Lian Li
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View article: The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study
The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study Open
Social isolation and loneliness are independently associated with CF in Chinese older adults, highlighting the necessity of implementing effective and feasible interventions to concurrently address both factors in the prevention of CF amon…
View article: Characterization of vaginal microbiota across female reproductive phases
Characterization of vaginal microbiota across female reproductive phases Open
Background The vaginal microbiota plays a crucial role in women’s reproductive health, but its composition and function throughout different female reproductive phases remain poorly understood. This study aimed to investigate the dynamic v…
View article: Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort
Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort Open
Introduction Cervical carcinoma (CC) remains one of the significant cancers threatening women's health globally. Increasing evidence suggests that alterations in the microbiota are closely associated with cancer development. However, the u…
View article: Ningbo Schizophrenia Cohort (NSC)—a longitudinal ambispective cohort based on electronic health records: cohort profile
Ningbo Schizophrenia Cohort (NSC)—a longitudinal ambispective cohort based on electronic health records: cohort profile Open
Purpose Electronic health records (EHR) passively generate large datasets on real-world patient populations in easily retrievable form, allowing the cost-efficient and timely execution of epidemiological cohorts on a broad array of topics.…
View article: Associations of social isolation with sleep duration and sleep quality in the elderly: Mediating influence of depression
Associations of social isolation with sleep duration and sleep quality in the elderly: Mediating influence of depression Open
BACKGROUND Sleep disorders are common health problems in the elderly. The effect of social isolation on sleep duration and sleep quality remains unclear in the Chinese community-dwelling elderly. AIM To explore the associations of social i…
View article: Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications
Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications Open
Diabetes mellitus (DM) is a chronic metabolic disorder and one of the most significant global health burdens worldwide. Key pathophysiological mechanisms underlying its onset and associated complications include hyperglycemia-related stres…
View article: Improving Prognostic Value in Invasive Triple Negative Breast Cancer Through a Combined Nomogram Approach
Improving Prognostic Value in Invasive Triple Negative Breast Cancer Through a Combined Nomogram Approach Open
The incorporation of AJCC stage with US score, stromal TILs, and LVI improved the model performance for predicting poor outcomes in patients with invasive TNBC compared to routine AJCC staging alone.
View article: Successful aging was negatively associated with depression and anxiety symptoms among adults aged 65 years and older in Ningbo, China
Successful aging was negatively associated with depression and anxiety symptoms among adults aged 65 years and older in Ningbo, China Open
Background Depression and anxiety are the emotional problems most frequently experienced by older adults. We aimed to investigate the associations between successful aging (SA) and depression and anxiety in older adults from Ningbo, China.…
View article: Pectin supplementation accelerates post-antibiotic gut microbiome reconstitution orchestrated with reduced gut redox potential
Pectin supplementation accelerates post-antibiotic gut microbiome reconstitution orchestrated with reduced gut redox potential Open
Antibiotic-induced gut dysbiosis (AID) presents a big challenge to host health, and the recovery from this dysbiosis is often slow and incomplete. AID is typically characterized by elevation in redox potential, Enterobacteriaceae load, and…
View article: Effect of COVID-19 pandemic on serious mental illness-related outpatient department utilization in Ningbo, China: an interrupted time series analysis
Effect of COVID-19 pandemic on serious mental illness-related outpatient department utilization in Ningbo, China: an interrupted time series analysis Open
Background Globally, the coronavirus disease 2019 (COVID-19) pandemic has negatively affected mental health services, but there is no clear evidence of this in China. Therefore, we examined the effect of the COVID-19 pandemic on the use of…
View article: Immune-related adverse events of immune checkpoint inhibitors: a review
Immune-related adverse events of immune checkpoint inhibitors: a review Open
Since the first Immune Checkpoint Inhibitor was developed, tumor immunotherapy has entered a new era, and the response rate and survival rate of many cancers have also been improved. Despite the success of immune checkpoint inhibitors, res…
View article: Design and Application of Software Engineering Course Case Resource Library Based on Values Education through Curriculum
Design and Application of Software Engineering Course Case Resource Library Based on Values Education through Curriculum Open
In view of the immature construction of software engineering course case resource database in universities. This project presents a software engineering case library based on curriculum ideology and politics. An effective method to establi…
View article: Relationship Between the Early Initiation of Substance Use and Attempted Suicide Among in-School Adolescents in Seven Low- or Middle-Income African Countries: An Analysis of the Global School-Based Student Health Survey Data
Relationship Between the Early Initiation of Substance Use and Attempted Suicide Among in-School Adolescents in Seven Low- or Middle-Income African Countries: An Analysis of the Global School-Based Student Health Survey Data Open
Background: Preventing suicide among adolescents is an urgent global public-health challenge, especially in Africa. Accordingly, the aim of this study was to examine the relationship between the early initiation (< 12 years old) of subs…
View article: High S100A9+ cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection
High S100A9+ cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection Open
S100A9 is differentially expressed in various cell types and is associated with the development, progression and metastasis of various cancers. However, the expression, distribution, and clinical significance of S100A9 in hepatocellular ca…
View article: Additional file 2 of Ten years of China’s new healthcare reform: a longitudinal study on changes in health resources
Additional file 2 of Ten years of China’s new healthcare reform: a longitudinal study on changes in health resources Open
Additional file 2.
View article: Fast food consumption among young adolescents aged 12–15 years in 54 low- and middle-income countries
Fast food consumption among young adolescents aged 12–15 years in 54 low- and middle-income countries Open
The identified high prevalence of fast-food consumption among young adolescents in LMICs indicates the urgent need to prioritize the implementation of healthy-diet promotion programs to improve adolescent health in these countries.
View article: UFM1-Specific Ligase 1 Ligating Enzyme 1 Mediates Milk Protein and Fat Synthesis-Related Gene Expression via the JNK Signaling Pathway in Mouse Mammary Epithelial Cells
UFM1-Specific Ligase 1 Ligating Enzyme 1 Mediates Milk Protein and Fat Synthesis-Related Gene Expression via the JNK Signaling Pathway in Mouse Mammary Epithelial Cells Open
Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1) has been characterized as a ubiquitin-like (Ubl) protein that affects a range of cellular processes across various pathways. In this study, mouse mammary epithelial cells (HC11 cell line) …
View article: Physical behaviors of 12-15 year-old adolescents in 54 low- and middle-income countries: Results from the Global School-based Student Health Survey
Physical behaviors of 12-15 year-old adolescents in 54 low- and middle-income countries: Results from the Global School-based Student Health Survey Open
The prevalence of the separate physical behaviors and high levels of the combined physical behaviors was consistently low among young adolescents in LMICs, and that of all qualifying physical behaviors was even lower.
View article: Significant association between <i>DHFR</i> promoter methylation and ischemic stroke in a Chinese hypertensive population
Significant association between <i>DHFR</i> promoter methylation and ischemic stroke in a Chinese hypertensive population Open
Objective DHFR encodes dihydrofolate reductase, a major enzyme in the metabolism of folate, and is a candidate gene for ischemic stroke (IS). Therefore, we aimed to investigate the association between DHFR promoter methylation and IS in a …
View article: Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese Open
Our results demonstrated that DHFR promoter hypermethylation is positively associated with the risk of hypertension in Chinese.