Lu Huang
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View article: The transcription factor GmBIM1 negatively regulates plant height in soybean (Glycine max L.)
The transcription factor GmBIM1 negatively regulates plant height in soybean (Glycine max L.) Open
View article: DepTR-MOT: Unveiling the Potential of Depth-Informed Trajectory Refinement for Multi-Object Tracking
DepTR-MOT: Unveiling the Potential of Depth-Informed Trajectory Refinement for Multi-Object Tracking Open
Visual Multi-Object Tracking (MOT) is a crucial component of robotic perception, yet existing Tracking-By-Detection (TBD) methods often rely on 2D cues, such as bounding boxes and motion modeling, which struggle under occlusions and close-…
View article: The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology
The intracellular agent of Q fever, <i>Coxiella burnetii</i> , alters human alveolar macrophage metabolism and mitochondrial physiology Open
Coxiella burnetii , the etiologic agent of Q fever, is a gram-negative intracellular bacterium that infects humans via contaminated aerosols typically while working with livestock. C. burnetii initially targets alveolar macrophages (AMs) t…
View article: miR-106b-5p downregulate KCNQ2 expression contributing to incisional pain in male rats
miR-106b-5p downregulate KCNQ2 expression contributing to incisional pain in male rats Open
View article: Dynamic changes in peripheral blood immunophenotyping and its prognostic value in cervical cancer patients undergoing immune checkpoint blockade therapy
Dynamic changes in peripheral blood immunophenotyping and its prognostic value in cervical cancer patients undergoing immune checkpoint blockade therapy Open
View article: Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma
Identification of RP‐54745, an IL‐1 Inhibitor Displaying Anticancer Activities for KSHV‐Related Primary Effusion Lymphoma Open
Kaposi's sarcoma‐associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including primary effusion lymphoma (PEL), usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin‐…
View article: TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3 Open
View article: Acoustic Recognition of Individual Animals in the Presence of Unknown Individuals
Acoustic Recognition of Individual Animals in the Presence of Unknown Individuals Open
Passive acoustic monitoring is firmly established as an effective non-invasive technique for wildlife monitoring. The analysis of animal vocalizations recorded in their natural habitats is commonly used to monitor species occupancy, distri…
View article: SHIP-1 regulates the differentiation and function of Tregs via inhibiting mTORC1 activity
SHIP-1 regulates the differentiation and function of Tregs via inhibiting mTORC1 activity Open
Cell metabolism is crucial for orchestrating the differentiation and function of regulatory T cells (Tregs). However, the underlying mechanism that coordinates cell metabolism to regulate Treg activity is not completely understood. As a pi…
View article: Retraction Note: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
Retraction Note: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells Open
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s40104-022-00787-z.
View article: Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages
Mannose receptor (MRC1) mediates uptake of dextran by bone marrow–derived macrophages Open
Macrophages survey their environment using receptor-mediated endocytosis and pinocytosis. Receptor-mediated endocytosis allows internalization of specific ligands, whereas pinocytosis nonselectively internalizes extracellular fluids and so…
View article: Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis
Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis Open
Macrophages maintain surveillance of their environment using receptor-mediated endocytosis and pinocytosis. Receptor-mediated endocytosis allows macrophages to recognize and internalize specific ligands whereas macropinocytosis non-selecti…
View article: Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice
Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice Open
Microplastics (MPs) and okadaic acid (OA) are known to coexist in marine organisms, potentially impacting humans through food chain. However, the combined toxicity of OA and MPs remains unknown. In this study, mice were orally administered…
View article: Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis Open
View article: SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome
SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome Open
Recent epidemiological studies suggest that individuals with Down syndrome are more susceptible to SARS-CoV-2 infection and have higher rates of hospitalization and mortality than the general population. However, the main drivers behind th…
View article: BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor recently emerged as a key regulator of host immunity to infections, autoimmune diseases and cancer. In this study, we investigated the role of Bhlhe40…
View article: <i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension
<i>P2X7</i> -Mediated Antigen-Independent Activation of CD8 <sup>+</sup> T Cells Promotes Salt-Sensitive Hypertension Open
BACKGROUND: CD8 + T cells (CD8Ts) have been implicated in hypertension. However, the specific mechanisms are not fully understood. In this study, we explore the contribution of the P2X7 (purinergic receptor P2X7) receptor to CD8T activatio…
View article: The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes
The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes Open
The ubiquitination of transmembrane receptors regulates endocytosis, intracellular traffic, and signal transduction. Bone marrow−derived macrophages from myeloid Cbl –/– and Cbl-b –/– double knockout (DKO) mice display sustained proliferat…
View article: TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis Open
Background Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily r…
View article: P380 Integrated fecal metagenome and serum metabolome analysis revealed gut microbiome associated serum metabolites as diagnostic biomarkers for inflammatory bowel disease
P380 Integrated fecal metagenome and serum metabolome analysis revealed gut microbiome associated serum metabolites as diagnostic biomarkers for inflammatory bowel disease Open
Background Gut microbiomes are altered among patients with IBD. Certain microbiome species were used as biomarkers for IBD diagnosis, yet with limited sensitivity and specificity, especially when used for the classification of UC and CD. G…
View article: Penicillin Binding Proteins-Based Immunoassay for the Selective and Quantitative Determination of Beta-Lactam Antibiotics
Penicillin Binding Proteins-Based Immunoassay for the Selective and Quantitative Determination of Beta-Lactam Antibiotics Open
View article: BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against<i>Chlamydia</i>
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against<i>Chlamydia</i> Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor recently emerged as a key regulator of host immunity to infections, autoimmune diseases and cancer. In this study, we investigated the role of Bhlhe40…
View article: Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating <i>Itgav</i> expression
Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating <i>Itgav</i> expression Open
Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis. Previous studies have shown that runt‐related transcription factor 2 (Ru…
View article: Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against <i>Mycobacterium tuberculosis</i>
Metabolism and ontogeny of alveolar macrophages contribute to peripheral trained immunity and confer protection against <i>Mycobacterium tuberculosis</i> Open
Lung alveolar macrophages (AMs) reside in the alveolar space and function as key sentinels to promote lung immune resilience. Notably, as the major cell target of early Mycobacterium tuberculosis (Mtb) infection, AMs provide a permissive c…
View article: Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor involved in cell cycle regulation and differentiation. It has recently emerged as a key player in immunity regulating T cell responses and cytokine pr…
View article: Fostering Knowledge Collaboration in Construction Projects: The Role of BIM Application
Fostering Knowledge Collaboration in Construction Projects: The Role of BIM Application Open
Knowledge collaboration is beneficial for project parties to assess valuable knowledge resources from others in order to enhance their competitive advantages. However, knowledge collaboration is hampered by the special project environment …
View article: Additional file 2 of m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma
Additional file 2 of m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma Open
Additional file 2: Table S2. Differential expression of m6a regulators in normal and tumor tissues in TCGA samples combined with GTEX samples.
View article: Additional file 3 of m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma
Additional file 3 of m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma Open
Additional file 3: Table S3. Table of M6A-related prognostic gene coefficients for model construction.
View article: RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells
RETRACTED ARTICLE: Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells Open
View article: Detection of the Inoculated Fermentation Process of Apo Pickle Based on a Colorimetric Sensor Array Method
Detection of the Inoculated Fermentation Process of Apo Pickle Based on a Colorimetric Sensor Array Method Open
Apo pickle is a traditional Chinese fermented vegetable. However, the traditional fermentation process of Apo pickle is slow, easy to ruin, and cannot be judged with regard to time. To improve fermentation, LP-165 (L. Plantarum), which has…