Lingjun Yan
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View article: Exposome-wide association study of environmental toxicants and periodontitis among United States adults
Exposome-wide association study of environmental toxicants and periodontitis among United States adults Open
This nationally representative exposome-wide investigation identified significant associations between multiple environmental toxicants and periodontitis, with inflammatory pathways partially mediating these relationships. These findings e…
View article: Is systemic inflammation a missing link between oral microbiome and oral squamous cell carcinoma? Results from multi-omics integration analyses
Is systemic inflammation a missing link between oral microbiome and oral squamous cell carcinoma? Results from multi-omics integration analyses Open
Our multi-omics integration suggests that systemic inflammation, particularly through IL-22 and CCL5 upregulation, serves as a mechanistic link between specific oral bacteria and OSCC risk, which could provide new strategies for OSCC preve…
View article: Exposure to organochlorine pesticides and mortality risk among individuals with diabetes: A prospective cohort analysis and network pharmacology study
Exposure to organochlorine pesticides and mortality risk among individuals with diabetes: A prospective cohort analysis and network pharmacology study Open
Emerging evidence suggests a potential link between organochlorine pesticides (OCPs) and diabetes, yet their impact on mortality risk among diabetic individuals is poorly understood. This longitudinal study assessed 1846 diabetic participa…
View article: Differences in perceived sensitivity to air pollution between smokers and non-smokers during a heavy haze episode in Northeast China
Differences in perceived sensitivity to air pollution between smokers and non-smokers during a heavy haze episode in Northeast China Open
View article: Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis
Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis Open
Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + ) recombinati…
View article: Comparison of key floral components between two <scp><i>Tilia</i></scp> species and among different processing technologies as revealed by widely targeted metabolomic profiling
Comparison of key floral components between two <span><i>Tilia</i></span> species and among different processing technologies as revealed by widely targeted metabolomic profiling Open
BACKGROUND Tilia has a long history of cultivation and holds high ornamental and economic value. The volatile aroma compounds of Tilia flowers have significant characteristics that contribute to their ornamental appeal, and affect the flav…
View article: Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study
Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study Open
Environmental pollutants have been implicated in various detrimental health effects. However, the specific relationship between environmental pollutant exposure and the risk of cerebrovascular disease mortality remains uncertain. This stud…
View article: Oral microbiome dysbiosis may be associated with intra cranial aneurysms
Oral microbiome dysbiosis may be associated with intra cranial aneurysms Open
View article: Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation
Association of multiple trace metals in scalp hair with glioma risk: the mediating role of inflammation Open
Objective To explore the relationship between 35 trace metals in scalp hair and the glioma risk as well as the potential mediating roles of 27 plasma inflammatory cytokines. Methods A case–control study involving 228 participants was perfo…
View article: The salivary microbiome and oral health status in HBeAg-negative chronic hepatitis B
The salivary microbiome and oral health status in HBeAg-negative chronic hepatitis B Open
View article: The effect of fear-avoidance intervention on kinesiophobia and self-efficacy in patients after percutaneous coronary intervention: study protocol for a clinical randomized controlled trial
The effect of fear-avoidance intervention on kinesiophobia and self-efficacy in patients after percutaneous coronary intervention: study protocol for a clinical randomized controlled trial Open
View article: Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy
Carrier‐Free Self‐Assembly Nano‐Sonosensitizers for Sonodynamic‐Amplified Cuproptosis‐Ferroptosis in Glioblastoma Therapy Open
Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy of copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with a short blood half‐life, face chal…
View article: Inflammation as a Mediator of Microbiome Dysbiosis-Associated DNA Methylation Changes in Gastric Premalignant Lesions
Inflammation as a Mediator of Microbiome Dysbiosis-Associated DNA Methylation Changes in Gastric Premalignant Lesions Open
View article: Effects of different brisk walking intensities on adherence and cardiorespiratory endurance of cardiac rehabilitation among patients with CHD after PCI: protocol for a randomised controlled trial
Effects of different brisk walking intensities on adherence and cardiorespiratory endurance of cardiac rehabilitation among patients with CHD after PCI: protocol for a randomised controlled trial Open
Introduction Cardiac rehabilitation (CR) is a critical treatment for patients with coronary heart disease after percutaneous coronary intervention. Unfortunately, participation and adherence of CR are unexpectedly poor. This study aims to …
View article: The complete chloroplast genome of<i>Tilia endochrysea</i>Handel-Mazzetti 1926 (Malvaceae)
The complete chloroplast genome of<i>Tilia endochrysea</i>Handel-Mazzetti 1926 (Malvaceae) Open
Tilia endochrysea Handel-Mazzetti 1926, distributed in the southern margin of Chinese Subtropical Zone, is the only one species in genus Tilia has dehiscent fruit. The whole chloroplast genome of T. endochrysea was 162…
View article: Knowledge of COVID-19 and its prevention among rural residents in Fuqing, China
Knowledge of COVID-19 and its prevention among rural residents in Fuqing, China Open
View article: Correction to: A composite oral hygiene score and the risk of oral cancer and its subtypes: a large‑scale propensity score‑based study
Correction to: A composite oral hygiene score and the risk of oral cancer and its subtypes: a large‑scale propensity score‑based study Open
View article: Identification of Suitable Reference Genes for qRT-PCR Normalization in Tilia miqueliana Maxim
Identification of Suitable Reference Genes for qRT-PCR Normalization in Tilia miqueliana Maxim Open
Quantitative real-time polymerase chain reaction (qRT-PCR) is a rapid and effective approach toward detecting the expression patterns of target genes. The selection of a stable reference gene under specific test condition is essential for …
View article: Association Between Rare Earth Element Cerium and the Risk of Oral Cancer: A Case-Control Study in Southeast China
Association Between Rare Earth Element Cerium and the Risk of Oral Cancer: A Case-Control Study in Southeast China Open
Cerium (Ce), the most abundant of rare earth elements in the earth's crust, has received much health concerns due to its wide application in industry, agriculture, and medicine. The current study aims to evaluate whether there is an associ…
View article: Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer
Prognostic value of transforming growth factor beta receptor 1 polymorphisms in patients with oral cancer Open
Objective To investigate possible associations between disease‐specific survival (DSS) of oral cancer and single nucleotide polymorphisms (SNPs) in transforming growth factor beta receptor 1 ( TGFBR1 ). Methods Using iPLEX Sequenom MassARR…
View article: A functional haplotype of <i>NFKB1</i> influence susceptibility to oral cancer: a population‐based and in vitro study
A functional haplotype of <i>NFKB1</i> influence susceptibility to oral cancer: a population‐based and in vitro study Open
Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cance…
View article: Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study Open
Background: Although previous studies have explored the associations of modifiable lifestyle factors with oral cancer risk, few studies integrated these factors and established predictive tools for oral cancer risk in different sexe…
View article: Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure
Differences in modifiable factors of oral squamous cell carcinoma in the upper and lower of oral fissure Open
The aim of this study was to explore differences in the effects of modifiable factors on oral squamous cell carcinoma (OSCC) occurring in the lower oral fissure (LOF) and upper oral fissure (UOF). We conducted a case-control study with 697…
View article: Dietary score and the risk of oral cancer: a case-control study in southeast China
Dietary score and the risk of oral cancer: a case-control study in southeast China Open
This study aims to develop a simple dietary score to comprehensively evaluate the role of diet in the risk of oral cancer. A case-control study including 930 oral cancer cases and 2667 frequency-matched controls was performed in Fujian, Ch…
View article: Independent and joint effects of tea and milk consumption on oral cancer among non-smokers and non-drinkers: a case-control study in China
Independent and joint effects of tea and milk consumption on oral cancer among non-smokers and non-drinkers: a case-control study in China Open
This study aims to evaluate the independent and joint effects of tea and milk consumption on oral cancer risk among non-smokers and non-drinkers (NS/ND). A hospital-based case-control study was performed in Fujian, China. 421 cases and fre…
View article: Novel polymorphism in <i>FADS1</i> gene and fish consumption on risk of oral cancer: A case-control study in southeast China
Novel polymorphism in <i>FADS1</i> gene and fish consumption on risk of oral cancer: A case-control study in southeast China Open
The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral ca…
View article: A novel prognostic index for oral squamous cell carcinoma patients with surgically treated
A novel prognostic index for oral squamous cell carcinoma patients with surgically treated Open
This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fuj…
View article: Prospective study on factors affecting the prognosis of oral cancer in a Chinese population
Prospective study on factors affecting the prognosis of oral cancer in a Chinese population Open
This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collecte…
View article: Passive smoking and cooking oil fumes (COF) may modify the association between tea consumption and oral cancer in Chinese women
Passive smoking and cooking oil fumes (COF) may modify the association between tea consumption and oral cancer in Chinese women Open