Lingmei Kong
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View article: Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects
Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects Open
The human deubiquitinating enzyme ubiquitin-specific peptidase 7 (USP7) has emerged as a promising anti-tumor target, particularly in colorectal cancer, due to its regulation of the MDM2/p53 axis. Through a combination of ubiquitin C-termi…
View article: Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells
Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells Open
Hematological malignancies, such as leukemia and multiple myeloma, are heterogeneous blood diseases that affect blood, lymphoid and other related tissues. Ciclopirox olamine (CPX), which is an antifungal agent, was identified as a promisin…
View article: Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives Open
View article: Application of Diffusional Kurtosis Imaging on Normal-Appearing White Matter in Cerebral Small Vessel Disease
Application of Diffusional Kurtosis Imaging on Normal-Appearing White Matter in Cerebral Small Vessel Disease Open
Background: This study aimed to investigate the diagnostic potential of diffusional kurtosis imaging (DKI) parameters in detecting pathological alterations in the normal-appearing white matter (NAWM) associated with cerebral small vessel d…
View article: Asini Corii Colla (Ejiao) as a health-care food and traditional Chinese medicine: A review of its chemical composition, pharmacological activity, quality control, modern applications
Asini Corii Colla (Ejiao) as a health-care food and traditional Chinese medicine: A review of its chemical composition, pharmacological activity, quality control, modern applications Open
Asini Corii Colla (Ejiao) is recognized as an excellent source that bridges both medicinal and nutritional benefits. It is rich in protein, polypeptides, amino acids, fatty acids, polysaccharides, and other components. It offers a range of…
View article: Thiostrepton as a Potential Therapeutic Agent for Hepatocellular Carcinoma
Thiostrepton as a Potential Therapeutic Agent for Hepatocellular Carcinoma Open
Due to limited drug efficacy and drug resistance, it is urgent to explore effective anti-liver cancer drugs. Repurposing drugs is an efficient strategy, with advantages including reduced costs, shortened development cycles, and assured saf…
View article: Magnetic Resonance Study on Restoration of the Glymphatic System and Brain Network in Insomnia Patients with TCM Physiotherapy: A Case Report
Magnetic Resonance Study on Restoration of the Glymphatic System and Brain Network in Insomnia Patients with TCM Physiotherapy: A Case Report Open
Impairment in the cerebral glymphatic system may be one of the primary etiologic reasons for insomnia. Traditional Chinese medicine (TCM) physiotherapy is helpful for treating insomnia patients, with few side effects; however, its influenc…
View article: Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin Open
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most freq…
View article: β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K Open
View article: Alterations of White Matter Structural Brain Network in Children with Sensorineural Hearing Loss：A Graph Theory Analysis
Alterations of White Matter Structural Brain Network in Children with Sensorineural Hearing Loss：A Graph Theory Analysis Open
View article: Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles
Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles Open
Three series of podophyllotoxin derivatives with various nitrogen-containing heterocycles were designed and synthesized. The antitumor activity of these podophyllotoxin derivatives was evaluated in vitro against a panel of human tumor cell…
View article: Neurochemical and microstructural alterations in bipolar and depressive disorders: A multimodal magnetic resonance imaging study
Neurochemical and microstructural alterations in bipolar and depressive disorders: A multimodal magnetic resonance imaging study Open
Aims Depression in bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatments and poor clinical outcomes in many bipolar patients. Herein, we report direct comparisons between medication-free patients…
View article: Protective Effects of Resveratrol on Brain Edema and Microstructural Changes in Human Brain After Acute Alcohol Intake: Assessment by Diffusion Weighted Kurtosis Imaging
Protective Effects of Resveratrol on Brain Edema and Microstructural Changes in Human Brain After Acute Alcohol Intake: Assessment by Diffusion Weighted Kurtosis Imaging Open
Resveratrol can initiate anti-alcoholic functions in the human body. Magnetic resonance diffusion kurtosis imaging (DKI) can comprehensively evaluate ethanol associated brain changes at different time points. This study aimed at utilizing …
View article: Analysis on topological alterations of functional brain networks after acute alcohol intake using resting-state functional magnetic resonance imaging and graph theory
Analysis on topological alterations of functional brain networks after acute alcohol intake using resting-state functional magnetic resonance imaging and graph theory Open
Aims Alcohol consumption could lead to a series of health problems and social issues. In the current study, we investigated the resting-state functional brain networks of healthy volunteers before and after drinking through graph-theory an…
View article: Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities
Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities Open
Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Ph…
View article: Antimicrobial Peptide Brevinin-1RL1 from Frog Skin Secretion Induces Apoptosis and Necrosis of Tumor Cells
Antimicrobial Peptide Brevinin-1RL1 from Frog Skin Secretion Induces Apoptosis and Necrosis of Tumor Cells Open
Cancer has always been one of the most common malignant diseases in the world. Therefore, there is an urgent need to find potent agents with selective antitumor activity against cancer cells. It has been reported that antimicrobial peptide…
View article: Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth Open
View article: Oceanic Eddy Identification Using an AI Scheme
Oceanic Eddy Identification Using an AI Scheme Open
Oceanic eddies play an important role in global energy and material transport, and contribute greatly to nutrient and phytoplankton distribution. Deep learning is employed to identify oceanic eddies from sea surface height anomalies data. …
View article: Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin Open
View article: Physalis peruviana-Derived 4β-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo
Physalis peruviana-Derived 4β-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo Open
Deregulation of the Wnt signaling pathway leads to colorectal cancer progression. Natural dietary compounds serve as promising candidates for development as chemopreventive agents by suppressing the Wnt/β-catenin signaling pathway. Physali…
View article: Effects of Acute Alcohol Consumption on the Human Brain: Diffusional Kurtosis Imaging and Arterial Spin-Labeling Study
Effects of Acute Alcohol Consumption on the Human Brain: Diffusional Kurtosis Imaging and Arterial Spin-Labeling Study Open
Physiologic and microstructural alterations in the brain on alcohol consumption were examined. Brain areas with blood flow alteration detected by 3D arterial spin-labeling were highly consistent with susceptible areas detected by diffusion…
View article: B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells Open
Cancer stem cells (CSCs) have been implicated in metastasis, relapse, and therapeutic resistance of cancer, so successful cancer therapy may therefore require the development of drugs against CSCs or combining anti-CSCs drugs with conventi…
View article: Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer Open
Tumor protein D52 (TPD52) is an oncogene amplified and overexpressed in various cancers. Tumor-suppressive microRNA-449a and microRNA-34a (miR-449a/34a) were recently reported to inhibit breast cancer cell migration and invasion via target…
View article: Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model Open
Star-PAP is a noncanonical poly(A) polymerase and required for the expression of a select set of mRNAs. However, the pathological role of Star-PAP in cancer largely remains unknown. In this study, we observed decreased expression of Star-P…
View article: Diffusion Kurtosis Imaging Detects Microstructural Changes in the Brain after Acute Alcohol Intoxication in Rats
Diffusion Kurtosis Imaging Detects Microstructural Changes in the Brain after Acute Alcohol Intoxication in Rats Open
The aim of this study was to test the technical feasibility of diffusion kurtosis imaging (DKI) in the brain after acute alcohol intoxication. Diffusion tensor imaging (DTI) and DKI during 7.0 T MRI were performed in the frontal lobe and t…
View article: Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK Open
View article: Four New Minor Compounds from Seeds <i>of Plantago asiatica</i>
Four New Minor Compounds from Seeds <i>of Plantago asiatica</i> Open
Four new compounds, a dibenzylbutane lignin, plasiaticine F (1), an acetylenic glycoside, plasiaticine G (2), an indole alkaloid, plasiaticine H (3), and an ionone derivative, plasiaticine I (4), were isolated from the seeds of Plantago as…
View article: N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells Open
We found for the first time that NHPI displayed antitumor activity which is associated with the inhibition of mTOR signaling pathway. Our findings suggest that NHPI may be developed as a promising candidate for cancer therapeutics by targe…
View article: Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell <i>in vitro</i> and <i>in vivo</i> targeting Wnt signaling
Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell <i>in vitro</i> and <i>in vivo</i> targeting Wnt signaling Open
Wnt signaling pathway is aberrantly activated in a variety of cancers, especially in colorectal cancer and small molecule antagonists of Wnt/β-catenin signaling are attractive candidates for developing effective therapeutics. In the presen…
View article: Diffusion Kurtosis Imaging Detects Acute Microstructural Changes in White and Gray Matter after Alcohol Intoxication in Rat
Diffusion Kurtosis Imaging Detects Acute Microstructural Changes in White and Gray Matter after Alcohol Intoxication in Rat Open
Diffusion kurtosis imaging (DKI) is an extension of Diffusion tensor imaging (DTI) but based on a non-gaussian diffusion model, allowing more comprehensive characterization of microstructural changes in the brain.The aim of this research w…