Lingkai Zhang
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View article: StOSD1/UVI4 is crucial for accurate mitotic progression and the maintenance of leaf morphology in potato
StOSD1/UVI4 is crucial for accurate mitotic progression and the maintenance of leaf morphology in potato Open
Background Accurate cell cycle progression is essential for plant growth and development. UVI4(UV-B-insensitive 4) and its homologue OSD1(Omission of the Second Division) function as negative regulators of the anaphase-promoting complex/cy…
View article: Recent Advances in HPV Detection: From Traditional Methods to Nanotechnology and the Application of Quantum Dots
Recent Advances in HPV Detection: From Traditional Methods to Nanotechnology and the Application of Quantum Dots Open
Cervical cancer, a significant public health concern, demands precise and expeditious detection methods to curb the spread of human papillomavirus (HPV). The early detection of cervical cancer remains a critical challenge in developing rel…
View article: Uncovering Changes in <scp>3D</scp> ‐Chromatin Structure and Dynamic Gene Expression During Spermatogenesis
Uncovering Changes in <span>3D</span> ‐Chromatin Structure and Dynamic Gene Expression During Spermatogenesis Open
Spermatogonial stem cells (SSCs) have the potential for self‐renewal and differentiation, and normal spermatogenesis maintains a stable number of spermatogonial stem cells and spermatozoa. Spermatogenesis is accompanied by changes in the t…
View article: <i>TERT</i> promoter mutations or protein overexpression define an aggressive subset with favourable immunotherapeutic response in advanced urothelial carcinoma
<i>TERT</i> promoter mutations or protein overexpression define an aggressive subset with favourable immunotherapeutic response in advanced urothelial carcinoma Open
Objective Telomerase reverse transcriptase ( TERT ) gene promoter mutation (TPM) is a key non-coding somatic alteration in urothelial carcinoma (UC) that plays a critical role in telomerase activation. Despite its importance, the prognosti…
View article: Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression
Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression Open
Background The E3 ubiquitin ligase murine double minute 2 (MDM2) binds the p53 transcriptional activation domain and acts as a potent inhibitor of TP53 pathway, one of the three most crucial oncogenic pathways in urothelial carcinoma (UC).…
View article: Microwave ablation is superior to radiofrequency ablation in the treatment of hepatocellular carcinoma below 5 cm - A systematic review and meta-analysis
Microwave ablation is superior to radiofrequency ablation in the treatment of hepatocellular carcinoma below 5 cm - A systematic review and meta-analysis Open
The purpose of this study was to systematically evaluate the prognosis of patients with hepatocellular carcinoma (HCC) smaller than 5 cm using microwave ablation (MWA) versus radiofrequency ablation (RFA). PubMed, Cochrane Library and Emba…
View article: CircADAMTS16 Inhibits Differentiation and Promotes Proliferation of Bovine Adipocytes by Targeting miR-10167-3p
CircADAMTS16 Inhibits Differentiation and Promotes Proliferation of Bovine Adipocytes by Targeting miR-10167-3p Open
Circular RNAs (CircRNAs) are covalently closed-loop non-coding RNA (ncRNA) molecules present in eukaryotes. Numerous studies have demonstrated that circRNAs are important regulators of bovine fat deposition, but their precise mechanisms re…
View article: Genome-Wide Identification and Characterization of Bovine Fibroblast Growth Factor (FGF) Gene and Its Expression during Adipocyte Differentiation
Genome-Wide Identification and Characterization of Bovine Fibroblast Growth Factor (FGF) Gene and Its Expression during Adipocyte Differentiation Open
Fibroblast growth factor (FGF) family genes are a class of polypeptide factors with similar structures that play an important role in regulating cell proliferation and differentiation, nutritional metabolism, and neural activity. In previo…
View article: Development of Multiomics<i>in situ</i>Pairwise Sequencing (MiP-Seq) for Single-cell Resolution Multidimensional Spatial Omics
Development of Multiomics<i>in situ</i>Pairwise Sequencing (MiP-Seq) for Single-cell Resolution Multidimensional Spatial Omics Open
Delineating the spatial multiomics landscape will pave the way to understanding the molecular basis of physiology and pathology. However, current spatial omics technology development is still in its infancy. Here, we developed a high-throu…
View article: No-touch versus conventional radiofrequency ablation prognosis for hepatocellular carcinoma below 5cm: a systematic review and meta-analysis
No-touch versus conventional radiofrequency ablation prognosis for hepatocellular carcinoma below 5cm: a systematic review and meta-analysis Open
Review question
View article: Transcriptome-Wide Dynamics of m<b>6</b>A mRNA Methylation During Porcine Spermatogenesis
Transcriptome-Wide Dynamics of m<b>6</b>A mRNA Methylation During Porcine Spermatogenesis Open
Spermatogenesis is a continual process that occurs in the testes, in which diploid spermatogonial stem cells (SSCs) differentiate and generate haploid spermatozoa. This highly efficient and intricate process is orchestrated at multiple lev…
View article: Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation
Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation Open
Spermatogonial stem cells (SSCs) are able to undergo self-renewal and differentiation. Unlike the self-renewal that replenishes the SSC and progenitor pool, the differentiation is an irreversible process committed to meiosis. While the pre…
View article: Response of Soil Respiration and Its Components to Precipitation Exclusion in Vitex negundo Var. Heterophylla Shrubland of the Middle Taihang Mountain in North China
Response of Soil Respiration and Its Components to Precipitation Exclusion in Vitex negundo Var. Heterophylla Shrubland of the Middle Taihang Mountain in North China Open
Assessing the response of soil heterotrophic and autotrophic respiration to climate change is critical for forecasting terrestrial carbon cycle behavior in the future. In the present study, we conducted a drought experiment in Vitexnegundo…
View article: Additional file 2 of Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis
Additional file 2 of Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis Open
Additional file 2 supplementary Table2. The expression of the genes involved in spermatogonia proliferation and differentiation in spermatogonia subsets
View article: Additional file 1 of Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis
Additional file 1 of Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis Open
Additional file 1 supplementary Table1. List of data summary and the number of cells in each cluster.
View article: Stage‐specific embryonic antigen 4 is a membrane marker for enrichment of porcine spermatogonial stem cells
Stage‐specific embryonic antigen 4 is a membrane marker for enrichment of porcine spermatogonial stem cells Open
Background Spermatogonial stem cells (SSCs), as tissue‐specific stem cells, are capable of both self‐renewal and differentiation and supporting the continual and robust spermatogenesis for male fertility. As a rare sub‐fraction of undiffer…
View article: Establishing a Eukaryotic Pichia pastoris Cell-Free Protein Synthesis System
Establishing a Eukaryotic Pichia pastoris Cell-Free Protein Synthesis System Open
In recent years, cell-free protein synthesis (CFPS) systems have been used to synthesize proteins, prototype genetic elements, manufacture chemicals, and diagnose diseases. These exciting, novel applications lead to a new wave of interest …
View article: MicroRNA-382 inhibits the proliferation of mouse spermatogoniaby targeting Kmt5a
MicroRNA-382 inhibits the proliferation of mouse spermatogoniaby targeting Kmt5a Open
Spermatogenesis is a highly efficient and intricate process in the testis by which mature spermatozoa are produced daily to maintain lifelong male fertility. Essential to this process are spermatogonia capable of both proliferation and dif…
View article: Secreted Expression of the Cap Gene of Porcine Circovirus Type 2 in Classical Swine Fever Virus C-Strain: Potential of C-Strain Used as a Vaccine Vector
Secreted Expression of the Cap Gene of Porcine Circovirus Type 2 in Classical Swine Fever Virus C-Strain: Potential of C-Strain Used as a Vaccine Vector Open
Bivalent vaccines based on live attenuated viruses expressing a heterologous protein are an attractive strategy to address co-infections with various pathogens in the field. Considering the excellent efficacy and safety of the lapinized li…
View article: Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway
Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway Open
Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons (IFNs) and IFN-stimulated genes (ISGs) play a key role in host antiviral defense…
View article: Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnostic and Molecular Virology
Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnostic and Molecular Virology Open
Commonly used tests based on wild-type viruses, such as immunostaining, cannot meet the demands for rapid detection of viral replication, high-throughput screening for antivirals, as well as for tracking viral proteins or virus transport i…