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View article: Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer
Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer Open
Epigenetics is an emerging mechanism for tumorigenesis. Treatment that targets epigenetic regulators is becoming an attractive strategy for cancer therapy. The role of epigenetic therapy in prostate cancer (PCa) remains elusive. Previously…
View article: ZFAND5 Is an Independent Prognostic Biomarker of Perihilar Cholangiocarcinoma
ZFAND5 Is an Independent Prognostic Biomarker of Perihilar Cholangiocarcinoma Open
Background Cholangiocarcinoma (CCA) is a highly aggressive malignancy with extremely poor prognosis. Perihilar CCA (pCCA) is the most common subtype of CCA, but its biomarker study is much more lagged behind other subtypes. ZFAND5 protein …
View article: Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity Open
The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails ext…
View article: Therapeutic Targeting of Histone Lysine Demethylase KDM4B Blocks the Growth of Castration-Resistant Prostate Cancer
Therapeutic Targeting of Histone Lysine Demethylase KDM4B Blocks the Growth of Castration-Resistant Prostate Cancer Open
Background: Accumulating evidence points to epigenetic mechanisms as essential in tumorigenesis. Treatment that targets epigenetic regulators is becoming an attractive strategy for cancer therapy. The role of epigenetic therapy in prostate…
View article: Therapeutic Targeting of Histone Lysine Demethylase KDM4B Blocks the Growth of Castration-resistant Prostate Cancer
Therapeutic Targeting of Histone Lysine Demethylase KDM4B Blocks the Growth of Castration-resistant Prostate Cancer Open
Background: Accumulating evidence points to epigenetic mechanisms as essential in tumorigenesis. Treatment that targets epigenetic regulators is becoming an attractive strategy for cancer therapy. The role of epigenetic therapy in prostate…
View article: Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity Open
The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails dra…
View article: PD-1 expression on uveal melanoma induces tumor proliferation and predicts poor patient survival
PD-1 expression on uveal melanoma induces tumor proliferation and predicts poor patient survival Open
Introduction: Uveal melanoma is one of the most common primary intraocular malignant tumors with poor prognosis and limited treatments. Programmed cell death receptor-1 (PD-1) blockade represents the primary treatment strategy of immune ch…
View article: Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation Open
Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an important role in progression of castration-resistant pro…
View article: ANALYTICAL STUDY OF THE TEO-DIMENSIONAL TIME-FRTACTIONAL NAVIER-STOKES EQUATIONS
ANALYTICAL STUDY OF THE TEO-DIMENSIONAL TIME-FRTACTIONAL NAVIER-STOKES EQUATIONS Open
In this paper, the two-dimensional (2D) Holf-Cole transformation with mass conservation in the frame of conformable derivative is developed, and then by introducing some exact solutions that satisfy linear differential equations and using …
View article: High Mobility Group Box 1 (HMGB1) Predicts Invasion and Poor Prognosis of Glioblastoma Multiforme via Activating AKT Signaling in an Autocrine Pathway
High Mobility Group Box 1 (HMGB1) Predicts Invasion and Poor Prognosis of Glioblastoma Multiforme via Activating AKT Signaling in an Autocrine Pathway Open
BACKGROUND As a nuclear protein and a secreted protein, HMGB1 is involved in many cellular processes such as proliferation, transcription, and inflammation. The overexpression of HMGB1 in various types of cancers is reported, but its clini…
View article: Fotemustine, teniposide and dexamethasone versus high-dose methotrexate plus cytarabine in newly diagnosed primary CNS lymphoma: a randomised phase 2 trial
Fotemustine, teniposide and dexamethasone versus high-dose methotrexate plus cytarabine in newly diagnosed primary CNS lymphoma: a randomised phase 2 trial Open
View article: Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction Open
Detection of MMP-9 and TIMP-1 expression allows stratification of AEG patients into different survival categories and can be useful for precise individual evaluation and survival prediction.
View article: Expression of G protein-coupled receptor 56 is associated with tumor progression in non-small-cell lung carcinoma patients
Expression of G protein-coupled receptor 56 is associated with tumor progression in non-small-cell lung carcinoma patients Open
GPR56 plays an important role in tumor development and may serve as a promising target for prognostic prediction in NSCLC.
View article: KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes
KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes Open