Lin Liao
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View article: Unmasking Caregiver Heterogeneity: Latent Class Analysis of Abuse Tendency Subtypes for Alzheimer’s Disease Caregivers in China
Unmasking Caregiver Heterogeneity: Latent Class Analysis of Abuse Tendency Subtypes for Alzheimer’s Disease Caregivers in China Open
Background: Alzheimer's disease patients face higher risks of caregiver abuse and caregiver burden than healthy older adults,. However, the association between abuse tendency by AD caregivers and their burden remains understudied. This stu…
View article: Pure red-cell aplasia after radioactive iodine treatment in a patient with papillary thyroid cancer and follow up for two years: a case report
Pure red-cell aplasia after radioactive iodine treatment in a patient with papillary thyroid cancer and follow up for two years: a case report Open
Acquired pure red cell aplasia (PRCA) has attracted more and more attention in hematology. PRCA usually caused by infection, autoimmune diseases, thymic carcinoma, or drugs, has not been reported by radioactive iodine. Here we report a cas…
View article: Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder
Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder Open
Background Major depressive disorder (MDD) is associated with mitochondrial dysfunction and programmed cell death (PCD), though the underlying mechanisms remain unclear. This study aimed to investigate the molecular pathways involved in MD…
View article: A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial Virus
A Phase 2a, Randomized, Placebo-Controlled Human Challenge Trial to Evaluate the Efficacy and Safety of Molnupiravir in Healthy Participants Inoculated with Respiratory Syncytial Virus Open
View article: The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT
The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT Open
View article: Comparative Efficacy and Safety of Oral Semaglutide in Asians and Non-Asians Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Comparative Efficacy and Safety of Oral Semaglutide in Asians and Non-Asians Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
Oral semaglutide demonstrates superior efficacy in reducing HbA1c levels and a rapid onset of action in Asian patients. However, its efficacy appears to diminish with prolonged treatment in this population. Medium (7 mg)-dose oral semaglut…
View article: Multi-slice computed tomography radiomics combined with serum alpha-L-fucosidase: a potential biomarker for precise identification of pleomorphic adenoma and Warthin tumor
Multi-slice computed tomography radiomics combined with serum alpha-L-fucosidase: a potential biomarker for precise identification of pleomorphic adenoma and Warthin tumor Open
The optimized nomogram combining MSCT radiomics and AFU improved the accuracy of distinguishing PMA from WT, suggesting its potential for developing new biomarkers.
View article: <i>IPCEF1</i>: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma
<i>IPCEF1</i>: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma Open
Introduction: Despite the generally favorable prognosis of PTC (Papillary Thyroid Carcinoma), it can still exhibit aggressive behavior and lead to patient mortality. IPCEF1 (interaction protein for cytohesin exchange factors …
View article: 7347 The Efficacy And Safety Of Oral Semaglutide In Asian Patients With Type 2 Diabetes:A Systematic Review And Meta-Analysis
7347 The Efficacy And Safety Of Oral Semaglutide In Asian Patients With Type 2 Diabetes:A Systematic Review And Meta-Analysis Open
Disclosure: T. Wang: None. L. Liao: None. Objectives: To evaluate the efficacy and safety outcomes of oral semaglutide in Asian and non-Asian patients with type 2 diabetes mellitus(T2DM). Methods: Search several databases for randomized co…
View article: A multicenter retrospective study on comparing the efficacy and safety of the therapy of intermittent cyclophosphamide and corticosteroids versus rituximab for primary membranous nephropathy
A multicenter retrospective study on comparing the efficacy and safety of the therapy of intermittent cyclophosphamide and corticosteroids versus rituximab for primary membranous nephropathy Open
There was no difference in remission rates and safety between RTX versus intermittent intravenous CTX combined with oral corticosteroid treatment for patients with PMN within 2 years. RTX appeared to have benefits in terms of prolonging re…
View article: Correction to: Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Correction to: Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
View article: A New Ferroptosis-Related Long Non-Coding RNA Risk Model Predicts the Prognosis of Patients With Papillary Thyroid Cancer
A New Ferroptosis-Related Long Non-Coding RNA Risk Model Predicts the Prognosis of Patients With Papillary Thyroid Cancer Open
In summary, we identified a five-ferroptosis-related lncRNAs risk model to predict the prognosis of PTC. Furthermore, our study also revealed that LINC00900 functioned as a tumor suppressor lncRNA, LINC01614 and PARAL1 as an oncogenic lncR…
View article: Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients
Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients Open
Aims Rabson-Mendenhall syndrome (RMS) is a rare autosomal, recessive disorder characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. This study aims to analyze the clinical features and gene mutati…
View article: Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation
Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation Open
BSHX significantly reduced renal fibrosis and pyroptosis, and its mechanism was mainly associated with the inhibition of reactive oxygen species (ROS)/NLRP3-mediated inflammasome activation.
View article: Renal effects and safety between Asian and <scp>non‐Asian</scp> chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists
Renal effects and safety between Asian and <span>non‐Asian</span> chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists Open
Background Asians bear a heavier burden of chronic kidney disease (CKD), a common comorbidity of type 2 diabetes mellitus (T2DM), than non‐Asians. Nonsteroidal mineralocorticoid receptor antagonists (MRAs) have garnered attention for their…
View article: Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Comparative Efficacy and Safety of Tirzepatide in Asians and Non-Asians with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
PROSPERO registration no. CRD42023489588.
View article: High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad? Open
View article: Crosstalk between proximal tubular epithelial cells and other interstitial cells in tubulointerstitial fibrosis after renal injury
Crosstalk between proximal tubular epithelial cells and other interstitial cells in tubulointerstitial fibrosis after renal injury Open
The energy needs of tubular epithelial components, especially proximal tubular epithelial cells (PTECs), are high and they heavily depend on aerobic metabolism. As a result, they are particularly vulnerable to various injuries caused by fa…
View article: Claudin-2 Mediates the Proximal Tubular Epithelial Cell–Fibroblast Crosstalk via Paracrine CTGF
Claudin-2 Mediates the Proximal Tubular Epithelial Cell–Fibroblast Crosstalk via Paracrine CTGF Open
Our study suggested that Claudin-2 in PTECs, a key mediator of paracellular cation and water transport, promotes the activation and proliferation of surrounding fibroblasts significantly via CTGF in a paracrine manner.
View article: Three new compounds from the seeds of <i>Sinapis alba</i> L
Three new compounds from the seeds of <i>Sinapis alba</i> L Open
Three undescribed compounds, 1-(4-hydroxyphenyl)-3-((4-hydroxyphenyl)thio) −2-propanone (I), 4′-hydroxybenzyl 4-(4′′- hydroxybenzyloxy) benzyl thioether (II) and 3-(4′-hydroxybenzyl)-6-hydroxy-quinazolinone (III) were …
View article: Integration of ultrasound-based radiomics with clinical features for predicting cervical lymph node metastasis in postoperative patients with differentiated thyroid carcinoma
Integration of ultrasound-based radiomics with clinical features for predicting cervical lymph node metastasis in postoperative patients with differentiated thyroid carcinoma Open
Objective The primary objective was to establish a radiomics model utilizing longitudinal +cross-sectional ultrasound (US) images of lymph nodes (LNs) to predict cervical lymph node metastasis (CLNM) following differentiated thyroid carcin…
View article: A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity
A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity Open
Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. We evaluated the efficacy and safety of 24-week treatment of mazdutide up to 6 mg in Chinese overweight adults or adults with obesity, as an int…
View article: The association between serum selenium levels and pathological features of papillary thyroid cancer in 284 patients
The association between serum selenium levels and pathological features of papillary thyroid cancer in 284 patients Open
Objective The relationship between serum selenium levels and papillary thyroid cancer (PTC), especially the pathological features, still remains controversial. We conducted this study to investigate the relationship between serum selenium …
View article: Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma
Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma Open
Purpose Thyroid dysfunction is the most common immune-related adverse event during anti-programmed cell death 1 (anti-PD-1) therapy. In this study, we monitored patients with advanced malignant tumors who received anti-PD-1 therapy to obse…
View article: Research Progress of the Molecular Mechanism of Antithyroid Cancer Activityof Shikonin
Research Progress of the Molecular Mechanism of Antithyroid Cancer Activityof Shikonin Open
Thyroid cancer is one of the most common endocrine neoplasms. Treatment methods include surgical resection, radioactive iodine therapy, inhibition of thyroid-stimulating hormone, and inhibition of kinase-based target therapies. These treat…
View article: Effect of down-regulation of let-7c/g on triggering a double-negative feedback loop and promoting restenosis
Effect of down-regulation of let-7c/g on triggering a double-negative feedback loop and promoting restenosis Open
Background: Excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are the main causes of restenosis (RS) in diabetic lower extremity arterial disease (LEAD). However, the relevant pathogenic mechanisms are poorly un…
View article: Association between abnormal lipid metabolism and tumor
Association between abnormal lipid metabolism and tumor Open
Metabolic Reprogramming is a sign of tumor, and as one of the three major substances metabolism, lipid has an obvious impact. Abnormal lipid metabolism is related to the occurrence of various diseases, and the proportion of people with abn…
View article: Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma
Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma Open
Purpose Immune checkpoint inhibitors are associated with immune-related adverse events. Thyroid dysfunction during anti-programmed cell death 1(anti-PD-1) therapy remains to be fully characterized and mechanism underlying this complication…
View article: Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells
Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells Open
View article: Selenium and thyroid diseases
Selenium and thyroid diseases Open
Selenium, a non-metallic element, is a micronutrient essential for the biosynthesis of selenoproteins containing selenocysteine. In adults, the thyroid contains the highest amount of selenium per gram of tissue. Most known selenoproteins, …