Lingyun Long
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View article: Supplementary Figure S8 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S8 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S8 shows that KAT6A/7 and Menin inhibition have combinatorial effects in vivo.
View article: Supplementary Figure S1 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S1 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S1 shows that some NUP98 fusions drive cell transformation and leukemogenesis.
View article: Supplementary Figure S7 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S7 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S7 shows that KAT6A/7 and Menin inhibition alter gene expression and remodel chromatin in NUP98-rearranged cells.
View article: Data from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Data from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
NUP98 fusion oncoproteins (FO) are a hallmark of childhood acute myeloid leukemia. NUP98 FOs drive leukemogenesis through phase-separated condensate formation and maintenance of an active chromatin landscape at stem cell–associated genes i…
View article: Supplementary Figure S4 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S4 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S4 shows that MYST family histone acetyltransferase complex members are molecular dependencies in NUP98-rearranged cells.
View article: Supplementary Tables S1-S17 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Tables S1-S17 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Table S1. Exonic mutations/indels in Nup98::Kdm5a;Vav-Cre tumors developing after bone marrow transplant Supplementary Table S2. Exonic mutations/indels in spontaneous Nup98::Kdm5a;Vav-Cre tumors Supplementary Table S3. Enric…
View article: Supplementary Figure S3 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S3 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S3 shows that NUP98 fusion oncoproteins interact with MYST family histone acetyltransferase complex members.
View article: Supplementary Figure S5 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S5 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S5 shows that NUP98-rearranged cells respond to KAT6A/7 inhibition in vitro and in vivo.
View article: Supplementary Figure S2 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S2 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S2 shows that Nup98::Kdm5a;Vav-Cre mice spontaneously develop myeloid disease.
View article: Supplementary Figure S6 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Figure S6 from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Figure S6 shows that KAT6A/7 and Menin inhibition have synergistic effects in NUP98-rearranged cells.
View article: Supplementary Methods and Results from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia
Supplementary Methods and Results from KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
Supplementary Methods, Supplementary Results
View article: PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis
PPDPF promotes the progression of esophageal squamous cell carcinoma via c-Myc/CD24 axis Open
Background Despite a series of attempts during the last decades, the prognosis for esophageal squamous cell carcinoma (ESCC) remains poor. Although clinical immunotherapy trials have shown encouraging results, their benefits are limited. T…
View article: KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i> -Rearranged Acute Myeloid Leukemia
KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in <i>NUP98</i> -Rearranged Acute Myeloid Leukemia Open
NUP98 fusion oncoproteins (FO) are a hallmark of childhood acute myeloid leukemia. NUP98 FOs drive leukemogenesis through phase-separated condensate formation and maintenance of an active chromatin landscape at stem cell–associated genes i…
View article: MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in<i>NUP98</i>-Rearranged Acute Myeloid Leukemia
MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in<i>NUP98</i>-Rearranged Acute Myeloid Leukemia Open
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML) and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However, the composition and consequences of NU…
View article: [Application and research advances of delayed sural neurotrophic vascular flap for diabetic foot ulcers].
[Application and research advances of delayed sural neurotrophic vascular flap for diabetic foot ulcers]. Open
Diabetic foot ulcer is one of the serious complications of diabetes. Diabetic wounds are of great difficulty to repair, causing a high amputation rate and a great burden to patients and their family members and society. Researches showed t…
View article: [Clinical repair strategy for ischial tuberosity pressure ulcers based on the sinus tract condition and range of skin and soft tissue defects].
[Clinical repair strategy for ischial tuberosity pressure ulcers based on the sinus tract condition and range of skin and soft tissue defects]. Open
Objective: To investigate the clinical repair strategy for ischial tuberosity pressure ulcers based on the sinus tract condition and range of skin and soft tissue defects. Methods: The study was a retrospective observational …
View article: XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis
XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis Open
Metastasis is the main cause of colorectal cancer (CRC)-related death, and the 5-year relative survival rate for CRC patients with distant metastasis is only 14%. X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a zinc-…
View article: Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma Open
Neoadjuvant immune checkpoint blockade (ICB) demonstrates promise in operable esophageal squamous cell carcinoma (ESCC), but lacks available efficacy biomarkers. Here, we perform single-cell RNA-sequencing of tumors from patients with ESCC…
View article: CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity Open
View article: Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B
Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B Open
Photoactivated phytochrome B (PHYB) binds to antagonistically acting PHYTOCHROME-INTERACTING transcription FACTORs (PIFs) to regulate hundreds of light responsive genes in Arabidopsis by promoting PIF degradation. However, whether PHYB dir…
View article: Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine Open
View article: Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by <i>Arabidopsis</i> phytochrome B
Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by <i>Arabidopsis</i> phytochrome B Open
Phytochrome B (PHYB) triggers diverse light responses in Arabidopsis by binding to a group of antagonistically acting PHYTOCHROME-INTERACTING transcription FACTORs (PIFs) to promote PIF degradation, consequently downregulating PIF target g…
View article: Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR–T-cell responses against ALL
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR–T-cell responses against ALL Open
Chimeric antigen receptor (CAR)–T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few re…
View article: In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions Open
View article: Lipid signalling enforces functional specialization of Treg cells in tumours
Lipid signalling enforces functional specialization of Treg cells in tumours Open
View article: Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells Open
View article: [Interaction between PSF and cytokeratin 18 mediates PSF relocation to cell membrane and maintains chemosensitivity of myeloid leukemia].
[Interaction between PSF and cytokeratin 18 mediates PSF relocation to cell membrane and maintains chemosensitivity of myeloid leukemia]. Open
K18 is the intracellular chaperonin of PSF. The interaction of PSF and K18 mediates its redistribution to cell membrane in sensitive cells. While in resistant cells, PSF failed to relocate at the cell surface and accumulated in cells, whic…
View article: mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions
mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions Open
The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates signals from the environment to coordinate downstream signaling events and va…
View article: Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy Open
View article: [An interlaboratory comparison study on the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels].
[An interlaboratory comparison study on the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels]. Open
Objective: To investigate the current status and real performance of the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels in China through interlaboratory comparison. Methods: Peking University Pe…