Lingyan Wu
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View article: The epigenetic basis of hepatocellular carcinoma – mechanisms and potential directions for biomarkers and therapeutics
The epigenetic basis of hepatocellular carcinoma – mechanisms and potential directions for biomarkers and therapeutics Open
View article: Atmospheric NH <sub>3</sub> in urban Beijing: long-term variations and implications for secondary inorganic aerosol control
Atmospheric NH <sub>3</sub> in urban Beijing: long-term variations and implications for secondary inorganic aerosol control Open
Ammonia (NH3) has major effects on the environment and climate. In situ measurements of NH3 concentrations taken between June 2009 and July 2020 at an urban site in Beijing were analyzed to study its long-term behavior, responses to meteor…
View article: ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage
ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage Open
The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous stu…
View article: Atmospheric NH <sub>3</sub> in urban Beijing: long-term variations and implications for secondary inorganic aerosol control
Atmospheric NH <sub>3</sub> in urban Beijing: long-term variations and implications for secondary inorganic aerosol control Open
Ammonia (NH3) has major effects on the environment and climate. In-situ measurements of NH3 concentrations taken between June 2009 and July 2020 at an urban site in Beijing were analyzed to study their long-term behaviors, responses to met…
View article: Effect of Lactobacillus plantarum ZFM4 in Helicobacter pylori-infected C57BL/6 mice: prevention is better than cure
Effect of Lactobacillus plantarum ZFM4 in Helicobacter pylori-infected C57BL/6 mice: prevention is better than cure Open
Objectives This study was performed to explore the preventive and therapeutic effects of Lactobacillus plantarum ZFM4 on H. pylori infections of the stomach tissue in C57BL/6 mice. Methods In this study, 40 specific-pathogen-free female C5…
View article: 68P The role of systemic reprogramming of GMPs in improving outcomes in glioblastoma
68P The role of systemic reprogramming of GMPs in improving outcomes in glioblastoma Open
Glioblastomas are grade IV gliomas of the central nervous system associated with a median survival rate of less than 15 months. Therefore, research has been focused on better understanding the role of the tumor immune microenvironment, spe…
View article: Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
View article: Supplementary Table 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Supplementary Table 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Supplementary Table 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
View article: Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
View article: Data from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Data from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Chronic inflammation is an important contributor to the development of lung cancers, one of the most common malignancies worldwide, but the underlying molecular mechanisms of inflammation that specifically cue cancer risk remain poorly und…
View article: Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Supplementary Figure 2 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
View article: Data from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Data from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Chronic inflammation is an important contributor to the development of lung cancers, one of the most common malignancies worldwide, but the underlying molecular mechanisms of inflammation that specifically cue cancer risk remain poorly und…
View article: Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma Open
Supplementary Figure 1 from Api6/AIM/Spα/CD5L Overexpression in Alveolar Type II Epithelial Cells Induces Spontaneous Lung Adenocarcinoma
View article: A genomic enhancer signature associates with hepatocellular carcinoma prognosis
A genomic enhancer signature associates with hepatocellular carcinoma prognosis Open
Lifestyle and environmental-related exposures are the important risk factors of hepatocellular carcinoma (HCC), suggesting that tumour-associated epigenetic dysregulations may significantly underpin HCC. We profiled tumour tissues and thei…
View article: Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Background Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is espe…
View article: Mimo Sampling Neural Network: Construction, Framework, and Prospect
Mimo Sampling Neural Network: Construction, Framework, and Prospect Open
View article: Additional file 2 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Additional file 2 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Additional file 2: Supplementary Table S2. List of up-regulated genes in the tumour samples compared to the adjacent normal samples from all-patients analysis. Supplementary Table S3. List of down-regulated genes in the tumour samples comp…
View article: Additional file 5 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Additional file 5 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Additional file 5: Supplementary Table S6. DEPC values for down-regulated genes from per-patient analyses.
View article: Additional file 4 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Additional file 4 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Additional file 4: Supplementary Table S5. DEPC values for up-regulated genes from per-patient analyses.
View article: Additional file 7 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Additional file 7 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Additional file 7: Supplementary Table S8. List of down-regulated genes in PG1 patients in comparison to PG0. Supplementary Table S9. List of up-regulated genes in PG1 patients in comparison to PG0.
View article: Additional file 1 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma
Additional file 1 of Multi-region sampling with paired sample sequencing analyses reveals sub-groups of patients with novel patient-specific dysregulation in Hepatocellular Carcinoma Open
Additional file 1: Supplementary Table S1. Sample information. Tumor and adjacent normal tissues collected from 90 HCC patients were used in this study. Among the 90 patients, there were 17 patients with multifocal HCC. Only 31 tumor tissu…
View article: Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study Open
Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity. Using one of the largest pr…
View article: Promoter Hypomethylation Is Responsible for Upregulated Expression of HAI-1 in Hepatocellular Carcinoma
Promoter Hypomethylation Is Responsible for Upregulated Expression of HAI-1 in Hepatocellular Carcinoma Open
An upregulated expression of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in hepatocellular carcinomas (HCC) associates with poor prognosis, but the underlying mechanism for expression regulation has not been elucidated. HAI…
View article: Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocyte-derived dendritic cells of goats in vitro
Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocyte-derived dendritic cells of goats in vitro Open
View article: Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an<i>in vitro</i>model for predicting drug hepatotoxicity
Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an<i>in vitro</i>model for predicting drug hepatotoxicity Open
As drug-induced hepatotoxicity represents one of the most common causes of drug failure, three-dimensionalin vitroliver platforms represent a fantastic toolbox to predict drug toxicity and reducein vivostudies and drug attrition rates.
View article: Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells
Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells Open
Early detection of lung cancer offers an important opportunity to decrease mortality while it is still treatable and curable. Thirteen secretory proteins that are Stat3 downstream gene products were identified as a panel of biomarkers for …
View article: The influence of relative humidity on the heterogeneous oxidation of sulfur dioxide by ozone on calcium carbonate particles
The influence of relative humidity on the heterogeneous oxidation of sulfur dioxide by ozone on calcium carbonate particles Open
View article: Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3′,2′:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2′,3′:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK)
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3′,2′:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2′,3′:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK) Open
View article: Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death
Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death Open
Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study, the low/nontoxic dosage of glaucocalyxin B…
View article: <i>In vitro</i> and <i>in vivo</i> correlates of physiological and neoplastic human Fallopian tube stem cells
<i>In vitro</i> and <i>in vivo</i> correlates of physiological and neoplastic human Fallopian tube stem cells Open
High‐grade serous cancer ( HGSC ) progresses to advanced stages without symptoms and the 5‐year survival rate is a dismal 30%. Recent studies of ovaries and Fallopian tubes in patients with BRCA1 or BRCA2 mutations have documented a pre‐me…