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View article: Time-series transcriptomics and alternative splicing analysis of embryonic development of the asian honeybee (Apis cerana)
Time-series transcriptomics and alternative splicing analysis of embryonic development of the asian honeybee (Apis cerana) Open
Embryonic development in honeybees is a critical stage that shapes the formation of organs and structures in adult bees. Although there has been substantial progress in transcriptome studies on honeybee embryogenesis, time-series transcrip…
View article: Soluble <scp>Sema4D</scp> From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/<scp>mTOR</scp> Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws
Soluble <span>Sema4D</span> From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/<span>mTOR</span> Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws Open
Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient. Gamma delta (γδ) T cells pre…
View article: Dihydroartemisinin targets the miR-497-5p/SOX5 axis to suppress tumor progression in non-small cell lung cancer
Dihydroartemisinin targets the miR-497-5p/SOX5 axis to suppress tumor progression in non-small cell lung cancer Open
Introduction Non-small cell lung cancer (NSCLC) remains a lethal malignancy with limited therapeutic options. Although dihydroartemisinin (DHA) exhibits anticancer properties, its mechanisms in NSCLC are incompletely understood. This study…
View article: Association between prenatal exposure to per- and polyfluoroalkyl substances and blood pressure among preschool-aged children: The moderating effect of child-age and the mediating effect of inflammatory cytokine
Association between prenatal exposure to per- and polyfluoroalkyl substances and blood pressure among preschool-aged children: The moderating effect of child-age and the mediating effect of inflammatory cytokine Open
Our aim is to evaluate the association of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with offspring blood pressure (BP); examine the moderating effect of children's age; and the mediating effects of inflammatory cytoki…
View article: The role of fibroblast-neutrophil crosstalk in the pathogenesis of inflammatory diseases: a multi-tissue perspective
The role of fibroblast-neutrophil crosstalk in the pathogenesis of inflammatory diseases: a multi-tissue perspective Open
Neutrophil-fibroblast crosstalk drives inflammatory pathology across organ systems through both shared and tissue-specific mechanisms. This review synthesizes evidence from skin, lung, gut, cardiovascular, joint, sinus, and oral diseases, …
View article: Hypoxia-Induced VGF Promotes Cell Migration and Invasion in Prostate Cancer via the PI3K/Akt Axis
Hypoxia-Induced VGF Promotes Cell Migration and Invasion in Prostate Cancer via the PI3K/Akt Axis Open
Background: Metastasis is a major cause of prostate cancer (PCa)-related deaths in men. Recent studies have indicated that VGF nerve growth factor inducible (VGF) affects tumor invasion and metastasis. The present study investigated whethe…
View article: Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells
Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells Open
Small extracellular vesicles (sEVs) are nanosized vesicles. Death receptor 5 (DR5) mediates extrinsic apoptosis. We engineer DR5 agonistic single-chain variable fragment (scFv) expression on the surface of sEVs derived from natural killer …
View article: Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models
Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models Open
With the development of immunotherapy, there is an ongoing need to develop models that can recapitulate the tumor microenvironment of native tumors. While traditional two- and three-dimensional models can offer insights into cancer develop…
View article: Editorial: Regulation of tumor immune surveillance: drug discovery and mechanisms
Editorial: Regulation of tumor immune surveillance: drug discovery and mechanisms Open
EDITORIAL article Front. Immunol., 05 January 2024Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1352864
View article: Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN [Retraction]
Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN [Retraction] Open
[This retracts the article DOI: 10.2147/IJN.S257084.].
View article: Patient-derived melanoma organoid models facilitate the assessment of immunotherapies
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies Open
This work was supported by the NIH grants CA114046, CA261608, CA258113, and the Tara Miller Melanoma Foundation.
View article: The construction and analysis of tricarboxylic acid cycle related prognostic model for cervical cancer
The construction and analysis of tricarboxylic acid cycle related prognostic model for cervical cancer Open
Introduction: Cervical cancer (CC) is the fourth most common malignant tumor in term of in incidence and mortality among women worldwide. The tricarboxylic acid (TCA) cycle is an important hub of energy metabolism, networking one-carbon me…
View article: Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4: Erratum
Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4: Erratum Open
[This corrects the article DOI: 10.7150/thno.34676.].
View article: Preclinical platforms to study therapeutic efficacy of human γδ T cells
Preclinical platforms to study therapeutic efficacy of human γδ T cells Open
Background Gamma delta (γδ) T lymphocytes are promising candidate for adoptive T cell therapy, however, their treatment efficacy is not satisfactory. Vδ2 T cells are unique to primates and few suitable models are available to assay their a…
View article: Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function
Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function Open
Background Gamma delta (γδ) T cells are attractive effector cells for cancer immunotherapy. Vδ2 T cells expanded by zoledronic acid (ZOL) are the most commonly used γδ T cells for adoptive cell therapy. However, adoptive transfer of the ex…
View article: Dichotomous and stable gamma delta T-cell number and function in healthy individuals
Dichotomous and stable gamma delta T-cell number and function in healthy individuals Open
Background Gamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, adoptive immunotherapy with γδT cells has exhibited mixed treatment responses. B…
View article: Targeting regulatory T cells for immunotherapy in melanoma
Targeting regulatory T cells for immunotherapy in melanoma Open
Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a key to immune suppressive microenvironment in solid tumors. Many studies have revealed the biology of Tregs in various human pathologies. Here we …
View article: Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors Open
The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effects caused by NMs have been ob…
View article: Small extracellular vesicles‐based cell‐free strategies for therapy
Small extracellular vesicles‐based cell‐free strategies for therapy Open
Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellular messenger regulating recipient cell…
View article: <p>Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN</p>
Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN Open
This study indicates the potential of functionalized GO-PEI as a vehicle for miRNA inhibitor delivery to treat osteosarcoma with low toxicity and miR-214 can be a good target for osteosarcoma therapy.
View article: <p>Efficient miRNA Inhibitor Delivery with Graphene Oxide-Polyethylenimine to Inhibit Oral Squamous Cell Carcinoma</p>
Efficient miRNA Inhibitor Delivery with Graphene Oxide-Polyethylenimine to Inhibit Oral Squamous Cell Carcinoma Open
This study indicates that functionalized GO-PEI with low toxicity has promising potential for miRNA delivery for the treatment of OSCC.
View article: Toxicity of Zirconia oxide Nanoparticles: Liver Biodistribution and Liver Damages
Toxicity of Zirconia oxide Nanoparticles: Liver Biodistribution and Liver Damages Open
Background: Zirconia nanoparticles (ZrO2-NPs) have been increasingly used in industrial, biomedical and dental materials. However, the scientific basis for the toxicological effects of ZrO2-NPs is poorly elucidated, and the understanding o…
View article: Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance
Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance Open
Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, the underlying molecular mechanisms are poorly understood. Increased sialyltransfera…
View article: A microRNA‑24‑to‑secretagogin regulatory pathway mediates cholesterol‑induced inhibition of insulin secretion
A microRNA‑24‑to‑secretagogin regulatory pathway mediates cholesterol‑induced inhibition of insulin secretion Open
Hypercholesterolemia is a key factor leading to β‑cell dysfunction, but its underlying mechanisms remain unclear. Secretagogin (Scgn), a Ca2+ sensor protein that is expressed at high levels in the islets, has been shown to play a key role …
View article: Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4
Functionalization of SF/HAP Scaffold with GO-PEI-miRNA inhibitor Complexes to Enhance Bone Regeneration through Activating Transcription Factor 4 Open
Evidence indicates that microRNAs (miRNAs) play vital roles in regulating osteogenic differentiation and bone formation. Methods: Here, we show that a polyethyleneimine (PEI)-functionalized graphene oxide (GO) complex efficiently loaded wi…
View article: The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis
The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis Open
Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to the potential unexpected toxic effects of GBMs. Here, we review the recent literature regarding the impact of G…
View article: Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms Open
Due to their unique physicochemical properties, graphene-family nanomaterials (GFNs) are widely used in many fields, especially in biomedical applications. Currently, many studies have investigated the biocompatibility and toxicity of GFNs…