Lingyan Yang
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View article: Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration
Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration Open
WNT signaling is an essential pathway regulating tissue morphogenesis and regeneration. However, harnessing the pathway for regenerative medicine has been challenging due to the lack of approaches to identify and deliver specific WNT ligan…
View article: Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease
Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease Open
The rising global prevalence of Alzheimer's disease (AD) and mild cognitive impairment (MCI) underscores the urgent need to elucidate their underlying pathogenic mechanisms.
View article: Strategies for increasing solubility of porphyrins in aqueous media
Strategies for increasing solubility of porphyrins in aqueous media Open
The development of cancer treatment technology has promoted the strategy and application of photosensitizers. The unique structural characteristics of porphyrin photosensitizers show strong photodynamic therapy and photothermal therapy cap…
View article: A precise design strategy for a cell-derived extracellular matrix based on CRISPR/Cas9 for regulating neural stem cell function
A precise design strategy for a cell-derived extracellular matrix based on CRISPR/Cas9 for regulating neural stem cell function Open
Extracellular matrix is a natural microenvironment pivotal for stem cell survival, as well as proliferation, differentiation and metastasis, composed of a variety of biological molecular complexes secreted by resident cells in tissues and …
View article: Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides
Specific anti‐glioma targeted‐delivery strategy of engineered small extracellular vesicles dual‐functionalised by Angiopep‐2 and TAT peptides Open
Glioma is one of the primary malignant brain tumours in adults, with a poor prognosis. Pharmacological reagents targeting glioma are limited to achieve the desired therapeutic effect due to the presence of blood‐brain barrier (BBB). Effect…
View article: The Promoted Generation of Basal Forebrain Cholinergic Neurons from Neural Progenitor Cells on Three-dimensional Graphene foam Scaffold
The Promoted Generation of Basal Forebrain Cholinergic Neurons from Neural Progenitor Cells on Three-dimensional Graphene foam Scaffold Open
Background: An early substantial loss of basal forebrain cholinergic neurons (BFCNs) is a common property of Alzheimer’s disease and the generation of functional BFCNs is related to learning and memory deficits. As a biocompatible and cond…
View article: Iron Hydroxide/Oxide-Reduced Graphene Oxide Nanocomposite for Dual-Modality Photodynamic and Photothermal Therapy In Vitro and In Vivo
Iron Hydroxide/Oxide-Reduced Graphene Oxide Nanocomposite for Dual-Modality Photodynamic and Photothermal Therapy In Vitro and In Vivo Open
Minimal invasive phototherapy utilising near-infrared (NIR) laser to generate local reactive oxygen species (ROS) and heat has few associated side effects and is a precise treatment in cancer therapy. However, high-efficiency and safe phot…
View article: Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis
Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis Open
Methicillin-resistant Staphylococcus aureus (MRSA) often induces chronic osteomyelitis and then bone defects. Here, gentamicin-loaded silk/nanosilver composite scaffolds were developed to treat MRSA-induced chronic osteomyelitis. AgNO 3 wa…
View article: Homologous Gold Nanoparticles and Nanoclusters Composites with Enhanced Surface Raman Scattering and Metal Fluorescence for Cancer Imaging
Homologous Gold Nanoparticles and Nanoclusters Composites with Enhanced Surface Raman Scattering and Metal Fluorescence for Cancer Imaging Open
A large number of deaths from cancer can be attributed to the lack of effective early-stage diagnostic techniques. Thus, accurate and effective early diagnosis is a major research goal worldwide. With the unique phenomenon of localized sur…
View article: ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2
ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2 Open
We have identified novel actin filaments defined by tropomyosin Tpm4.2 at the ER. EM analysis of mouse embryo fibroblasts (MEFs) isolated from mice expressing a mutant Tpm4.2 ( Tpm4 Plt53/Plt53 ), incapable of incorporating into actin fila…
View article: Hydrophilic cell-derived extracellular matrix as a niche to promote adhesion and differentiation of neural progenitor cells
Hydrophilic cell-derived extracellular matrix as a niche to promote adhesion and differentiation of neural progenitor cells Open
Cell-derived extracellular matrix exhibits excellent adhesion performance for neural progenitor cell anchoring and residency, resulting in promoted proliferation of the stem cells to basal forebrain cholinergic neurons.
View article: An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake Open
This article corrects: An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake, authors: Anthony J. Kee, Lingyan Yang, Christine A. Lucas, Michael J. Greenberg, Nick Martel, Gary M. Leong, William E. Hughes,…
View article: An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake Open
Actin has an ill‐defined role in the trafficking of GLUT4 glucose transporter vesicles to the plasma membrane ( PM ). We have identified novel actin filaments defined by the tropomyosin Tpm3.1 at glucose uptake sites in white adipose tissu…