Feng Zhang
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View article: Air pollution exposure during pregnancy and low birth weight and macrosomia: the role of gestational diabetes mellitus
Air pollution exposure during pregnancy and low birth weight and macrosomia: the role of gestational diabetes mellitus Open
Background The relationship between environmental air pollution and birth weight has been established, However, there is limited research exploring the role of gestational diabetes in the relationship between air pollution exposure and bir…
View article: Multiple Traumas Accelerate the Transition from Cardiovascular Disease to Depression: A Multi-State Study (Preprint)
Multiple Traumas Accelerate the Transition from Cardiovascular Disease to Depression: A Multi-State Study (Preprint) Open
BACKGROUND Traumas are risk factors for both cardiovascular disease (CVD) and depression. However, the specific impacts of trauma on the critical transition from incident CVD to subsequent depression and mortality remain scarce. OBJECTI…
View article: G2B: an optimized lentiviral vector with enhanced titer and β-globin expression for improved β-thalassemia gene therapy
G2B: an optimized lentiviral vector with enhanced titer and β-globin expression for improved β-thalassemia gene therapy Open
Gene therapy using lentiviral vectors offers a promising alternative treatment for β-thalassemia, a common monogenic blood disorder. Although the BB305 vector has demonstrated long-term clinical success—enabling most β-thalassemia patients…
View article: Research on the Evolutionary Mechanism of University Faculty Engagement in Multi-agent Collaborative Innovation
Research on the Evolutionary Mechanism of University Faculty Engagement in Multi-agent Collaborative Innovation Open
Multi-agent collaborative innovation catalyses scientific progress and fuels sustainable economic and social development. Its effectiveness depends on close cooperation among university faculty, government, and enterprises. As key knowledg…
View article: Adherence to Medically Tailored Meals and Nutrition Counseling Among Vulnerable Patients with Lung Cancer Enrolled in a Food Is Medicine Intervention
Adherence to Medically Tailored Meals and Nutrition Counseling Among Vulnerable Patients with Lung Cancer Enrolled in a Food Is Medicine Intervention Open
View article: Life Damage Online Monitoring Technology of a Steam Turbine Rotor Start-Up Based on an Empirical-Statistical Model
Life Damage Online Monitoring Technology of a Steam Turbine Rotor Start-Up Based on an Empirical-Statistical Model Open
In order to achieve fast and accurate life damage online monitoring of the steam turbine rotor, it was significant to propose an empirical-statistical model using a machine learning algorithm instead of finite element simulation to improve…
View article: Translation and validation of the Birth Satisfaction Scale-Revised Indicator (BSS-RI) in Chinese
Translation and validation of the Birth Satisfaction Scale-Revised Indicator (BSS-RI) in Chinese Open
The study aimed to translate and validate the Chinese version of the Birth Satisfaction Scale-Revised Indicator (C-BSS-RI) and assess its psychometric properties. Conducted from April to August 2023 at three hospitals in Nantong, China, it…
View article: The impact of pretreatment drug resistance on ainuovirine‐based antiviral therapy in HIV‐infected patients: A subgroup analysis from the RACER study
The impact of pretreatment drug resistance on ainuovirine‐based antiviral therapy in HIV‐infected patients: A subgroup analysis from the RACER study Open
View article: Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database
Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database Open
Background Down syndrome (DS), a neurodevelopmental disorder caused by a chromosomal abnormality, poses a major burden on global health. Analyzing the disease burden of DS, both in China and globally, is crucial for refining public health …
View article: Pregnancy in Women With Klippel-Trenaunay Syndrome Complicated by Uterine Vascular Malformation: A Case Report and Literature Review.
Pregnancy in Women With Klippel-Trenaunay Syndrome Complicated by Uterine Vascular Malformation: A Case Report and Literature Review. Open
Klippel-Trenaunay syndrome (KTS) is a rare congenital vascular disorder characterized by the classical triad of cutaneous port-wine stain (capillary hemangioma), varicose veins, and hypertrophy of soft tissues and bones. KTS with uterine i…
View article: Associations of residential greenness with incident vascular diseases in middle-aged and older adults: A large prospective cohort study
Associations of residential greenness with incident vascular diseases in middle-aged and older adults: A large prospective cohort study Open
The relationship between residential greenness and chronic vascular diseases (VD) remains inconclusive. This study aimed to assess the associations between residential greenness and the incidence of new-onset VD. We analyzed data from a co…
View article: Hydrogeological characteristics and hydro-chemical environment of a karst aquifer system are determined by the presence of major ions, trace elements, and environmental isotopes
Hydrogeological characteristics and hydro-chemical environment of a karst aquifer system are determined by the presence of major ions, trace elements, and environmental isotopes Open
View article: Prophylactic proton pump inhibitor use and all-cause mortality in adult sepsis patients: a retrospective analysis based on the MIMIC-IV database
Prophylactic proton pump inhibitor use and all-cause mortality in adult sepsis patients: a retrospective analysis based on the MIMIC-IV database Open
Background Sepsis poses a significant threat to human health, and extensive research has examined the relationship between proton pump inhibitors (PPI) and adverse outcomes in patients with sepsis. However, a consensus on this issue remain…
View article: Exploration of the mechanism of a novel enhancer on buffalo muscle development
Exploration of the mechanism of a novel enhancer on buffalo muscle development Open
The developmental process of skeletal muscle involves a wide variety of regulatory factors. However, little has been reported regarding the function and mechanisms of enhancer regulation in buffalo skeletal muscle growth and development. I…
View article: Integrative Proteome and Transcriptome Analyses Reveal the Metabolic Disturbance of the Articular Cartilage in Kashin–Beck Disease, an Endemic Arthritis
Integrative Proteome and Transcriptome Analyses Reveal the Metabolic Disturbance of the Articular Cartilage in Kashin–Beck Disease, an Endemic Arthritis Open
The objective of this study was to elucidate the proteomic and transcriptomic alterations within the cartilage in Kashin–Beck disease (KBD) compared to a normal control. We conducted a comparison of the expression profiles of proteins, mRN…
View article: Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome
Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome Open
Male factors contribute to 50% of infertility cases, with 20%–30% of cases being solely attributed to male infertility. Helicase for meiosis 1 ( HFM1 ) plays a crucial role in ensuring proper crossover formation and synapsis of homologous …
View article: Practical Electrochemical Hydroxynitration and Chloronitration Bifunctionalization of Alkenes with NaNO<sub>2</sub>
Practical Electrochemical Hydroxynitration and Chloronitration Bifunctionalization of Alkenes with NaNO<sub>2</sub> Open
We herein developed a novel method for generating nitryl free radicals using sodium nitrite for the first time under electrocatalytic conditions. A series of vicinal hydroxynitro or chloronitro compounds was generated in good yields. This …
View article: Association of allostatic load with all‐cause and cause‐specific dementia: A prospective cohort study
Association of allostatic load with all‐cause and cause‐specific dementia: A prospective cohort study Open
INTRODUCTION Allostatic load (AL) serves as a valuable tool for objectively assessing the biological impact of chronic stress and has been implicated in dementia risk. This study aims to investigate the association between AL and all‐cause…
View article: Cloning and Functional Analysis of Glyoxalase I Gene BrGLYI 13 in Brassica rapa L.
Cloning and Functional Analysis of Glyoxalase I Gene BrGLYI 13 in Brassica rapa L. Open
Glyoxalase I (GLYI) is a key enzyme that detoxifies methylglyoxal, a toxic byproduct of glycolysis, and is essential for plant pollination. However, the genome-wide identification and functional analysis of GLYI in Brassica rapa L. (B. rap…
View article: P009 – The role of plasma ctDNA detection for CRPC patients with failure of first-line abiraterone/enzalutamide treatment
P009 – The role of plasma ctDNA detection for CRPC patients with failure of first-line abiraterone/enzalutamide treatment Open
View article: The IRF2-INPP4B pathway is activated in CD4+ T cells and aggravates acute myeloid leukemia development by inhibiting apoptosis
The IRF2-INPP4B pathway is activated in CD4+ T cells and aggravates acute myeloid leukemia development by inhibiting apoptosis Open
We revealed that IRF2-INPP4B signaling in CD4+ T-cells stimulated the JAK2-STAT3 signaling channel and downregulated caspase 3, reducing AML cell apoptosis and aggravating AML progression. This work highlights an important regul…
View article: Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways Open
Background The tyrosine receptor kinase inhibitor (TRKi) entrectinib is used to treat neurotrophic tyrosine receptor kinase (NTRK) fusion-positive solid tumors and ROS1-positive patients. Despite its impressive efficacy against cancer, the…
View article: Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study
Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study Open
View article: GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway Open
The Warburg effect, characterized by the shift toward aerobic glycolysis, is closely associated with the onset and advancement of tumors, including multiple myeloma (MM). Nevertheless, the specific regulatory mechanisms of glycolysis in MM…
View article: Newly developed DWI hyperintensities and changes in cerebral blood flow after carotid stent placement for unilateral symptomatic carotid artery stenosis
Newly developed DWI hyperintensities and changes in cerebral blood flow after carotid stent placement for unilateral symptomatic carotid artery stenosis Open
This study aimed to evaluate changes in cerebral blood flow and perioperative outcomes in patients with unilateral symptomatic carotid artery stenosis before and after carotid artery stenting (CAS), providing insights to guide surgical dec…
View article: Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease
Prevalence and Risk Factors of Depression in Patients With Endemic Osteoarthritis Kashin–Beck Disease Open
Background: Kashin–Beck disease (KBD) is an endemic osteoarthropathy, which occurs in children aged 3–12, with similarity to osteoarthritis (OA). Previous studies have shown significant depression symptoms in OA patients, yet no comparable…
View article: Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts
Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts Open
Aims Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among …
View article: Ultrasonic Pre-Treatment to Boost Sandiness and Flavor in Vacuum-Cured Salted Yolk
Ultrasonic Pre-Treatment to Boost Sandiness and Flavor in Vacuum-Cured Salted Yolk Open
View article: Hydrogeological Characteristics and Hydro-Chemical Environment of a Karst Aquifer System are Determined by the Presence of Major Ions, Trace Elements, and Environmental Isotopes
Hydrogeological Characteristics and Hydro-Chemical Environment of a Karst Aquifer System are Determined by the Presence of Major Ions, Trace Elements, and Environmental Isotopes Open
View article: Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury
Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury Open