Ling‐Na Han
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View article: Research on the prevention of tooth demineralization and the effects and mechanisms of different mineralization solutions on the metabolism of Streptococcus mutans
Research on the prevention of tooth demineralization and the effects and mechanisms of different mineralization solutions on the metabolism of Streptococcus mutans Open
Objective To compare the preventive effects of various mineralization solutions on tooth demineralization and their influence on the metabolism of Streptococcus mutans (S. mutans) . Methods Pure water, Ca/P mineralization solution, Ca/P mi…
View article: Synthesis of an amphiphilic bi-prodrug based on gossypol and cytarabine for drug self-delivery
Synthesis of an amphiphilic bi-prodrug based on gossypol and cytarabine for drug self-delivery Open
Drug–drug conjugates have become a research hotspot in nanomedicine.
View article: Cord blood metabolomics reveals gestational metabolic disorder associated with anti-thyroid peroxidase antibodies positivity
Cord blood metabolomics reveals gestational metabolic disorder associated with anti-thyroid peroxidase antibodies positivity Open
Background Thyroid disease is one of the common endocrine disorders affecting the pregnant women, in which thyroid autoimmunity can alter the progress and the outcome of pregnancy. Women with euthyroid status but anti-thyroid peroxidase (a…
View article: One-pot synthesis and enzyme-responsiveness of amphiphilic doxorubicin prodrug nanomicelles for cancer therapeutics
One-pot synthesis and enzyme-responsiveness of amphiphilic doxorubicin prodrug nanomicelles for cancer therapeutics Open
A doxorubicin-based nanomedicine with a one-pot synthesis method and FDA-approved materials could solve the problems of a complicated preparation process and avoid the use of non-FDA-approved materials for clinical use and industrial produ…
View article: Protective Effects of DAla2-GIP-GLU-PAL against Cognitive Deficits and Amyloid Deposition in APP/PS1 AD Mice Associated with Reduction of Neuroinflammation
Protective Effects of DAla2-GIP-GLU-PAL against Cognitive Deficits and Amyloid Deposition in APP/PS1 AD Mice Associated with Reduction of Neuroinflammation Open
Background Alzhermer’s disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and high-density deposition of amyloid-β (Aβ) plaques in the brain. Type 2 diabetes mellitus (T2DM) is an importa…
View article: Integrated microbiome–metabolome analysis reveals novel associations between fecal microbiota and hyperglycemia-related changes of plasma metabolome in gestational diabetes mellitus
Integrated microbiome–metabolome analysis reveals novel associations between fecal microbiota and hyperglycemia-related changes of plasma metabolome in gestational diabetes mellitus Open
Gestational diabetes mellitus (GDM) has been associated with circulating metabolic disorders and alterations in gut microbiota, respectively.