Lingyan Yuan
YOU?
Author Swipe
View article: AB‐Panda: An AI‐Generated Antibody Structure‐Based Tool for Developability Prediction
AB‐Panda: An AI‐Generated Antibody Structure‐Based Tool for Developability Prediction Open
The developability of antibodies is a critical concern in antibody discovery, encompassing issues such as self‐interaction, aggregation, and thermal stability. The use of computational and structure‐based tools has greatly improved the eva…
View article: Metabolic-immune crosstalk in myocardial infarction: RLF and SMCHD1 identified as causal therapeutic targets via integrated lactylation-MR analysis
Metabolic-immune crosstalk in myocardial infarction: RLF and SMCHD1 identified as causal therapeutic targets via integrated lactylation-MR analysis Open
Background The diagnosis of Myocardial Infarction (MI) requires the discovery of specific diagnostic biomarkers beyond high-sensitivity cardiac troponins. To identify causal MI-associated genes regulated by lactylation modification and elu…
View article: Anlotinib plus sintilimab as first-line treatment for patients with advanced colorectal cancer (APICAL-CRC): an open-label, single-arm, phase II trial
Anlotinib plus sintilimab as first-line treatment for patients with advanced colorectal cancer (APICAL-CRC): an open-label, single-arm, phase II trial Open
This is an investigator-initiated, open-label, single-arm, phase II trial that aimed to assess the combination of sintilimab plus anlotinib among patients with treatment-naïve metastatic colorectal cancer (mCRC) (APICAL-CRC ClinicalTrials.…
View article: Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia
Predictive Significance of Admission-Day Blood Routine-Derived Indices for 30-Day Mortality Risk in Elderly Patients with Bacterial Pneumonia Open
In elderly patients with community-acquired bacterial pneumonia, increased NLR, SII, SIRI and NMLR can predict 30-day mortality to a certain extent, but further multicenter studies are needed to verify.
View article: Deciphering radiopharmaceutical mechanisms through integrated proteomic and PTM-proteomic profiling
Deciphering radiopharmaceutical mechanisms through integrated proteomic and PTM-proteomic profiling Open
Schematic overview of the experimental workflow. The multi-level proteomic workflow for phospho-proteome, glycoproteome and proteome analyses of the mechanism of radiopharmaceuticals.
View article: Immunotherapy-based regimens for patients with EGFR-mutated non-small cell lung cancer who progressed on EGFR-TKI therapy
Immunotherapy-based regimens for patients with EGFR-mutated non-small cell lung cancer who progressed on EGFR-TKI therapy Open
The sustained benefit of immunotherapy-based regimens in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) after EGFR-tyrosine kinase inhibitor (TKI) failure is debatable. Neither Checkmate-722 nor Keynote-…
View article: Bulk and single-cell transcriptome analyses of islet tissue unravel gene signatures associated with pyroptosis and immune infiltration in type 2 diabetes
Bulk and single-cell transcriptome analyses of islet tissue unravel gene signatures associated with pyroptosis and immune infiltration in type 2 diabetes Open
Introduction Type 2 diabetes (T2D) is a common chronic heterogeneous metabolic disorder. However, the roles of pyroptosis and infiltrating immune cells in islet dysfunction of patients with T2D have yet to be explored. In this study, we ai…
View article: Targeted therapy for intractable cancer on the basis of molecular profiles: An open-label, phase II basket trial (Long March Pathway)
Targeted therapy for intractable cancer on the basis of molecular profiles: An open-label, phase II basket trial (Long March Pathway) Open
Purpose We evaluated he effects of molecular guided-targeted therapy for intractable cancer. Also, the epidemiology of druggable gene alterations in Chinese population was investigated. Materials and methods The Long March Pathway (Clinica…
View article: Objective study of the facial parameters of observations in patients with type 2 diabetes mellitus by machine learning
Objective study of the facial parameters of observations in patients with type 2 diabetes mellitus by machine learning Open
The influence of facial features is physical factor. Thus, the objective parameters of facial features should be specific to differential diagnosis of T2DM.
View article: Durable Clinical Response to ALK Tyrosine Kinase Inhibitors in Epithelioid Inflammatory Myofibroblastic Sarcoma Harboring PRRC2B-ALK Rearrangement: A Case Report
Durable Clinical Response to ALK Tyrosine Kinase Inhibitors in Epithelioid Inflammatory Myofibroblastic Sarcoma Harboring PRRC2B-ALK Rearrangement: A Case Report Open
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm and patients with IMT tend to have a favorable outcome after complete surgical resection. However, some tumors of IMT cases have recurred and grown rapidly after succe…
View article: Study on the gene signature related to immune microenvironment on viral and nonviral infections of hepatocellular carcinoma
Study on the gene signature related to immune microenvironment on viral and nonviral infections of hepatocellular carcinoma Open
The pathogenesis of hepatocellular carcinoma (HCC) can be divided into viral infection (VIR) and nonviral (NVIR) infection. Two types of HCC performed different tumor immune microenvironment (TIME) which directly affected prognosis of HCC.…
View article: Integrated analysis of circRNA-miRNA-mRNA network reveals potential prognostic biomarkers for radiotherapies with X-rays and carbon ions in non-small cell lung cancer
Integrated analysis of circRNA-miRNA-mRNA network reveals potential prognostic biomarkers for radiotherapies with X-rays and carbon ions in non-small cell lung cancer Open
Our results provide a complete understanding to the regulatory mechanism of the sensitivities to low-LET X-ray and high-LET carbon ion irradiations, and might be helpful to screen potential biomarkers for predicting the Carbon-ion radiothe…
View article: Identification of a Prognostic Signature of Malignant Melanoma Based on Tumor Immune Microenvironment Exploration
Identification of a Prognostic Signature of Malignant Melanoma Based on Tumor Immune Microenvironment Exploration Open
Background: In contrast to identification of well-defined oncogenic alterations like BRAF mutations for malignant melanoma (MM) patient stratification, effective selection of predictive biomarkers remains a challenge in the era of checkpoi…
View article: The Mechanism of Jinqi Jiangtang Tablet in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology
The Mechanism of Jinqi Jiangtang Tablet in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology Open
Background: Type 2 Diabetes Mellitus(T2DM) is an endocrine disease that caused mainly by insulin resistance (IR) and β cell dysfunction. The incidence of T2DM is quite high in the worldwide. To explore the molecular mechanism of Jinqi Jian…
View article: Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma
Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma Open
View article: The effectiveness of afatinib and osimertinib in a Chinese patient with advanced lung adenocarcinoma harboring a rare triple EGFR mutation (R670W/H835L/L833V): a case report and literature review
The effectiveness of afatinib and osimertinib in a Chinese patient with advanced lung adenocarcinoma harboring a rare triple EGFR mutation (R670W/H835L/L833V): a case report and literature review Open
In patients without tissue availability at presentation, the analysis of cell-free DNA derived from liquid biopsy samples, in particular from plasma, represents an established alternative for providing epidermal growth factor receptor (EGF…
View article: Adenosquamous carcinoma of the bile duct: a population-based study
Adenosquamous carcinoma of the bile duct: a population-based study Open
Cancer-directed surgery and a primary lesion site of the ampulla of Vater may suggest favorable prognosis for patients with ASC of the bile duct.
View article: [Advances in Patient Derived Tumor Xenograft (PDTX) Model from Lung Cancer].
[Advances in Patient Derived Tumor Xenograft (PDTX) Model from Lung Cancer]. Open
With the development of tumor molecular biology and genomics, it has been recognized that there are great heterogeneity in the biological characteristics, molecular typing and reactivity of the same tumor species among different individual…
View article: Paralytic ileus due to a novel anticancer drug, nab-paclitaxel: A case report
Paralytic ileus due to a novel anticancer drug, nab-paclitaxel: A case report Open
Nab-paclitaxel is a recently emerged chemotherapy drug, which is widely used for the treatment of multiple types of cancer. The prospects of this novel drug are very bright as a result of its higher efficacy and lower toxicity compared wit…