Lingli Han
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View article: H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases
H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases Open
Background Monocytes have been confirmed to increase in persistently food-allergic children. A phenomenon of innate immune memory, called trained immunity, has also been observed in monocytes from allergic children. However, the underlying…
View article: Activated phosphoinositide 3‐kinase delta syndrome: Pathogenesis, clinical manifestations, and treatment
Activated phosphoinositide 3‐kinase delta syndrome: Pathogenesis, clinical manifestations, and treatment Open
Activated phosphoinositide 3‐kinase delta syndrome (APDS) is an autosomal dominant inborn errors of immunity resulting from gain of function mutations in the PIK3CD gene or loss of function mutations in the PIK3R1 gene. These mutations lea…
View article: CARD11 regulates the thymic Treg development in an NF-κB-independent manner
CARD11 regulates the thymic Treg development in an NF-κB-independent manner Open
Introduction CARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB activation downstream of the antigen receptor signal pathway. Defective CARD11 function results in abnormal development and differentiation of lymphoc…
View article: mTOR inhibition alleviates CD8+ T-cell senescence in activated phosphoinositide 3-kinase δ syndrome 2 patients
mTOR inhibition alleviates CD8+ T-cell senescence in activated phosphoinositide 3-kinase δ syndrome 2 patients Open
Background We investigated the clinical and immunological features in a Chinese cohort of activated phosphatidylinositol 3-kinase δ syndrome 2 (APDS2) and assessed the efficacy of Rapamycin therapy and the underlying mechanism. Results The…
View article: Design and Practice of Blended Teaching Mode Based on Rain Classroom in “Security System Engineering”
Design and Practice of Blended Teaching Mode Based on Rain Classroom in “Security System Engineering” Open
With the development of Internet + and the popularization of smart phones, there are more and more channels for students to acquire knowledge, and the traditional teaching mode can no longer meet the existing teaching needs.Based on this, …
View article: Exploration on the Reform of Ideological and Political Education in Engineering Mechanics
Exploration on the Reform of Ideological and Political Education in Engineering Mechanics Open
In the new era of education background, the party and the state put forward the ideological and political education concept of curriculum.Curriculum ideological and political education is to integrate ideological and political education in…
View article: Teaching Design of Integrating Ideological and Political Elements into “Safety System Engineering”
Teaching Design of Integrating Ideological and Political Elements into “Safety System Engineering” Open
This paper introduces the ideological and political teaching design of "security system engineering", in the use of modern teaching methods in class, before class, after class in the three teaching links of ideological elements, according …
View article: Research on Teaching Reform of Local Universities Based on Online Education
Research on Teaching Reform of Local Universities Based on Online Education Open
The rapid development of online education has set off a new upsurge of education and teaching reform in China.Online education makes educators think about how to deal with educational development problems under the Internet environment.At …
View article: The Prevalence of Fear of Childbirth and Its Association With Intolerance of Uncertainty and Coping Styles Among Pregnant Chinese Women During the COVID-19 Pandemic
The Prevalence of Fear of Childbirth and Its Association With Intolerance of Uncertainty and Coping Styles Among Pregnant Chinese Women During the COVID-19 Pandemic Open
Background Fear of childbirth (FOC) is one of the most common psychological symptoms among pregnant women and significantly relates to cesarean section, anxiety, and depression. However, it is not clear the prevalence and risk factors of F…
View article: Between Personality Traits and Postpartum Depression: The Mediated Role of Maternal Self-Efficacy
Between Personality Traits and Postpartum Depression: The Mediated Role of Maternal Self-Efficacy Open
Lingli Han,1 Ji Zhang,2 Jingxuan Yang,1 Xiaoyu Yang,1 Hua Bai1 1The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Zhengzhou Maternal and Child Health Hospital, Zhengzhou, Henan, People’s Re…
View article: Study on Monitoring and Acquisition System of Stress throughout the Life Cycle of Vehicle
Study on Monitoring and Acquisition System of Stress throughout the Life Cycle of Vehicle Open
It is complex that the structure and operating environment of Vehicle.Using stress monitoring and acquisition system, we can collect temperature and humidity, load, vibration and other information in the whole life cycle of vehicle.The sys…
View article: The Enhancement Arithmetic of BP Neural Network Based on Target Optimizing
The Enhancement Arithmetic of BP Neural Network Based on Target Optimizing Open
BP neural network recognition algorithm was used to carry through target recognition, then we adopted quadratic programming and generalized least squares to optimize the network weights and thresholds, at last the algorithm formula was ded…