Lingling Wu
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View article: The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis
The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis Open
Introduction Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), which involves various epigenetic modifications. Objectives N 6 ‐methyladenosine (m 6 A), the most prevalent RNA modification in eukaryotic…
View article: A high heat dissipation strategy based on a multi-scale porous hydrogel and heat sink exhibiting cooling capacity comparable to that of forced air convection but with zero energy consumption
A high heat dissipation strategy based on a multi-scale porous hydrogel and heat sink exhibiting cooling capacity comparable to that of forced air convection but with zero energy consumption Open
A new composite heat sink (CHS) is designed based on a multi-scale porous hydrogel. Owing to the high heat transfer coefficient and zero energy consumption property, the CHS shows great potential in electronic device cooling field.
View article: Functional targeted therapy for glioma based on platelet membrane-coated nanogels
Functional targeted therapy for glioma based on platelet membrane-coated nanogels Open
Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells …
View article: Accuracy of Ultrasound Diagnosis of Thyroid Nodules Based on Artificial Intelligence-Assisted Diagnostic Technology: A Systematic Review and Meta-Analysis
Accuracy of Ultrasound Diagnosis of Thyroid Nodules Based on Artificial Intelligence-Assisted Diagnostic Technology: A Systematic Review and Meta-Analysis Open
Background. Ultrasonography (US) is the most common method of identifying thyroid nodules, but US images require an experienced surgeon for identification. Many artificial intelligence (AI) techniques such as computer-aided diagnostic syst…
View article: Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma Open
These results provide a new strategy of utilizing PCNPs as carriers for drug delivery, which improves the targeting efficiency and therapeutic efficacy of chemotherapeutic agents for glioma therapy.
View article: Platelet–Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
Platelet–Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma Open
Cell membrane-camouflaged nanoparticles are drawing increasing attention because their surfaces retain the natural functionalities of the cell plasma membranes, making them a unique class of biomimetic materials combining natural and synth…
View article: <p>Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition</p>
Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition Open
Kaiqiang Li,1&ndash; 3,* Lingling Wu,1,* Yili Chen,4,* Yuanyuan Li,5 Qianni Wang,1 Min Li,3 Ke Hao,2,3 Wei Zhang,3 Shanshan Jiang,2 Zhen Wang1,2 1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 3250…
View article: C21 Fraction Refined from <i>Marsdenia tenacissima-</i>Induced Apoptosis is Enhanced by Suppression of Autophagy in Human Gastric Cell Lines
C21 Fraction Refined from <i>Marsdenia tenacissima-</i>Induced Apoptosis is Enhanced by Suppression of Autophagy in Human Gastric Cell Lines Open
C21 steroidal glycosides have been extensively reported for treating several types of cancer and are widely found in Marsdenia tenacissima. In this study, a C21 fraction was synthesized from M. tenacissima, and its anti-cancer potency was …
View article: Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe
Rapid differentiation between bacterial infections and cancer using a near-infrared fluorogenic probe Open
A new nitroreductase-responsive near-infrared fluorogenic probe can specifically image live bacteria in mouse models and does not accumulate at sites of inflammation or tumor.
View article: Chronic active EBV infection associated with NK cell lymphoma and hemophagocytic lymphohistiocytosis in a 27-year-old woman
Chronic active EBV infection associated with NK cell lymphoma and hemophagocytic lymphohistiocytosis in a 27-year-old woman Open
Rationale: Chronic active Epstein-Barr virus infection (CAEBV) is a common infectious disease that often affects multiple organs or systems. However, it is liable to be neglected and misdiagnosed owing to its insidious onset, lack of speci…