Qian Li
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View article: GPTAnno: Ontology-tree-guided hierarchical cell type annotation based on GPT models for single-cell data
GPTAnno: Ontology-tree-guided hierarchical cell type annotation based on GPT models for single-cell data Open
Cell type annotation is critical for interpreting single-cell transcriptomic data but remains challenging due to uncertain cellular clustering granularity and inconsistent labeling across studies. Here we present GPTAnno, an automated, ont…
View article: Epidemiological Analysis of Female Menopausal Syndrome and Exploration of Cognitive Levels Regarding Hormone Replacement Therapy
Epidemiological Analysis of Female Menopausal Syndrome and Exploration of Cognitive Levels Regarding Hormone Replacement Therapy Open
Objective: To investigate and statistically analyze the prevalence of female menopausal syndrome, while assessing their understanding of hormone replacement therapy (HRT). Methods: A total of 3,200 women who visited Huangpu District Matern…
View article: A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent <i>Klebsiella pneumoniae</i>
A novel tail fiber protein triggers phage DNA ejection by recognizing lipopolysaccharides of K54 hypervirulent <i>Klebsiella pneumoniae</i> Open
Bacteriophage (phage) therapy is a promising alternative antibacterial approach for treating infectious diseases by hv Kp . However, there has been a lack of studies on the host recognition and infection initiation of hv Kp phages. In this…
View article: Revisiting cardiac regeneration: the role of remote heart regions after MI
Revisiting cardiac regeneration: the role of remote heart regions after MI Open
View article: Multicenter study on CT-based Radiomics for predicting severity and delayed recovery in Mycoplasma pneumoniae pneumonia
Multicenter study on CT-based Radiomics for predicting severity and delayed recovery in Mycoplasma pneumoniae pneumonia Open
Objective To develop and validate model based on clinical, imaging, and Radiomics features for predicting disease severity and delayed recovery in Mycoplasma pneumoniae pneumonia (MPP). Methods This multicenter retrospective study enrolled…
View article: CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis
CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis Open
View article: TRIM35, a novel DNA-binding protein, epigenetically modifies H3 to promote HSPA6 transcription and suppress breast cancer progression
TRIM35, a novel DNA-binding protein, epigenetically modifies H3 to promote HSPA6 transcription and suppress breast cancer progression Open
Tripartite Motif Containing 35 (TRIM35) is a well-characterized ubiquitin ligase with established roles in antiviral immunity, cancer metabolism, cardiovascular function, and tumor progression. However, its function as a DNA-binding protei…
View article: Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes
Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes Open
AIMS: The precise cellular identity and molecular features of non-myocytes (non-CMs) in a mammalian heart at a single-cell level remain elusive. Depiction of epigenetic landscape with transcriptomic signatures using the latest single-cell …
View article: iSMNN: batch effect correction for single-cell RNA-seq data via iterative supervised mutual nearest neighbor refinement
iSMNN: batch effect correction for single-cell RNA-seq data via iterative supervised mutual nearest neighbor refinement Open
Batch effect correction is an essential step in the integrative analysis of multiple single-cell RNA-sequencing (scRNA-seq) data. One state-of-the-art strategy for batch effect correction is via unsupervised or supervised detection of mutu…
View article: Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration Open
View article: Ultra-late relapse of acute promyelocytic leukemia 18 years after complete remission: a case report and literature review
Ultra-late relapse of acute promyelocytic leukemia 18 years after complete remission: a case report and literature review Open
Late relapse of acute promyelocytic leukemia (APL) is associated with high mortality rates. While APL typically shows a low incidence of relapse after achieving complete remission (CR) for more than 7 years, we report a rare case of APL re…
View article: Power and sample size for reversible linear mixed models with clustering and longitudinality: GLIMMPSE Version 3
Power and sample size for reversible linear mixed models with clustering and longitudinality: GLIMMPSE Version 3 Open
GLIMMPSE Version 3 is a free, web-based, open-source software tool, which calculates power and sample size for general linear mixed models with Gaussian errors. The software permits power calculations for clinical trials, randomized experi…
View article: Cost-effectiveness of polatuzumab vedotin plus chemoimmunotherapy for untreated diffuse large B-cell lymphoma in China
Cost-effectiveness of polatuzumab vedotin plus chemoimmunotherapy for untreated diffuse large B-cell lymphoma in China Open
View article: Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report
Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report Open
Background Microcystic meningioma (MM) is a distinctive benign tumor typically located in the supratentorial region. Giant cell reparative granuloma (GCRG) is another rare reactive benign lesion associated with surgical trauma or tissue in…
View article: Differential expression pattern of CC chemokine receptor 7 guides precision treatment of hepatocellular carcinoma
Differential expression pattern of CC chemokine receptor 7 guides precision treatment of hepatocellular carcinoma Open
The treatment of hepatocellular carcinoma (HCC) faces challenges of low response rates to targeted drugs and immune checkpoint inhibitors, which are influenced by complicated microenvironment of HCC. In this study, the complex tumor microe…
View article: Deficits in mitochondrial dynamics and iron balance result in templated insertions
Deficits in mitochondrial dynamics and iron balance result in templated insertions Open
View article: Characterization and Therapeutic Potential of Three Depolymerases Against K54 Capsular-Type Klebsiella pneumoniae
Characterization and Therapeutic Potential of Three Depolymerases Against K54 Capsular-Type Klebsiella pneumoniae Open
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp), a pathogen causing severe nosocomial infections and high mortality rates, is increasingly becoming a serious global public health threat. Capsular polysaccharide (CPS), a …
View article: Insights into Cripto-1 as a target for cancer diagnosis and treatment: A mini-review
Insights into Cripto-1 as a target for cancer diagnosis and treatment: A mini-review Open
Cripto-1, a glycoprotein and key member of the epidermal growth factor-Cripto-1-FRL-1-Cryptic family, has garnered significant attention in cancer research due to its dual roles in embryonic development and tumor progression. The central r…
View article: Nr4a1 modulates inflammation and heart regeneration in zebrafish
Nr4a1 modulates inflammation and heart regeneration in zebrafish Open
Recent findings have highlighted the complex role of inflammation in zebrafish heart regeneration, demonstrating that although inflammation is essential for initiating transient fibrosis and tissue repair, chronic inflammation, and unresol…
View article: A Near‐Infrared Fluorescence Hypochlorite Probe for Imaging Atherosclerosis without Interference from Serum Protein and Microenvironment Factors
A Near‐Infrared Fluorescence Hypochlorite Probe for Imaging Atherosclerosis without Interference from Serum Protein and Microenvironment Factors Open
Comprehensive Summary Atherosclerosis (AS), a chronic vascular lesion, constitutes the primary pathological basis for a variety of cardiovascular diseases that account for 85% of total cardiovascular mortality. The accurate identification …
View article: Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes
Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes Open
Background and Aims Visceral pain is a cardinal symptom of many disorders affecting the gut. Modulators of gamma-aminobutyric acid (GABA) such as benzodiazepines may attenuate colonic pain but the specific contribution of peripheral GABAA …
View article: OP0299 GENAKUMAB REDUCES THE RISK OF ACUTE GOUT FLARES DURING INITIATION OF URATE-LOWERING THERAPY: A PHASE 2, RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED CLINICAL TRIAL
OP0299 GENAKUMAB REDUCES THE RISK OF ACUTE GOUT FLARES DURING INITIATION OF URATE-LOWERING THERAPY: A PHASE 2, RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED CLINICAL TRIAL Open
View article: POS1166 EFFICACY AND SAFETY OF GENAKUMAB FOR FIRST-LINE TREATMENT OF GOUT FLARE: A PHASE 2, MULTICENTER, OPEN-LABEL, ACTIVE CONTROLLED, RANDOMIZED NON-INFERIORITY TRIAL
POS1166 EFFICACY AND SAFETY OF GENAKUMAB FOR FIRST-LINE TREATMENT OF GOUT FLARE: A PHASE 2, MULTICENTER, OPEN-LABEL, ACTIVE CONTROLLED, RANDOMIZED NON-INFERIORITY TRIAL Open
View article: Robust Accessibility of Addressable Sites in Defective DNA Origami
Robust Accessibility of Addressable Sites in Defective DNA Origami Open
Owing to its unique programmability and addressability, DNA origami-based nanofabrication has been widely utilized in fields such as nanomedicine and nanophotonics. The accessibility of addressable sites on DNA origami structures is crucia…
View article: Comprehensive analysis through multi-omics integration to compare and elucidate the specific substances in milk of donkey、horse、camel、human and pig
Comprehensive analysis through multi-omics integration to compare and elucidate the specific substances in milk of donkey、horse、camel、human and pig Open
View article: Genetic and Antiviral Potential Characterization of Four Insect-Specific Viruses Identified and Isolated from Mosquitoes in Yunnan Province
Genetic and Antiviral Potential Characterization of Four Insect-Specific Viruses Identified and Isolated from Mosquitoes in Yunnan Province Open
Mosquitoes, comprising over 300 species, are pivotal vectors for transmitting arthropod-borne viruses (arboviruses) to vertebrates via bites, posing a significant public health threat with approximately 700,000 annual deaths. In contrast, …
View article: Charting Postnatal Heart Development Using <i>In Vivo</i> Single-Cell Functional Genomics
Charting Postnatal Heart Development Using <i>In Vivo</i> Single-Cell Functional Genomics Open
The transition at birth, marked by increased circulatory demands and rapid growth, necessitates extensive remodeling of the heart’s structure, function, and metabolism. This transformation requires precise spatial and temporal coordination…
View article: Empowering Mandarin Speaking Skills: High School Students’ Journey with Mobile-Flipped Learning
Empowering Mandarin Speaking Skills: High School Students’ Journey with Mobile-Flipped Learning Open
In the post-pandemic era, the framework of distance education and online teaching has blazed a new trail in the educational landscape. Simultaneously, in the current transformation of the educational paradigm, flipped learning has gained r…
View article: Analysis of rabbiteye blueberry metabolomes and transcriptomes reveals mechanisms underlying potassium-induced anthocyanin production
Analysis of rabbiteye blueberry metabolomes and transcriptomes reveals mechanisms underlying potassium-induced anthocyanin production Open
Environmental factors play an important role in anthocyanin biosynthesis, and potassium, an essential nutrient for blueberry growth, can act as an enzyme activator. However, few reports exist on the transcriptional and anthocyanin metaboli…
View article: LncRNA XIST Promotes Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma Cells<i>via</i>Regulation of miR-186-5p/ZEB1
LncRNA XIST Promotes Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma Cells<i>via</i>Regulation of miR-186-5p/ZEB1 Open
Our data revealed that lncRNA XIST promotes ESCC metastasis by regulating the miR-186-5p/ZEB1 axis. This study may provide a theoretical basis for the molecular mechanisms involved in esophageal cancer.