Linli Yang
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View article: Atomic structure and in situ visualization of native PMEL lamellae in melanosomes
Atomic structure and in situ visualization of native PMEL lamellae in melanosomes Open
Melanin synthesis within melanosomes critically depends on the fibrillar architecture formed by the pigment cell-specific protein PMEL. Although PMEL fibrils have historically been classified as functional amyloids, their native supramolec…
View article: MSConv-YOLO: An Improved Small Target Detection Algorithm Based on YOLOv8
MSConv-YOLO: An Improved Small Target Detection Algorithm Based on YOLOv8 Open
Small object detection in UAV aerial imagery presents significant challenges due to scale variations, sparse feature representation, and complex backgrounds. To address these issues, this paper focuses on practical engineering improvements…
View article: The efficacy and safety of 5-fluorouracil/cisplatin/vincristine as a multi-agent chemotherapy regimen in gestational trophoblastic neoplasia
The efficacy and safety of 5-fluorouracil/cisplatin/vincristine as a multi-agent chemotherapy regimen in gestational trophoblastic neoplasia Open
Objective To determine the efficacy and safety of the 5-fluorouracil (5-FU), cisplatin, and vincristine (FPV) chemotherapy regimen in patients with gestational trophoblastic neoplasia (GTN). Methods We performed a retrospective study of 96…
View article: Research on Inertial Navigation Technology of Unmanned Aerial Vehicles with Integrated Reinforcement Learning Algorithm
Research on Inertial Navigation Technology of Unmanned Aerial Vehicles with Integrated Reinforcement Learning Algorithm Open
With the continuous expansion of unmanned aerial vehicle (UAV) applications, traditional inertial navigation technology exhibits significant limitations in complex environments. In this study, we integrate improved reinforcement learning (…
View article: Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes
Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes Open
Mammalian centromeres are generally composed of dispersed repeats and the satellites such as α-satellites in human and major/minor satellites in mouse. Transcription of centromeres by RNA polymerase II is evolutionary conserved and critica…
View article: A Nonlinear Adaptive Observer-Based Differential Evolution Algorithm to Multiparameter Fault Diagnosis
A Nonlinear Adaptive Observer-Based Differential Evolution Algorithm to Multiparameter Fault Diagnosis Open
In this paper, a novel adaptive diagnosis scheme is proposed for multiparametric faults of nonlinear systems by using the model and intelligent optimization-based approaches. The key idea of the proposed method is to analyze the correlatio…
View article: Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways Open
Large-conductance and Ca2+-activated K+ (BK) channels are expressed in human hepatic stellate cells (HSCs), where they have roles in normal hepatic microcirculation, as well as in portal hypertension in liver cirrhosis through the regulati…
View article: Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation
Chemotherapy-induced uridine diphosphate release promotes breast cancer metastasis through P2Y6 activation Open
Although purinergic signaling is important in regulation of immune responses, the therapeutic potential of it in the tumor microenvironment is little defined. In this study, we demonstrate that UDP/P2Y6 signaling facilitates breast cancer …