Lingxia Wang
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View article: Selective Effect of DNA N6-Methyladenosine Modification on Transcriptional Genetic Variations in East Asian Samples
Selective Effect of DNA N6-Methyladenosine Modification on Transcriptional Genetic Variations in East Asian Samples Open
Genetic variations and DNA modification are two common dominant factors ubiquitous across the entire human genome and induce human disease, especially through static genetic variations in DNA or RNA that cause human genetic diseases. DNA N…
View article: Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock
Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock Open
Caspase-8, a pivotal protease intricately involved in various cellular signaling pathways related to cell death and inflammation, has been identified as a contributor to cytokine production during septic shock. However, the mechanisms gove…
View article: Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications
Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications Open
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cell…
View article: Circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis
Circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis Open
Purpose Circular RNAs (circRNAs) appear to exert critical functions in breast cancer (BC). The objective of this study is to explore the usefulness of circRNAs as potential diagnostic and prognostic biomarkers of BC. Methods The Gene Expre…
View article: Liquid biopsy in ovarian cancer in China and the world: current status and future perspectives
Liquid biopsy in ovarian cancer in China and the world: current status and future perspectives Open
Ovarian cancer (OC) is the eighth most common cancer in women, but the mild, non-specific clinical presentation in early stages often prevents diagnosis until progression to advanced-stage disease, contributing to the high mortality associ…
View article: Excessive apoptosis of <i>Rip1</i> ‐deficient T cells leads to premature aging
Excessive apoptosis of <i>Rip1</i> ‐deficient T cells leads to premature aging Open
In mammals, the most remarkable T cell variations with aging are the shrinking of the naïve T cell pool and the enlargement of the memory T cell pool, which are partially caused by thymic involution. However, the mechanism underlying the r…
View article: Grass‐specific <scp>ABERRANT MICROSPORE DEVELOPMENT</scp> 1 is required for maintaining pollen fertility in rice
Grass‐specific <span>ABERRANT MICROSPORE DEVELOPMENT</span> 1 is required for maintaining pollen fertility in rice Open
SUMMARY Pollen development includes a series of biological events that require precise gene regulation. Although several transcription factors (TFs) have been shown to play roles in maintaining pollen fertility, the major regulatory networ…
View article: Caspase-8 Blocks Receptor-Interacting Protein Kinase-1 Kinase–Independent Necroptosis during Embryogenesis
Caspase-8 Blocks Receptor-Interacting Protein Kinase-1 Kinase–Independent Necroptosis during Embryogenesis Open
Caspase-8 (Casp8) suppresses receptor-interacting protein kinase-3 (RIPK3)/mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis, demonstrated by the genetic evidence that deletion of Ripk3 or Mlkl prevented embryonic letha…
View article: <i>SWOLLEN TAPETUM AND STERILITY 1</i> is required for tapetum degeneration and pollen wall formation in rice
<i>SWOLLEN TAPETUM AND STERILITY 1</i> is required for tapetum degeneration and pollen wall formation in rice Open
The pollen wall is important for protecting the male gametophyte and for fertilization. The lipid components of the pollen wall are mainly synthesized and transported from the sporophytic tapetum. Although several factors related to lipid …
View article: CircRNAs in Malignant Tumor Radiation: The New Frontier as Radiotherapy Biomarkers
CircRNAs in Malignant Tumor Radiation: The New Frontier as Radiotherapy Biomarkers Open
World Health Organization (WHO) data show that of the top 20 factors that threaten human life and health, cancer is at the forefront, and the therapeutic approaches for cancer consist of surgery, radiotherapy, chemotherapy and immunotherap…
View article: Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia
Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia Open
Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in diseases such as lymphoproliferation, immunodeficiency, and autoimmunity in h…
View article: miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5
miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5 Open
miRNAs play a crucial part in multiple biological processes of cell proliferation, migration, apoptosis, and chemoresistance. In cancer, miRNAs can be divided into oncogenes or tumor suppressors on the basis of their functions in the carci…
View article: Secretory lipid transfer protein OsLTPL94 acts as a target of EAT1 and is required for rice pollen wall development
Secretory lipid transfer protein OsLTPL94 acts as a target of EAT1 and is required for rice pollen wall development Open
SUMMARY The plant pollen wall protects the male gametophyte from various biotic and abiotic stresses. The formation of a unique pollen wall structure and elaborate exine pattern is a well‐organized process, which needs coordination between…
View article: Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development Open
ABIN1 is a polyubiquitin-binding protein known to regulate NF-κB activation and cell death signaling. Mutations in Abin1 can cause severe immune diseases in human, such as psoriasis, systemic lupus erythematosus, and systemic sclerosis. He…
View article: Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Background Rice ( Oryza sativa ) bacterial leaf blight (BLB), caused by the hemibiotrophic Xanthomonas oryzae pv. oryzae ( Xoo ), is one of the most devastating diseases affecting the production of rice worldwide. The development and use o…
View article: Mixed lineage kinase domain-like pseudokinase mediated necroptosis aggravates periodontitis progression
Mixed lineage kinase domain-like pseudokinase mediated necroptosis aggravates periodontitis progression Open
Necroptosis is a form of cell death that is reportedly involved in the pathogenesis of periodontitis. However, the role of Mlkl-involved necroptosis remains unclear. Herein, we aim to explore the role of MLKL-mediated necroptosis in period…
View article: Identification of rice (<i>Oryza sativa</i> L.) genes involved in sheath blight resistance via a genome‐wide association study
Identification of rice (<i>Oryza sativa</i> L.) genes involved in sheath blight resistance via a genome‐wide association study Open
Summary Rice sheath blight (RSB) is an economically significant disease affecting rice yield worldwide. Genetic resistance to RSB is associated with multiple minor genes, with each providing a minor phenotypic effect, but the underlying do…
View article: Additional file 12 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 12 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 12: Table S11. Statistics of Illumina transcriptome sequencing data.
View article: Additional file 8 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 8 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 8: Table S7. GWAS of P3 (2019) resiatance with 259 rice lines using the SNP-set generated by mapping reads to the Nipponbare.
View article: Additional file 3 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 3 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 3: Table S2. Sequence information on the genomes of 259 rice accessions.
View article: Additional file 11 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 11 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 11: Table S10. GWAS of P6 (2019) resiatance with 259 rice lines using the SNP-set generated by mapping reads to the Nipponbare.
View article: Additional file 9 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 9 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 9: Table S8. GWAS of P6 (BULP) resiatance with 259 rice lines using the SNP-set generated by mapping reads to the Nipponbare.
View article: Additional file 4 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 4 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 4: Table S3. Results of filtered SNP annotation.
View article: Additional file 13 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 13 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 13: Table S12. The list of DEGs in resistant line NSIC RC154 at different inoculation times.
View article: Additional file 16 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.)
Additional file 16 of Genome-wide association study and transcriptome analysis discover new genes for bacterial leaf blight resistance in rice (Oryza sativa L.) Open
Additional file 16: Table S15. Specific primers of candidate gene sequences for qRT-PCR.