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<span>ZSF1</span> lean rats – How healthy are they? Open
ZSF1 lean rats are widely used as controls in cardiometabolic studies involving ZSF1 obese rats, which develop a cardiometabolic syndrome and diastolic dysfunction at a young age due to a double leptin receptor mutation (Lepr cp and Lepr f…
View article: Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement
Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement Open
Importance Aortic stenosis (AS) and obstructive coronary artery disease (CAD) often coexist, yet the impact of obstructive CAD on clinical and patient-reported outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) r…
View article: Fully Automatic AI-Based Quantification of LV Mass in Echocardiography
Fully Automatic AI-Based Quantification of LV Mass in Echocardiography Open
AI echocardiography provides superior accuracy, diagnostic performance, and reproducibility for LV mass assessment compared with expert evaluation, supporting its clinical integration to improve standardization in cardiac imaging.
View article: Impact of diabetes on outcomes of patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease undergoing percutaneous coronary intervention
Impact of diabetes on outcomes of patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease undergoing percutaneous coronary intervention Open
Background Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presentin…
View article: Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock Open
Importance Microaxial flow pump treatment improves survival in selected patients with infarct-related cardiogenic shock; however, treatment carries substantial risks, and benefit may vary by patient subgroup. Systolic blood pressure (SBP) …
View article: Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut THVs: insights from LANDMARK trial
Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut THVs: insights from LANDMARK trial Open
Aims Several factors, including device design, annulus size, and sizing strategies, influence transcatheter heart valve (THV) haemodynamic outcomes in patients with aortic stenosis (AS). This sub-study evaluates early (30-day) echocardiogr…
Fusion of automatically learned rhythm and morphology features matches diagnostic criteria and enhances AI explainability Open
Deep learning (DL) has demonstrated high accuracy in ECG analysis but lacks in explainability. Although explanations can be estimated using explainable artificial intelligence, their causality has not yet been sufficiently investigated. We…
View article: Transcatheter mitral repair in patients with symptomatic moderate functional mitral regurgitation: 1-year outcomes from the MiCLASP study
Transcatheter mitral repair in patients with symptomatic moderate functional mitral regurgitation: 1-year outcomes from the MiCLASP study Open
In the MiCLASP study, patients with moderate FMR experienced significant MR reduction at 1 year, resulting in clinical and symptomatic benefits comparable to those with ≥moderate-severe FMR, suggesting that select patients with symptomatic…
View article: The ‘Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal Derived Phenotypes Synthesis’ project: conceptual design, project planning, and first implementation experiences
The ‘Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal Derived Phenotypes Synthesis’ project: conceptual design, project planning, and first implementation experiences Open
Aims Personalized risk assessment tools (PRTs) are recommended by cardiovascular guidelines to tailor prevention, diagnosis, and treatment. However, PRT implementation in clinical routine is poor. ACRIBiS (Advancing Cardiovascular Risk Ide…
View article: Clinical and health status after permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement: Insights from the SCOPE I randomized trial
Clinical and health status after permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement: Insights from the SCOPE I randomized trial Open
In the SCOPE I trial, new PPM implantation complicating TAVR had no impact on an integrated endpoint of vital and disease-specific health status throughout 3 years of follow-up.
View article: Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study
Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study Open
Aims Heart failure–related cardiogenic shock (HF‐CS) accounts for about half of CS cases, with a paucity of data regarding the role of kidney injury in this subset. This study aims to evaluate patient characteristics and outcome associated…
View article: Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation
Transcatheter Edge-to-Edge Repair in Patients With Primary Tricuspid Regurgitation Open
TEER is a safe and effective option for primary TR, promoting right heart reverse remodeling and symptomatic relief, offering a vital alternative to surgery in selected patients.
Management and outcome of different types of ventricular tachycardia related to hypokalemia Open
Background Hypokalemia is a potentially reversible cause of ventricular tachyarrhythmias (VTs) such as polymorphic ventricular tachycardia/ventricular fibrillation (PMVT/VF) and sustained monomorphic ventricular tachycardia (SMVT). Despite…
View article: Complete revascularization versus culprit-lesion only PCI in patients with NSTEMI and multivessel disease – Design and rationale of the randomized COMPLETE-NSTEMI trial
Complete revascularization versus culprit-lesion only PCI in patients with NSTEMI and multivessel disease – Design and rationale of the randomized COMPLETE-NSTEMI trial Open
CLINICALTRIALS.GOV: NCT05786131.
View article: Different Mechanical Circulatory Support Strategies for Infarct-Related Cardiogenic Shock
Different Mechanical Circulatory Support Strategies for Infarct-Related Cardiogenic Shock Open
Bailout and escalated MCS therapy is associated with numerically higher 30-day mortality compared with upfront ECLS use only. Bailout MCS use is also associated with higher need for renal replacement therapy. (Extracorporeal Life Support i…
The Impact of Frailty on VARC-3 Integrated Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement Open
More than 1 in 6 patients with severe aortic stenosis undergoing TAVR were considered frail in the SCOPE I trial. Patients with frailty had a similar improvement in patient-reported health status measures after TAVR, but a higher risk of u…
View article: Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial
Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial Open
Patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) have a substantially increased risk for major cardiovascular events and mortality. Increasing physical activity and improving a healthy diet may effectively red…
View article: Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF
Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF Open
Background Cardiac myosin binding protein C (cMyC) is an emerging new biomarker of myocardial injury rising earlier and cleared faster than cardiac troponins. It has discriminatory power similar to high‐sensitive troponins in diagnosing my…
View article: Early outcomes of the novel Myval THV series compared to SAPIEN THV series and Evolut THV series in individuals with severe aortic stenosis
Early outcomes of the novel Myval THV series compared to SAPIEN THV series and Evolut THV series in individuals with severe aortic stenosis Open
ClinicalTrials.gov: NCT04275726; EudraCT number 2020-000,137-40.
View article: Cerebral Embolic Protection by Geographic Region
Cerebral Embolic Protection by Geographic Region Open
Importance Transcatheter aortic valve replacement (TAVR) is an established treatment option for many patients with severe symptomatic aortic stenosis; however, debris dislodged during the procedure can cause embolic stroke. The Sentinel ce…
View article: Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial
Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial Open
BACKGROUND: In DanGer Shock (the Danish–German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment–elevation myocardial infarction–related cardiogenic shock led to lower all-cause mortality but higher…
View article: Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic Shock
Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic Shock Open
Importance Mechanical circulatory support with a microaxial flow pump (MAFP) has been shown to improve survival in ST-elevation myocardial infarction–induced cardiogenic shock (STEMI-CS). Understanding the impact on hemodynamic stability o…
View article: Sex-Related Differences in Outcome of Patients Treated With Microaxial Percutaneous Left Ventricular Assist Device for Cardiogenic Shock
Sex-Related Differences in Outcome of Patients Treated With Microaxial Percutaneous Left Ventricular Assist Device for Cardiogenic Shock Open
This study showed no differences in all-cause mortality at 30 days between male and female patients receiving microaxial pLVAD in CS. Larger studies are required to confirm whether female sex is associated with reduced requirement of RRT i…
View article: The role of artificial intelligence in standardizing global longitudinal strain measurements in echocardiography
The role of artificial intelligence in standardizing global longitudinal strain measurements in echocardiography Open
Aims To evaluate the accuracy and feasibility of artificial intelligence (AI) in left ventricular global longitudinal strain (GLS) analysis as compared to conventional (Manual) and semi-automated (SemiAuto) method in echocardiography (Echo…
View article: Global longitudinal strain measurement in the modern era - is artificial intelligence the answer ?
Global longitudinal strain measurement in the modern era - is artificial intelligence the answer ? Open
Background Global longitudinal strain (GLS) enhances the assessment of left ventricular (LV) function beyond ejection fraction (EF) in 2D echocardiography (Echo). However, manual GLS measurement, the most common technique, is operator depe…
View article: Prognostic Impact of Admission Time in Infarct-Related Cardiogenic Shock
Prognostic Impact of Admission Time in Infarct-Related Cardiogenic Shock Open
The prognosis in AMI-CS was not affected by admission time with a similar effect of ECLS during on- and off-hours.