Linhong Deng
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View article: Comparison of Illumina NovaSeq 6000 and GeneMind SURFSeq 5000 platforms for single‐cell spatial transcriptomics of mouse brain and lung
Comparison of Illumina NovaSeq 6000 and GeneMind SURFSeq 5000 platforms for single‐cell spatial transcriptomics of mouse brain and lung Open
Single‐cell spatial transcriptomics enables comprehensive gene expression profiling with precise cellular localization within tissue architecture. To systematically evaluate the compatibility and performance of alternative sequencing platf…
View article: Airway Mucus Rheology: Physical Insights for Navigating through Health to Pathology and Clinical Applications
Airway Mucus Rheology: Physical Insights for Navigating through Health to Pathology and Clinical Applications Open
Airway mucus is a complex gel with an anisotropic three-dimensional network structure. As a crucial component of the respiratory defense barrier, it plays a vital role in maintaining airway hydration and supporting the function of airway e…
View article: Mechanism of Carbon Diffusion and Phase‐Transition‐Induced FCC‐TiC Formation via Hot Pressing
Mechanism of Carbon Diffusion and Phase‐Transition‐Induced FCC‐TiC Formation via Hot Pressing Open
Titanium carbide (TiC), which typically forms at the solid‐state diffusion interface in steel–titanium (Ti) composite structures, significantly influences steel–Ti interface bonding. However, the atomic‐level formation mechanism of this ca…
View article: Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics
Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics Open
View article: CAF-Driven Mechanotransduction via Collagen Remodeling Accelerates Tumor Cell Cycle Progression
CAF-Driven Mechanotransduction via Collagen Remodeling Accelerates Tumor Cell Cycle Progression Open
Cancer-associated fibroblasts (CAFs) restructure collagen hydrogels via actomyosin-driven fibril bundling and crosslinking, increasing polymer density to generate mechanical stress that accelerates tumor proliferation. Conventional hydroge…
View article: The Effect of Integrative Neuromuscular Training on Enhancing Athletic Performance: A Systematic Review and Meta-Analysis
The Effect of Integrative Neuromuscular Training on Enhancing Athletic Performance: A Systematic Review and Meta-Analysis Open
Purpose: Integrated neuromuscular training (INT) is a multidimensional training method that integrates strength, balance, core stability, flexibility, and motor skill development. The aim of this study was to systematically evaluate the ef…
View article: 0060 CGRP-ramp1 signaling tunes memory CD8 T cell responses through langerhans cells
0060 CGRP-ramp1 signaling tunes memory CD8 T cell responses through langerhans cells Open
View article: Clinical features, disease burden and impact on quality of life in participants with mitochondrial encephalomyopathy
Clinical features, disease burden and impact on quality of life in participants with mitochondrial encephalomyopathy Open
Background Mitochondrial encephalomyopathy (ME) is a rare genetic disorder that significantly impacts participants’ quality of life and places emotional and financial burdens on caregivers. However, the dynamics between perceived financial…
View article: Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models Open
Background Pain serves as a vital protective mechanism triggered by tissue damage. While NSAIDs and opioids offer relief, their prolonged usage is hindered by adverse effects. Developing analgesics with fewer side effects is crucial for ef…
View article: Effectiveness of enhanced recovery after surgery in elderly patients undergoing total hip arthroplasty
Effectiveness of enhanced recovery after surgery in elderly patients undergoing total hip arthroplasty Open
View article: Deficiency of integrin β4 contributes bronchopulmonary dysplasia by compromising cellular stability through the activation of RhoA-(ZO-1) signaling pathways
Deficiency of integrin β4 contributes bronchopulmonary dysplasia by compromising cellular stability through the activation of RhoA-(ZO-1) signaling pathways Open
Alterations in the composition and remodeling of the lung extracellular matrix (ECM) are critical for lung development. Our research identified that mice with a conditional knockout of integrin β4 (Itgb4) exhibit lung dysplasia. In this st…
View article: Fe2O3 nanoparticles disrupt microstructure and reduce the viscoelasticity of simulated asthma airway mucus for potential airway mucus clearance applications
Fe2O3 nanoparticles disrupt microstructure and reduce the viscoelasticity of simulated asthma airway mucus for potential airway mucus clearance applications Open
Fe 2 O 3 nanoparticles have been developed as carriers to transport drugs through airway mucus (AM); however, their impacts on the rheological properties of AM, especially in disease states, are unknown. In this study, we investigated the …
View article: Identification of genes associated with liver ischemia-reperfusion injury after liver transplantation by WGCNA and PPI network analyses
Identification of genes associated with liver ischemia-reperfusion injury after liver transplantation by WGCNA and PPI network analyses Open
Liver transplantation is the only effective treatment for end-stage liver disease. The success of transplantation largely relies on liver ischemia/reperfusion injury (LIRI). However, the pathogenesis of LIRI remains unclear. In this study,…
View article: Mechanical Behavior and Indentation-Induced Injury of Soft Microtissues with Different Densification Levels
Mechanical Behavior and Indentation-Induced Injury of Soft Microtissues with Different Densification Levels Open
Tissue densification is a fundamental biological process involved in development, regeneration, and disease, significantly influencing tissue mechanics and cellular mechanical microenvironments. However, the effects of tissue densification…
View article: FRET imaging of Piezo1–calcium signal activation induced by chemical agonist and microfluidic shear forces
FRET imaging of Piezo1–calcium signal activation induced by chemical agonist and microfluidic shear forces Open
The discovery of Piezo channels has advanced the understanding of mechanobiology, which acts as mechanosensitive cation channels in sensing mechanical stimuli and regulating various physiological functions. Despite the electrophysiological…
View article: Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025)
Spatial Transcriptomics: Biotechnologies, Computational Tools, and Neuroscience Applications (Small Methods 5/2025) Open
View article: [Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials].
[Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials]. Open
The evaluation of blood compatibility of biomaterials is crucial for ensuring the clinical safety of implantable medical devices. To address the limitations of traditional testing methods in real-time monitoring and electrical property ana…
View article: A retrospective study of insurance coverage status and economic cost of rare diseases in Hainan Province
A retrospective study of insurance coverage status and economic cost of rare diseases in Hainan Province Open
View article: FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force
FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force Open
von Willebrand factor (vWF) is a large glycoprotein in the circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets in assembling clots. How vWF mechanosenses shear flow for molecular unfolding i…
View article: Precise Characterization of Cellular States and Spatial Variable Patterns within Spatial Transcriptomics
Precise Characterization of Cellular States and Spatial Variable Patterns within Spatial Transcriptomics Open
Spatial transcriptomics enables the simultaneous characterization of gene expression and spatial organization, providing transformative insights into tissue architecture and function. While numerous tools have been developed to identify sp…
View article: Evaluating the feasibility, safety and efficacy of accelerated continuous theta-burst stimulation targeting the left primary motor cortex to improve social communication impairment in children with autism
Evaluating the feasibility, safety and efficacy of accelerated continuous theta-burst stimulation targeting the left primary motor cortex to improve social communication impairment in children with autism Open
View article: Efficient sampling of conformational space via unbiased molecular dynamics in multiple low-dimensional collective variable spaces
Efficient sampling of conformational space via unbiased molecular dynamics in multiple low-dimensional collective variable spaces Open
Molecular dynamics (MD) simulations struggle to resolve rare conformational transitions hindered by high energy barriers. We introduce the Equivalent Weight Method (EWM), an enhanced sampling framework that combines dynamic trajectory segm…
View article: The impact of rare diseases on the quality of life in paediatric patients: current status
The impact of rare diseases on the quality of life in paediatric patients: current status Open
Rare diseases, also known as orphan diseases, are a group of disorders that affect a small percentage of the population. Despite individually affecting a small number of people, collectively, they impact millions worldwide. This is particu…
View article: Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages
Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages Open
Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to d…
View article: Effectiveness of an mHealth- and School-Based Health Education Program for Salt Reduction (EduSaltS) in China: Cluster Randomized Controlled Trial Within Scale-Up
Effectiveness of an mHealth- and School-Based Health Education Program for Salt Reduction (EduSaltS) in China: Cluster Randomized Controlled Trial Within Scale-Up Open
Background Globally, cardiovascular diseases are leading causes of mortality and disability, with hypertension being a major risk factor. Reducing salt intake and blood pressure are among the most cost-effective health promotion strategies…
View article: Impact of Altitude Training on Athletes’ Aerobic Capacity: A Systematic Review and Meta-Analysis
Impact of Altitude Training on Athletes’ Aerobic Capacity: A Systematic Review and Meta-Analysis Open
Purpose: This study systematically evaluated the effects of altitude training on athletes’ aerobic capacity, focusing on optimal training modalities and intervention durations. Methods: Eight databases (CNKI, CSPD, PubMed, Ovid Medline, Pr…
View article: FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force
FRET Visualization of High Mechanosensation of von Willebrand Factor to Hydrodynamic Force Open
von Willebrand factor (vWF) is a large glycoprotein in circulation system, which senses hydrodynamic force at vascular injuries and then recruits platelets in assembling clots. How vWF mechanosenses shear flow for molecular unfolding is an…
View article: Clinical Features, Disease Burden and Impact on Quality of Life in Patients with Mitochondrial Encephalomyopathy
Clinical Features, Disease Burden and Impact on Quality of Life in Patients with Mitochondrial Encephalomyopathy Open
Background Mitochondrial encephalomyopathy (ME) significantly impacts patient quality of life (QoL) and imposes burdens on caregivers. This study examined disease burden, financial strain, QoL, disability levels, and caregiver burden among…
View article: The underlying difference of metastatic and non-metastatic breast cancer cells in configuring type I collagen fibres to promote migration by cell mechanics
The underlying difference of metastatic and non-metastatic breast cancer cells in configuring type I collagen fibres to promote migration by cell mechanics Open
View article: Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy
Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy Open