Explanipedia

Ligilactobacillus salivarius alleviated intestinal damage induced by Salmonella in mice via regulating microbiota Open

Xiaohui Liang, Qianqian He, Chang Xu, Munwar Ali, Linlin Gu , et al. · 2025

Collectively, these findings suggest that L. salivarius protects against Salmonella-induced intestinal damage by reducing bacterial load, mitigating intestinal injury, and modulating gut microbiota composition.

Numerical simulation of loess embankment's hydro-thermal dynamics and the stability prediction under climate change Open

Desheng Li, Shengnan Shi, Linlin Gu, Yuye Zhang, Mingli Zhang , et al. · 2025

Rapid and accurate multi-phenotype imputation for millions of individuals Open

Linlin Gu, Hong-Shan Wu, Tianyi Liu, Yongjie Zhang, Jing-Cheng He , et al. · 2025

Ensemble learning for integrative prediction of genetic values with genomic variants Open

Linlin Gu, Runqing Yang, Zhiyong Wang, Dan Jiang, Ming Fang · 2024

Background Whole genome variants offer sufficient information for genetic prediction of human disease risk, and prediction of animal and plant breeding values. Many sophisticated statistical methods have been developed for enhancing the pr…

An Image Fingerprint and Attention Mechanism Based Load Estimation Algorithm for Electric Power System Open

Qing Zhu, Linlin Gu, Huijie Lin · 2024

With the rapid development of electric power systems, load estimation plays an important role in system operation and planning. Usually, load estimation techniques contain traditional, time series, regression analysis-based, and machine le…

Rapid and accurate multi-phenotype imputation for millions of individuals Open

Ming Fang, Linlin Gu, Hong-Shan Wu, Yongjie Zhang, Tianyi Liu , et al. · 2023

Deep phenotyping can enhance the power of genetic analysis such as genome-wide association study (GWAS), but recurrence of missing phenotypes compromises the potentials of such resources. Although many phenotypic imputation methods have be…

A deep learning-based load forecasting algorithm for energy consumption monitoring system using dimension expansion Open

Wei-guo Zhang, Qing Zhu, Linlin Gu, Huijie Lin · 2023

As a basic task in energy consumption monitoring system, load forecasting has great effects on system operation safety, generation costs and economic benefits. In this paper, a long-term load forecasting algorithm using data dimension expa…

Rapid and accurate multi-phenotype imputation for millions of individuals Open

Linlin Gu, Hong-Shan Wu, Tianyi Liu, Yongjie Zhang, Jing-Cheng He , et al. · 2023

Deep phenotyping can enhance the power of genetic analysis, including genome-wide association studies (GWAS), but the occurrence of missing phenotypes compromises the potential of such resources. Although many phenotypic imputation methods…

A hybrid SVR with the firefly algorithm enhanced by a logarithmic spiral for electric load forecasting Open

Weiguo Zhang, Linlin Gu, Shi Yang, Xiaodong Luo, Hu Zhou · 2022

Accurate forecasting of an electric load is vital in the effective management of a power system, especially in flourishing regions. A new hybrid model called logarithmic spiral firefly algorithm-support vector regression (LS-FA-SVR) is pro…

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling Open

Linlin Gu, Ranu Surolia, Jennifer L. Larson‐Casey, Chao He, Dana Davis , et al. · 2021

Post‐translational regulation of PGC‐1α modulates fibrotic repair Open

Jennifer L. Larson‐Casey, Linlin Gu, Dana Davis, Guoqiang Cai, Qiang Ding , et al. · 2021

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease associated with mitochondrial oxidative stress. Mitochondrial reactive oxygen species (mtROS) are important for cell homeostasis by regulating mitochondrial dynamics. Here, …

NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression Open

Jennifer L. Larson‐Casey, Linlin Gu, Jungsoon Kang, A. Dhyani, A. Brent Carter · 2021

Evaluation for the effect of low-coverage sequencing on genomic selection in large yellow croaker Open

Wenjing Zhang, Wanbo Li, Guijia Liu, Linlin Gu, Kun Ye , et al. · 2020

Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages Open

Jennifer L. Larson‐Casey, Linlin Gu, Oliver Fiehn, A. Brent Carter · 2020

Heavy metals released into the environment have a significant effect on respiratory health. Lung macrophages are important in mounting an inflammatory response to injury, but they are also involved in repair of injury. Macrophages develop …

Evaluation of Genomic Selection for Seven Economic Traits in Yellow Drum (Nibea albiflora) Open

Guijia Liu, Linsong Dong, Linlin Gu, Zhaofang Han, Wenjing Zhang , et al. · 2019

Increased flux through the mevalonate pathway mediates fibrotic repair without injury Open

Jennifer L. Larson‐Casey, Mudit Vaid, Linlin Gu, Chao He, Guo-Qiang Cai , et al. · 2019

Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be increased in fibrotic models; however, the role of these proteins in idiopathic pulmon…

Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis Open

Linlin Gu, Jennifer L. Larson‐Casey, Shaida A. Andrabi, Jun Hee Lee, Selene Meza‐Perez , et al. · 2019

NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis Open

Chao He, Jennifer L. Larson‐Casey, Dana Davis, Vidya Sagar Hanumanthu, Ana Leda F. Longhini , et al. · 2019

Macrophage activation is implicated in the development of pulmonary fibrosis by generation of profibrotic molecules. Although NADPH oxidase 4 (NOX4) is known to contribute to pulmonary fibrosis, its effects on macrophage activation and mit…

Exosome Biogenesis and Biological Function in Response to Viral Infections Open

Brennetta J. Crenshaw, Linlin Gu, Brian Sims, Qiana L. Matthews · 2018

Introduction: Exosomes are extracellular vesicles that originate as intraluminal vesicles during the process of multivescular body formation. Exosomes mediate intercellular transfer of functional proteins, lipids, and RNAs. The investigati…

Pathogens and Their Effect on Exosome Biogenesis and Composition Open

Leandra B. Jones, Courtnee’ R. Bell, Kartz E. Bibb, Linlin Gu, Mamie T. Coats , et al. · 2018

Exosomes are nanosized membrane microvesicles (30–100 nm) that have the capability to communicate intercellularly and transport cell components (i.e., miRNA, mRNA, proteins and DNA). Exosomes are found in nearly every cell type (i.e., mast…

Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke–induced Pneumonia Open

Jennifer L. Larson‐Casey, Linlin Gu, Patricia L. Jackson, David E. Briles, Joanetha Y. Hale , et al. · 2018

These observations suggest that therapies to maintain Rac2 activity in lung macrophages restore host defense against respiratory pathogens and diminish the prevalence of LRTIs in subjects that smoke.

H7N9 virulent mutants detected in chickens in China pose an increased threat to humans Open

Jianzhong Shi, Guohua Deng, Huihui Kong, Chunyang Gu, Shujie Ma , et al. · 2017

Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus Open

Yong Ma, Jiashan Sun, Linlin Gu, Hongmei Bao, Yuhui Zhao , et al. · 2017

Our results indicate that ANXA2 interacts with NS1 and ANXA2 expression increases HPAIV replication.

Development of a real-time RT-PCR method for the detection of newly emerged highly pathogenic H7N9 influenza viruses Open

Xiurong Wang, Linlin Gu, Jianzhong Shi, Haifeng Xu, Ying Zhang , et al. · 2017

In 2013, a human influenza outbreak caused by a novel H7N9 virus occurred in China. Recently, the H7N9 virus acquired multiple basic amino acids at its hemagglutinin (HA) cleavage site, leading to the emergence of a highly pathogenic virus…

Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells Open

Brian Sims, Anitra L. Farrow, Sparkle D. Williams, Anju Bansal, Alexandre Krendelchtchikov , et al. · 2017

Exosomes, 30-200 nm nanostructures secreted from donor cells and internalized by recipient cells, can play an important role in the cellular entry of some viruses. These microvesicles are actively secreted into various body fluids, includi…

Differential binding of the HIV-1 envelope to phosphatidylserine receptors Open

Linlin Gu, Brian Sims, Alexandre Krendelchtchikov, Edlue M. Tabengwa, Qiana L. Matthews · 2017

Prior work has shown that the HIV-1 envelope of the human immunodeficiency virus (HIV) interacts directly with T-cell immunoglobulin mucin (TIM) family proteins. Herein, we demonstrate that HIV-1 envelope glycoproteins from varying HIV-1 c…

Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization Open

Linlin Gu, Jennifer L. Larson‐Casey, A. Brent Carter · 2017

Fibrosis in multiple organs, including the liver, kidney, and lung, often occurs secondary to environmental exposure. Asbestos exposure is one important environmental cause of lung fibrosis. The mechanisms that mediate fibrosis is not full…

Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease Open

Qiana L. Matthews, Anitra L. Farrow, Girish Rachakonda, Linlin Gu, Pius N. Nde , et al. · 2016

Background: Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi (T. cruzi) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infectio…

Development of an Ad5H3 Chimera Using the “Antigen Capsid-Incorporation” Strategy for an Alternative Vaccination Approach Open

Linlin Gu, Mert Icyuz, Valentina Krendelchtchikova, Alexandre Krendelchtchikov, Alison E. Johnston , et al. · 2016

Background: Adenovirus type 5 (Ad5) achieved success as a conventional transgene vaccine vector in preclinical trials, however; achieved poor efficiency in some of the clinical trials, due to the major hurdle associated with Ad5 pre-existi…

A Novel Vaccine Approach for Chagas Disease Using Rare Adenovirus Serotype 48 Vectors Open

Anitra L. Farrow, Binghao J. Peng, Linlin Gu, Alexandre Krendelchtchikov, Qiana L. Matthews · 2016

Due to the increasing amount of people afflicted worldwide with Chagas disease and an increasing prevalence in the United States, there is a greater need to develop a safe and effective vaccine for this neglected disease. Adenovirus seroty…

Linlin Gu YOU? Author Swipe