Explanipedia

Salt-inducible kinase 1 is a key gene in suppressing EVD68-induced asthma by modulating antiviral immunity Open

Juntong Liu, Yue Wang, Lingyun Zou, Xinyue Han, Mingqi Lv , et al. · 2025

Single-cell RNA sequencing reveals immunological link between house dust mite allergy and childhood asthma Open

Lingyun Zou, Kang Chen, Xueqi Hong, Bo Ye · 2025

Allergic asthma in children is typically associated with house dust mites (HDM) as the key allergen. Nevertheless, the diagnostic rate remains below 60% due to the absence of specific symptoms and diagnostic markers, which hinders the impl…

Global, Regional, and National Burdens of Maternal Disorders and Mortality Among Women Aged 15–49 Years, 1990–2021: Insights from the Global Burden of Disease Study 2021 Open

Mengxi Wang, Lina Zhou, Wenyi Tang, Lingyun Zou · 2025

Developmental characteristics and control effects of myopia and eye diseases in children and adolescents: a school-based retrospective cohort study in Southwest China Open

Wenyi Tang, Tao Tan, Jiang Lin, Xin Wang, Bo Ye , et al. · 2024

Objectives To characterise the prevalence of myopia and eye diseases among school adolescents and children in Southwest China, and to evaluate the effectiveness of myopia control tools. Design Retrospective cohort study. Setting Across 95 …

Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA Open

Lina Zhou, Wenyi Tang, Bo Ye, Lingyun Zou · 2024

Human extrachromosomal circular DNA, or eccDNA, has been the topic of extensive investigation in the last decade due to its prominent regulatory role in the development of disorders including cancer. With the rapid advancement of experimen…

In silico analysis of intestinal microbial instability and symptomatic markers in mice during the acute phase of severe burns Open

Bochen Hou, Honglan Zhang, Lina Zhou, Biao Hu, Wenyi Tang , et al. · 2024

Risk prediction for severe COVID-19 progressing to critical illness and death in the ICU and efficacy analysis of using traditional Chinese medicine Open

Wenyi Tang, Bo Ye, Lina Zhou, Lingyun Zou · 2024

To reveal the key factors influencing the progression of severe COVID-19 to critical illness and death in the intensive care unit (ICU) and to accurately predict the risk, as well as to validate the efficacy of treatment using traditional …

Stillbirth trends by maternal socioeconomic status among a large internal migrant population in Shenzhen China over 10 years: a retrospective study Open

Lingyun Zou, Rui Ma · 2024

Objectives To estimate the stillbirth rate at 28 or more gestational weeks and associated maternal socioeconomic characteristics among a large internal migrant population in China. Design Retrospective study Setting Shenzhen Birth Registry…

Inflammatory linear verrucous epidermal nevus in groin and labia with claudication: Successfully treated with photodynamic therapy Open

Li Wei, Lu Yu, Lingyun Zou, Lin Ma · 2024

ALA PDT might be an effective and promising treatment for ILVEN in the future.

Antibacterial endotracheal tube with silver-containing double-network hydrogel coating Open

Chanchan Hu, Yan Yu, Hong-lin Qian, Yifeng Chen, Lingyun Zou , et al. · 2023

In this study, a double-network hydrogel coating with silver loading was developed for antibacterial catheters using an in-situ photoinitiation method, a stepwise immersion process, and ion exchange. The silver-loading capacity, release ki…

The function and regulation of CCAAT/enhancer binding protein ε Open

Shaowen Cheng, Jian Yang, Yudie Wang, Lina Xian, Zhihua Hu , et al. · 2023

In recent years, studies on the structure, function, and regulation of the C/EBPε gene have become an essential topic in the field of many diseases. CCAAT/enhancer-binding protein ε (C/EBPε) is the fifth member of the transcription factor …

Predicting pneumonia during hospitalization in flail chest patients using machine learning approaches Open

Xiaolin Song, Hui Li, Qingsong Chen, Tao Zhang, Guang-Bin Huang , et al. · 2023

Objective Pneumonia is a common pulmonary complication of flail chest, causing high morbidity and mortality rates in affected patients. The existing methods for identifying pneumonia have low accuracy, and their use may delay antimicrobial…

EccBase: A high-quality database for exploration and characterization of extrachromosomal circular DNAs in cancer Open

Haiyang Sun, Xinyi Lu, Lingyun Zou · 2023

Extrachromosomal circular DNAs (eccDNAs) are widely observed in eukaryotes. Previous studies have demonstrated that eccDNAs are essential to cancer progression, and found that they can not only express in normal cells to regulate RNA, but …

Trends and characteristics of multiple births in Baoan Shenzhen: A retrospective study over a decade Open

Wenyi Tang, Lingyun Zou · 2022

Background Shenzhen has the largest and youngest foreign population among all cities in China. The reproductive health of pregnant women from different backgrounds is a social issue that deserves attention. In the past decade, China has li…

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface Open

Nan Zhao, Xiaoxun Zhang, Jingjing Ding, Qiong Pan, Ming‐Hua Zheng , et al. · 2022

Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces fatty acid (FA) oxidation. Here, we identified 17 individuals w…

Stillbirth trends by maternal sociodemographic characteristics among a large internal migrant population in Shenzhen, China, over a 10-year period: a retrospective study Open

Rui Ma, Lingyun Zou · 2022

Pivotal Dominant Bacteria Ratio and Metabolites Related to Healthy Body Index Revealed by Intestinal Microbiome and Metabolomics Open

Lingyun Zou · 2021

A homozygous R148W mutation in <i>Semaphorin 7A</i> causes progressive familial intrahepatic cholestasis Open

Qiong Pan, Gang Luo, Jiaquan Qu, Sheng Chen, Xiaoxun Zhang , et al. · 2021

Ten-year time trends in preterm birth during a sociodemographic transition period: a retrospective cohort study in Shenzhen, China Open

Rui Ma, Yali Luo, Jun Wang, Yanxia Zhou, Haiyang Sun , et al. · 2020

Objectives To investigate time trends of preterm birth and estimate the contributions of risk factors to the changes in preterm birth rates over a decade (2009–2018) of transitional period in Shenzhen, China. Design Retrospective cohort st…

Emerging nanobiomaterials against bacterial infections in postantibiotic era Open

Dengfeng Hu, Lingyun Zou, Yifan Gao, Qiao Jin, Jian Ji · 2020

Although numerous antibiotics have been developed and applied in clinic, bacterial infections are still serious threats to human health, due to the rapidly growing antibiotic resistance all over the world. The causes of antibiotic resistan…

Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy Open

Dengfeng Hu, Lingyun Zou, Weijiang Yu, Fan Jia, Haijie Han , et al. · 2020

Biofilms are chief culprits of most intractable infections and pose great threats to human health. Conventional antibiotic therapies are hypodynamic to biofilms due to their strong drug resistance, closely related with biofilm hypoxia. A n…

CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation Open

Lixin Xiang, Qian Ran, Li Chen, Yang Xiang, Fengjie Li , et al. · 2020

Crif1 promotes RANKL expression via the cAMP/PKA pathway, which induces osteoclastogenesis by binding to receptor activator of nuclear factor κB on monocytes-macrophages in the mouse model. These results suggest a role for Crif1 in …

Characterization of Oral Microbiome and Exploration of Potential Biomarkers in Patients with Pancreatic Cancer Open

Haiyang Sun, Xia Zhao, Yanxia Zhou, Jun Wang, Rui Ma , et al. · 2020

Pancreatic cancer (PC) is highly malignant and lacks an effective therapeutic schedule, hence that early diagnosis is of great importance to achieve a good prognosis. Oral bacteria have been proved to be associated with pancreatic cancer, …

Crif1 Promotes Osteoporosis in Mice after Radiation Open

Lixin Xiang, Li Chen, Yang Xiang, Fengjie Li, Xiaomei Zhang , et al. · 2019

Radiation induces rapid bone loss and enhances bone resorption and RANKL expression. RANKL provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption. However, the mechanisms of radiatio…

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells Open

Huifeng Pi, Min Li, Lingyun Zou, Min Yang, Ping Deng , et al. · 2018

Cadmium (Cd) is a toxic metal that is widely found in numerous environmental matrices and induces serious adverse effects in various organs and tissues. Bone tissue seems to be a crucial target of Cd contamination. Macroautophagy/autophagy…

Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise Open

Xia Zhao, Zhujun Zhang, Bin Hu, Wei Huang, Chao Yuan , et al. · 2018

A few animal studies have shown that wheel running could reverse an unhealthy status by shifting the gut microbial composition, but no investigations have studied the effect of endurance running, such as marathon running, on human gut micr…

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells Open

Huifeng Pi, Min Li, Lingyun Zou, Min Yang, Ping Deng , et al. · 2018

Cadmium (Cd) is a toxic metal that is widely found in numerous environmental matrices and induces serious adverse effects in various organs and tissues. Bone tissue seems to be a crucial target of Cd contamination. Macroautophagy/autophagy…

Superficial vimentin mediates DENV-2 infection of vascular endothelial cells Open

Jie Yang, Lingyun Zou, Yi Yang, Jizhen Yuan, Zhen Hu , et al. · 2016

Multilocus Sequence Typing Analysis of Carbapenem-Resistant Acinetobacter baumannii in a Chinese Burns Institute Open

Guangtao Huang, Supeng Yin, Yali Gong, Xia Zhao, Lingyun Zou , et al. · 2016

Acinetobacter baumannii is a leading pathogen responsible for nosocomial infections. The emergence of carbapenem-resistant A. baumannii (CRAB) has left few effective antibiotics for clinicians to use. To investigate the tempo…

Ampelopsin Improves Insulin Resistance by Activating PPARγ and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway Open

Yong Zhou, Ying Wu, Yu Qin, Lei Liu, Jing Wan , et al. · 2016

Ampelopsin (APL), a major bioactive constituent of Ampelopsis grossedentata, exerts a number of biological effects. Here, we explored the anti-diabetic activity of APL and elucidate the underlying mechanism of this action. In palmitate-ind…

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