Lingxiao Xu
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View article: Anti-MDA5 antibody IgG1 subtype is associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Anti-MDA5 antibody IgG1 subtype is associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis Open
Background Rapidly progressive interstitial lung disease (RP-ILD) is a severe, often fatal complication in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5 + DM). Early prediction of RP-…
View article: Ocular siderosis secondary to occult intraocular foreign body causing secondary glaucoma: A case report
Ocular siderosis secondary to occult intraocular foreign body causing secondary glaucoma: A case report Open
BACKGROUND Occult intraocular foreign bodies (IOFBs) can present with atypical symptoms and clinical signs, making diagnosis challenging. We describe a case of an undetected IOFB that was missed on both computed tomography and B-ultrasound…
View article: A new technique of scleral suture fixation for posterior chamber lenses
A new technique of scleral suture fixation for posterior chamber lenses Open
We present a novel scleral suture fixation technique for repositioning a dislocated intraocular lens (IOL). Methods: A 1 mL needle is used to guide and extract the double-armed 10-0 straight polypropylene suture through the paracentesis, p…
View article: Causal relationship between dermatomyositis and autoimmune d isorders: a Mendelian randomization study
Causal relationship between dermatomyositis and autoimmune d isorders: a Mendelian randomization study Open
Background Various autoimmune disorders have been linked to dermatomyositis (DM) based on findings from epidemiological studies. The objective of this study is to examine the causal association between autoimmune disorders and DM utilizing…
View article: Cutaneous ulcers in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease: a multicentre retrospective cohort study
Cutaneous ulcers in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease: a multicentre retrospective cohort study Open
Introduction To identify the clinical characteristics and risk factors for cutaneous ulcers in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+ DM) combined with rapidly progressiv…
View article: Nab-paclitaxel plus capecitabine as first-line treatment for advanced biliary tract cancers: An open-label, non-randomized, phase II clinical trial
Nab-paclitaxel plus capecitabine as first-line treatment for advanced biliary tract cancers: An open-label, non-randomized, phase II clinical trial Open
BACKGROUND Biliary tract cancers (BTCs) are a heterogeneous group of tumors with high malignancy, poor prognosis, and limited treatment options. AIM To explore the efficacy and safety of nab-paclitaxel plus capecitabine as first-line treat…
View article: Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery
Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery Open
Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on individuals and society. While the conventional use of immunosuppressants and disease‐modifying drugs has provided partial relief and control, their inevitable …
View article: Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis
Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis Open
View article: Rapidly progressive interstitial lung disease risk prediction in anti-MDA5 positive dermatomyositis: the CROSS model
Rapidly progressive interstitial lung disease risk prediction in anti-MDA5 positive dermatomyositis: the CROSS model Open
Background The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5 + DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) is these patients’ leading cause of dea…
View article: Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis Open
Background Anti-melanoma differentiation-associated gene five antibody positive (MDA5 + ) dermatomyositis (DM) is significantly associated with rapidly progressive interstitial lung disease (RP-ILD). Early detection of RP-ILD remains a maj…
View article: Additional file 1 of Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Additional file 1 of Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis Open
Additional file 1: Table S1. Differentially expressed proteins of MDA5+ DM versus healthy control.
View article: CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling
CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling Open
STING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, …
View article: Legal Dilemmas in the Regulation of Mergers and Acquisitions of Chinese Multinational Corporations in the Context of Comparative Law and its Response
Legal Dilemmas in the Regulation of Mergers and Acquisitions of Chinese Multinational Corporations in the Context of Comparative Law and its Response Open
The global economy is in a sustained recession due to the impact of the new epidemic. As one of the few economies 'bucking the trend', Chinese companies have been presented with new opportunities to invest and merge overseas. However, deca…
View article: Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis
Elevated serum B-cell activator factor levels predict rapid progressive interstitial lung disease in anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis Open
Background Rapid progressive interstitial lung disease (RP-ILD) is the leading cause of anti-melanoma differentiation associated protein 5 antibody positive dermatomyositis (anti-MDA5+DM) related death. Elevated serum B-cell act…
View article: Severeness of COVID-19 in patients with rheumatic diseases: A retrospective study from eastern China
Severeness of COVID-19 in patients with rheumatic diseases: A retrospective study from eastern China Open
Objective The aim of this study was to investigate the determinants associated with the severity of the Corona Virus Disease 2019 (COVID-19) among patients suffering from rheumatic diseases (RD) in light of the comprehensive recalibration …
View article: Piezo1 (Piezo-Type Mechanosensitive Ion Channel Component 1)-Mediated Mechanosensation in Macrophages Impairs Perfusion Recovery After Hindlimb Ischemia in Mice
Piezo1 (Piezo-Type Mechanosensitive Ion Channel Component 1)-Mediated Mechanosensation in Macrophages Impairs Perfusion Recovery After Hindlimb Ischemia in Mice Open
Background: Angiogenesis is a promising strategy for those with peripheral artery disease. Macrophage-centered inflammation is intended to govern the deficiency of the angiogenic response after hindlimb ischemia. However, little is known a…
View article: Interleukin‐29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling
Interleukin‐29 Accelerates Vascular Calcification via JAK2/STAT3/BMP2 Signaling Open
Background Vascular calcification (VC), associated with enhanced cardiovascular morbidity and mortality, is characterized by the osteogenic transdifferentiation of vascular smooth muscle cells. Inflammation promotes VC initiation and progr…
View article: 902 Loss-of-function variants in <i>SAT1</i> cause X-linked Childhood-onset Systemic Lupus Erythematosus
902 Loss-of-function variants in <i>SAT1</i> cause X-linked Childhood-onset Systemic Lupus Erythematosus Open
Objectives Families that contain multiple siblings affected with childhood-onset of systemic lupus erythematosus (SLE) likely have strong genetic predispositions. We performed whole-exome sequencing (WES) to identify familial rare risk var…
View article: Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus
Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus Open
View article: Prediction of acute kidney injury in patients with femoral neck fracture utilizing machine learning
Prediction of acute kidney injury in patients with femoral neck fracture utilizing machine learning Open
Background Acute kidney injury (AKI) is a common complication associated with significant morbidity and mortality in high-energy trauma patients. Given the poor efficacy of interventions after AKI development, it is important to predict AK…
View article: Serum Krebs von den Lungen-6 concentrations reflect severity of anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis associated interstitial lung disease
Serum Krebs von den Lungen-6 concentrations reflect severity of anti-melanoma differentiation-associated protein 5 antibody positive dermatomyositis associated interstitial lung disease Open
The serum KL-6 levels reflect severity of lung injury and serve as a clinically useful biomarker in detection and monitoring RP-ILD progression in anti-MDA5+DM patients.
View article: 1506 A human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages
1506 A human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages Open
Background We previously identified a p.Arg90His (p.R90H) hypomorphic variant of neutrophil cytosolic factor 1 (NCF1, a regulatory subunit of phagocyte NADPH oxidase 2 complex, NOX2) predisposes to multiple autoimmune diseases inclu…
View article: Interpretation of NCCN guidelines for hepatobiliary tumors V3 update in 2021
Interpretation of NCCN guidelines for hepatobiliary tumors V3 update in 2021 Open
View article: <scp>Up‐Regulated</scp> Interleukin‐10 Induced by <scp>E2F</scp> Transcription Factor 2–<scp>MicroRNA</scp>‐17‐5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus
<span>Up‐Regulated</span> Interleukin‐10 Induced by <span>E2F</span> Transcription Factor 2–<span>MicroRNA</span>‐17‐5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus Open
Objective Elevated interleukin‐10 (IL‐10) levels in patients with systemic lupus erythematosus (SLE) have B cell–promoting effects, contributing to autoantibody production and tissue damage. We aimed to characterize up‐regulated IL‐10+ B c…
View article: Adiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis
Adiponectin Enhances B-Cell Proliferation and Differentiation via Activation of Akt1/STAT3 and Exacerbates Collagen-Induced Arthritis Open
Although B cells have been shown to contribute to the pathogenesis of rheumatoid arthritis (RA), the precise role of B cells in RA needs to be explored further. Our previous studies have revealed that adiponectin (AD) is expressed at high …
View article: A case of episodic and refractory arthritis due to a novel variant of NLRP12
A case of episodic and refractory arthritis due to a novel variant of NLRP12 Open
View article: Correction to: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
Correction to: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis Open
Unfortunately, after publication of this article [1], it was noticed that the panel for Fig. 4b was inadvertently obscured during the production process. The full, correct Fig. 4 can be seen below and the original article has been correcte…
View article: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis Open
Our study provides new evidence of AD involvement in bone erosion. AD induces the expression of OPN, which recruits osteoclasts and initiates bone erosion. These data highlight AD as a novel target for RA treatment.
View article: Application of Corvis ST to evaluate the effect of femtosecond laser-assisted cataract surgery on corneal biomechanics
Application of Corvis ST to evaluate the effect of femtosecond laser-assisted cataract surgery on corneal biomechanics Open
The aim of the present study was to evaluate the effects of femtosecond laser-assisted cataract surgery (FLACS) and phacoemulsification on corneal biomechanics using corneal visualization Scheimpflug technology. The medical records of 50 e…
View article: Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5
Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5 Open
Receptor activator of nuclear factor κB ligand (RANKL) is critically involved in bone erosion of rheumatoid arthritis (RA). We previously reported association between younger age at onset of RA and a RANKL promoter SNP that conferred an el…