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View article: FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway
FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway Open
Tauopathies are a group of neurodegenerative disorders characterized by hyperphosphorylation and aggregation of the Tau protein. The Fragile X Messenger Ribonucleoprotein 1 (FMRP) is an RNA-binding protein known to regulate the translation…
View article: O-GlcNAcase promotes dendritic spine morphogenesis while downregulating their GluA2-containing AMPA receptors
O-GlcNAcase promotes dendritic spine morphogenesis while downregulating their GluA2-containing AMPA receptors Open
Dendritic spines are essential for synaptic transmission, neural circuit organization, and cognitive function. Their morphology and density influence synaptic plasticity, learning, and memory. Many proteins in dendritic spines are modified…
View article: Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits
Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits Open
Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. …
View article: Microglial <i>Tmem59</i> Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice
Microglial <i>Tmem59</i> Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice Open
Synaptic abnormality is an important pathologic feature of autism spectrum disorders (ASDs) and responsible for various behavioral defects in these neurodevelopmental disorders. Microglia are the major immune cells in the brain and also pl…
View article: Kron Reduction Based on Node Ordering Optimization for Distribution Network Dispatching with Flexible Loads
Kron Reduction Based on Node Ordering Optimization for Distribution Network Dispatching with Flexible Loads Open
Kron reduction is a general tool of network simplification for flow calculation. With a growing number of flexible loads appearing in distribution networks, traditional Kron reduction cannot be widely used in control and scheduling due to …
View article: The Morality Impact of Price War and Low Salary on the Chinese Delivery Industry’s Workers
The Morality Impact of Price War and Low Salary on the Chinese Delivery Industry’s Workers Open
As is known to all, the delivery industry is one of the world's largest industries nowadays.Moreover, China's delivery is thriving these days, and it has already developed over 30 years with the total number of delivery works achieved more…
View article: TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease
TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease Open
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with cognitive deficits and synaptic impairments. Amyloid-β (Aβ) plaque deposition, dystrophic neurite accumulation and neurofibrillary tangles are pathological…