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View article: An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery
An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery Open
Immune checkpoint blockade (ICB) therapy exerts anti-tumor efficacy mainly by activating intratumoral CD8+ T cells but fails to re-activate terminally exhausted CD8+ T cells. Interleukin-10 (IL-10) has been shown to directly expand and act…
View article: MOFormer: navigating the antimicrobial peptide design space with Pareto-based multi-objective transformer
MOFormer: navigating the antimicrobial peptide design space with Pareto-based multi-objective transformer Open
Antimicrobial peptide (AMP) design through deep learning holds the potential to revolutionize antibiotic development. Despite recent progress in AMP generation, designing peptide antibiotics with multiple optimal properties remains a signi…
View article: Visualization of RIM-BP2’s crane-like function in neuronal vesicle transport using FRET
Visualization of RIM-BP2’s crane-like function in neuronal vesicle transport using FRET Open
"The last mile" of neuronal vesicles, from being tethered by the active zone filaments to docking at the presynaptic membrane, remains unclear, which limits the deep understanding of synaptic transmission and related physiological changes.…
View article: The Role of Hepatic SIRT1: From Metabolic Regulation to Immune Modulation and Multi-target Therapeutic Strategies
The Role of Hepatic SIRT1: From Metabolic Regulation to Immune Modulation and Multi-target Therapeutic Strategies Open
Metabolic dysfunction-associated steatotic liver disease (MASLD), the most common chronic liver disorder worldwide, results from multidimensional network dysregulation involving lipid metabolism imbalance, insulin resistance, oxidative str…
View article: Intraplacental choriocarcinoma and spontaneous fetomaternal hemorrhage: Uncovering diagnostic clues in a challenging case
Intraplacental choriocarcinoma and spontaneous fetomaternal hemorrhage: Uncovering diagnostic clues in a challenging case Open
Background Intraplacental choriocarcinoma (IC) is an extremely rare malignancy of the placenta that is often associated with fetomaternal hemorrhage (FMH). This combination is challenging to diagnose antepartum and is associated with high …
View article: Altered NK Cell Receptor Profiles and Immune-Inflammatory Markers in Adolescent Major Depressive Disorder: Associations with Cognitive Impairment
Altered NK Cell Receptor Profiles and Immune-Inflammatory Markers in Adolescent Major Depressive Disorder: Associations with Cognitive Impairment Open
Background Immune dysregulation and cognitive deficits are increasingly recognized in adolescent major depressive disorder (MDD), yet their interrelationship remains unclear. This study aimed to investigate peripheral immune-inflammatory a…
View article: Inhibitory effects of herbal monomers on ferroptosis in renal fibrosis: a review and mechanistic study
Inhibitory effects of herbal monomers on ferroptosis in renal fibrosis: a review and mechanistic study Open
Background and purpose Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Studies have confirmed the role of ferroptosis in the pathogenesis of various kidney diseases, making it a new research hotspot in the field …
View article: Role of Ferroptosis in Alveolar Epithelial Cells in Acute Respiratory Distress Syndrome
Role of Ferroptosis in Alveolar Epithelial Cells in Acute Respiratory Distress Syndrome Open
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by the rapid onset of respiratory failure resulting from extensive inflammation and damage to the alveolar‒capillary barrier. ARDS can be triggered by…
View article: Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53
Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53 Open
p53 functions as a critical guardian of the genome, orchestrating tumor suppression pathways and ensuring the integrity of chromosomal stability. Mdm2 and MdmX, homologous proteins, serve as negative feedback regulators of p53. In approxim…
View article: The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment
The Role of Ubiquitination on Macrophages in Cardiovascular Diseases and Targeted Treatment Open
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, with macrophage dysfunction playing a central role in its pathogenesis. Ubiquitination, a critical post-translational modification, regulates diverse mac…
View article: Strategies for p53 Activation and Targeted Inhibitors of the p53-Mdm2/MdmX Interaction
Strategies for p53 Activation and Targeted Inhibitors of the p53-Mdm2/MdmX Interaction Open
p53 is a tumor suppressor gene and is regarded as one of the most crucial genes in protecting humans against cancer. The protein Mdm2 and its homolog MdmX serve as negative regulators of p53. In nearly half of cancer cells, there is an ove…
View article: Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake Open
Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in vascular inflammation and atherosclerosis remains unk…
View article: Preoperative multiclass classification of thymic mass lesions based on radiomics and machine learning
Preoperative multiclass classification of thymic mass lesions based on radiomics and machine learning Open
Background Apart from rare cases such as lymphomas, germ cell tumors, neuroendocrine neoplasms, and thymic hyperplasia, thymic mass lesions (TMLs) are typically categorized into cysts, and thymomas. However, the classification results cann…
View article: [Efficacy and safety of PEMD regimen in newly diagnosed early-stage non-upper respiratory digestive tract or advanced extranodal natural killer/T-cell lymphoma].
[Efficacy and safety of PEMD regimen in newly diagnosed early-stage non-upper respiratory digestive tract or advanced extranodal natural killer/T-cell lymphoma]. Open
Objective: To evaluate the efficacy and safety of the pegaspargase, etoposide, methotrexate, and dexamethasone (PEMD) regimen in patients with early-stage nonupper respiratory digestive tract or advanced extranodal natural killer/T-cell ly…
View article: Bromodomain protein 4 inhibitor JQ-1 alleviates hepatic ischemia-reperfusion injury by blocking the NLRP3/caspase-1 pathway
Bromodomain protein 4 inhibitor JQ-1 alleviates hepatic ischemia-reperfusion injury by blocking the NLRP3/caspase-1 pathway Open
JQ-1 has potential as a pre-clinical emergency therapy for hepatic I/R injury. Its ability to inhibit BRD4 and modulate the inflammatory response in Kupffer cells offers a promising avenue for future clinical intervention.
View article: ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction
ET-PROTACs: modeling ternary complex interactions using cross-modal learning and ternary attention for accurate PROTAC-induced degradation prediction Open
Motivation Accurately predicting the degradation capabilities of proteolysis-targeting chimeras (PROTACs) for given target proteins and E3 ligases is important for PROTAC design. The distinctive ternary structure of PROTACs presents a chal…
View article: Role of Hippo/ACSL4 axis in ferroptosis-induced pericyte loss and vascular dysfunction in sepsis
Role of Hippo/ACSL4 axis in ferroptosis-induced pericyte loss and vascular dysfunction in sepsis Open
Sepsis is a critical condition characterized by a systemic inflammatory response to infection, often leading to severe vascular dysfunction and high mortality. One of the hallmarks of vascular dysfunction in sepsis is increased vascular pe…
View article: Advancements in p53-Based Anti-Tumor Gene Therapy Research
Advancements in p53-Based Anti-Tumor Gene Therapy Research Open
The p53 gene is one of the genes most closely associated with human tumors and has become a popular target for tumor drug design. Currently, p53-based gene therapy techniques have been developed, but these therapies face challenges such as…
View article: Novel Targeted Agents in Combination with R-MINE (RMINE+X) Based on Different Molecular Subtypes in Relapsed/Refractory Diffuse Large B-Cell Lymphoma：a Phase 2 Multicenter Study
Novel Targeted Agents in Combination with R-MINE (RMINE+X) Based on Different Molecular Subtypes in Relapsed/Refractory Diffuse Large B-Cell Lymphoma：a Phase 2 Multicenter Study Open
Background The combination of gene-based chemotherapy and targeted therapy in the initial treatment of diffuse large B-cell lymphoma (DLBCL) has shown initial efficacy advantages (Mu-Chen Zhang, Cancer cell), but there have been fewer data…
View article: FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis
FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis Open
FTO suppressed the processing of miR-138-5p and then modulated the proliferation, death, and ferroptosis of gefitinib-resistant cells through the miR-138-5p/LCN2 pathway, which may put forward novel insights for clinically ameliorating the…
View article: MOFormer: Multi-Objective Antimicrobial Peptide Generation through Conditional Transformer with Multi-Fusion Descriptors
MOFormer: Multi-Objective Antimicrobial Peptide Generation through Conditional Transformer with Multi-Fusion Descriptors Open
Deep learning offers considerable potential for designing peptides with desirable properties, essential for expediting drug discovery. Despite recent advances in generating antimicrobial peptides (AMPs), the simultaneous production of AMPs…