Linhai Chen
YOU?
Author Swipe
View article: Biomimetic Total Synthesis of Dispirocochlearoids A–C and Related <i>Ganoderma</i> Meroterpenoid Dimers
Biomimetic Total Synthesis of Dispirocochlearoids A–C and Related <i>Ganoderma</i> Meroterpenoid Dimers Open
The first total synthesis of the anti-inflammatory Ganoderma meroterpenoid dimers dispirocochlearoids A-C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that …
View article: Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging
Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging Open
GPR84 is a promising therapeutic target and biomarker for a range of diseases. In this study, we reported the discovery of BINOL phosphate (BINOP) derivatives as GPR84 antagonists. By investigating the structure-activity relationship, we i…
View article: Improved Lymphangiogenesis around Vascularized Lymph Node Flaps by Periodic Injection of Hyaluronidase in a Rodent Model
Improved Lymphangiogenesis around Vascularized Lymph Node Flaps by Periodic Injection of Hyaluronidase in a Rodent Model Open
Background Vascularized lymph node transfer (VLNT) is an advanced surgical approach for secondary lymphedema (SLE) treatment, but tissue fibrosis around the lymph node flap (VLNF) inhibiting lymphangiogenesis is the biggest challenge under…
View article: Anatomy and relationships of forelimb lymph nodes in Sprague-Dawley rats: A detailed dissecting approach
Anatomy and relationships of forelimb lymph nodes in Sprague-Dawley rats: A detailed dissecting approach Open
Background Constructing a reliable animal model for preclinical treatment of secondary lymphedema is challenging because the anatomical characteristics near the lymph nodes are understudied. Therefore, this study examined the detailed anat…
View article: <scp>Protecting‐Group‐Free One‐Step Palladium‐Catalyzed</scp> Coupling on <scp>C25</scp> of Cucurbitacin B Expands Chemical Diversity with Improved Cytotoxicity against <scp>A549</scp> Cells
<span>Protecting‐Group‐Free One‐Step Palladium‐Catalyzed</span> Coupling on <span>C25</span> of Cucurbitacin B Expands Chemical Diversity with Improved Cytotoxicity against <span>A549</span> Cells Open
Comprehensive Summary The natural product cucurbitacin B has been widely studied because of its multiple biological activities, especially its potent antitumor effects. However, modifications of cucurbitacin B are mainly focused on the C2 …
View article: Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis
Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis Open
GPR84 is a proinflammatory G protein-coupled receptor associated with several inflammatory and fibrotic diseases. GPR84 antagonists have been evaluated in clinical trials to treat ulcerative colitis, idiopathic pulmonary fibrosis, and nona…
View article: High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist
High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist Open
Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are mainly expressed in the brain with important roles in the regulation of appetite, en…
View article: Identification of key candidate genes in local dorsal root ganglion inflammation by integrated bioinformatics analysis
Identification of key candidate genes in local dorsal root ganglion inflammation by integrated bioinformatics analysis Open
The purpose of the present study was to identify potential markers of local dorsal root ganglion (DRG) inflammation to aid diagnosis, treatment and prognosis evaluation of DRG pain. A localized inflammation of the DRG (LID) rat model was u…
View article: Strigolactone mimic 2‐nitrodebranone is highly active in Arabidopsis growth and development
Strigolactone mimic 2‐nitrodebranone is highly active in Arabidopsis growth and development Open
SUMMARY Strigolactones play crucial roles in regulating plant architecture and development, as endogenous hormones, and orchestrating symbiotic interactions with fungi and parasitic plants, as components of root exudates. rac ‐GR24 is curr…
View article: Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists
Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists Open
Since the discovery of medium-chain fatty acids as GPR84 ligands, significant advancements have been made in the development of GPR84 agonists and antagonists. Most agonists have lipid-like structures except for 3,3'-diindolylmethane (DIM)…
View article: Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of <i>Staphylococcus aureus</i>
Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is a prevalent bacterial pathogen in both community and hospital settings, and its treatment is made particularly difficult by resilience within biofilms. Within this niche, serine hydrolase enzymes play a key role in…
View article: Structural basis for active-site probes targeting<i>Staphylococcus aureus</i>serine hydrolase virulence factors
Structural basis for active-site probes targeting<i>Staphylococcus aureus</i>serine hydrolase virulence factors Open
Summary Staphylococcus aureus is a major cause of infection in the community and in hospitals. Serine hydrolases play key roles in bacterial homeostasis, in particular biofilms. Activity-based profiling has previously identified a family o…
View article: The character and design of LCC resonant converter for constant current applications
The character and design of LCC resonant converter for constant current applications Open
LCC resonant converter has a good feature of constant current characteristics, which is the ideal driver for medium and high-power LED lighting. In this paper, based on a LCC resonant converter characteristic that the transformer primary s…
View article: Uncertainty in Upscaling In Situ Soil Moisture Observations to Multiscale Pixel Estimations with Kriging at the Field Level
Uncertainty in Upscaling In Situ Soil Moisture Observations to Multiscale Pixel Estimations with Kriging at the Field Level Open
Upscaling in situ soil moisture observations (ISMO) to multiscale pixel estimations with kriging is a key step in the comprehensive usage of ISMO and remote sensing (RS) soil moisture data. Scale effects occur and introduce uncertainties d…
View article: Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists
Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists Open
A series of alkylpyrimidine-4,6-diol derivatives were designed and synthesized as novel GRP84 agonists based on a high-throughput screening (HTS) hit 1. 6-Nonylpyridine-2,4-diol was identified as the most potent agonist of GPR84 reported s…