants compared to the Swedish-born. The role of age at arrival, duration of residency and morb…
View article: Risk Factors for Disability Pension among Young Adults Diagnosed with Attention-deficit Hyperactivity Disorder (ADHD) in Adulthood
Risk Factors for Disability Pension among Young Adults Diagnosed with Attention-deficit Hyperactivity Disorder (ADHD) in Adulthood Open
Objective: To investigate risk factors of disability pension (DP) in young adults diagnosed with ADHD in Sweden. Method: In total, 9718 individuals diagnosed with incident ADHD in young adult age (19–29 years) 2006 to 2011, were identified…
View article: Sickness absence and disability pension among women with breast cancer: a population-based cohort study from Sweden
Sickness absence and disability pension among women with breast cancer: a population-based cohort study from Sweden Open
Background Women’s return to work after diagnosis of breast cancer (BC) is becoming more prevalent. However, register-based national investigation on sickness absence (SA) and disability pension (DP) in BC women is lacking. The aim of the …
View article: Overall and diagnosis-specific sickness absence and disability pension in colorectal cancer survivors and references in Sweden
Overall and diagnosis-specific sickness absence and disability pension in colorectal cancer survivors and references in Sweden Open
Purpose To longitudinally investigate overall and diagnosis-specific sickness absence (SA) and disability pension (DP) in colorectal cancer (CRC) survivors and references and to identify potential risk factors. Methods This longitudinal re…
View article: Tumor metabolism and neurocognition in CNS lymphoma
Tumor metabolism and neurocognition in CNS lymphoma Open
Background The mechanistic basis for neurocognitive deficits in central nervous system (CNS) lymphoma and other brain tumors is incompletely understood. We tested the hypothesis that tumor metabolism impairs neurotransmitter pathways and n…
View article: Trajectories of sickness absence and disability pension before and after colorectal cancer: A Swedish longitudinal population-based matched cohort study
Trajectories of sickness absence and disability pension before and after colorectal cancer: A Swedish longitudinal population-based matched cohort study Open
Objectives Working-aged colorectal cancer (CRC) patients have a much better survival, indicating the importance of their future work situation. We investigated trajectories of sickness absence and disability pension (SADP) days before and …
View article: Immunohistochemical Detection of Human Papillomavirus 16 E7 Oncoprotein in Cervical Lesions
Immunohistochemical Detection of Human Papillomavirus 16 E7 Oncoprotein in Cervical Lesions Open
Almost all cervical cancer is associated with persistent infection of high-risk (hr) human papillomavirus (HPV) like HPV16. The E7 oncoprotein encoded by hrHPV plays a crucial role in carcinogenesis. The present study aimed to establish a …
View article: HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry
HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry Open
Background: The persistent infection of high-risk human papillomavirus (HR-HPV) is one of the most common causes of cervical cancer worldwide, and HPV type 58 (HPV58) is the third most common HPV type in eastern Asia. The E7 oncoprotein is…