Lixing Zhan
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View article: Sex-specific expression and function of TRIM28 during mouse primordial germ differentiation
Sex-specific expression and function of TRIM28 during mouse primordial germ differentiation Open
Mammalian primordial germ cells (PGCs) are embryonic precursors to the adult germline and must facilitate high-fidelity transfer of genomic material from one generation to the next. Transposable elements (TEs) represent an ongoing threat t…
View article: Exosomal miR-2137 from cadmium-treated hepatocytes drives renal ferroptosis via GPX4 suppression and is alleviated by selenium
Exosomal miR-2137 from cadmium-treated hepatocytes drives renal ferroptosis via GPX4 suppression and is alleviated by selenium Open
Cadmium (Cd) is a toxic heavy metal that primarily affects the liver and kidneys. Despite greater Cd accumulation in the liver, Cd-induced oxidative damage is more pronounced in the kidney, suggesting the involvement of hepatorenal communi…
View article: Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment
Selenoprotein P Deficiency Drives Hepatocellular Carcinoma Progression via Induction of Neutrophil Senescence and Immunosuppressive Microenvironment Open
The tumor immune microenvironment (TIME) is critically shaped by immunosuppressive neutrophils, yet the molecular mechanisms underlying the functional reprogramming of these neutrophils remain poorly understood. Here, through integrative a…
View article: Scribble deficiency promotes colon inflammation by inhibiting autophagy-dependent oxidative stress elimination
Scribble deficiency promotes colon inflammation by inhibiting autophagy-dependent oxidative stress elimination Open
Background： Scribble, a master scaffold in apical-basal polarity, proliferation and epithelial integrity. Current knowledge about the biological function of Scribble in the colonic epithelial plasticity/regeneration during intestinal infla…
View article: Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth
Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth Open
Background Colorectal cancer (CRC) remains the most common gastrointestinal cancer and a leading cause of cancer deaths worldwide, with most showing pathologies indicating the malignant transformation of early stage intestinal stem cells. …
View article: miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <i>PTEN</i>
miR‑224‑5p regulates the proliferation, migration and invasion of pancreatic mucinous cystadenocarcinoma by targeting <i>PTEN</i> Open
Pancreatic mucinous cystadenocarcinoma (MCC) is a rare malignant tumor, with a limited number of studies. The present study aimed to investigate the function and mechanism of microRNA (miR)‑224‑5p on proliferation, migration and invasion o…
View article: Autophagy promotes malignant migration and invasion via miR‑224‑5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells
Autophagy promotes malignant migration and invasion via miR‑224‑5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells Open
The prognosis of invasive pancreatic mucinous cystadenocarcinoma (MCC) is poor, and the molecular mechanism underlying its development remains unclear. The present study aimed to explore the potential role of autophagy in pancreatic MCC. T…
View article: miR‑502‑5p inhibits the proliferation, migration and invasion of gastric cancer cells by targeting SP1
miR‑502‑5p inhibits the proliferation, migration and invasion of gastric cancer cells by targeting SP1 Open
Gastric cancer (GC) is the third most common cause of cancer-associated mortality in China. Aberrant microRNA (miR) expression can occur through multiple biological processes and has been implicated in cancer development. However, to the b…
View article: Correction: IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson’s disease
Correction: IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson’s disease Open
Since online publication of this article, the authors noticed that some of the fly stocks were mislabelled in the methods and in Supplementary Figure 5. The corrected methods text is provided below.
View article: Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling
Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling Open
Our study revealed that polarity protein Scribble increased cisplatin-induced ROS generation and is beneficial to chemotherapeutic outcomes in NSCLC. Although Scribble deficiency tends to lead to cisplatin resistance by Nox2/ROS and Nrf2/P…
View article: Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner
Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner Open
Insulin resistance is a major contributing factor in the development of metabolic disease. Although numerous functions of the polarity protein AF6 (afadin and MLLT4) have been identified, a direct effect on insulin sensitivity has not been…
View article: Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways
Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with a marked potential for invasion and metastasis. Emerging evidence has suggested that dysregulation of long non-coding RNAs (lncRNAs) is associated with th…
View article: LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment
LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment Open
Metastasis to distant organs is a particularly ominous feature of malignant cancer. LKB1 (also known as STK11) has been identified as a tumor suppressor in several types of cancers. Here, we show that LKB1 is at low levels and is negativel…
View article: SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug
SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug Open
Tumor metastasis and invasion are both hallmarks of cancer malignancy and the leading cause of cancer death. Here we show that the adaptor protein SORBS1 (Sorbin and SH3 domain-containing protein 1, also known as CAP/ponsin) is expressed a…
View article: Prevalence of ABCB4 polymorphisms in gallstone disease in han-Chinese population.
Prevalence of ABCB4 polymorphisms in gallstone disease in han-Chinese population. Open
ATP Binding Cassette Transporter A4 (ABCB4) is a sterol export pump that regulates excretion of biliary cholesterol. We tested association between ABCB4 polymorphisms and gallstone disease using meta-analysis. In a cross-sectional study, 2…